In:
Neuropathology, Wiley, Vol. 38, No. 3 ( 2018-06), p. 281-287
Abstract:
Catatonia is a clinical syndrome characterized by symptoms such as immobility, mutism, stupor, stereotypy, echophenomena, catalepsy, automatic obedience, posturing, negativism, gegenhalten and ambitendency. This syndrome occurs mostly in mood disorder and schizophrenic patients, and is related to neuronal dysfunction involving the frontal lobe. Some cases of frontotemporal dementia (FTD) with catatonia have been reported, but these cases were not examined by autopsy. Here, we report on a FTD case which showed catatonia after the first episode of brief psychotic disorder. At the age of 58, the patient had a sudden onset of disorganized behavior and meaningless speech. Psychotropic drugs were effective for catatonic symptoms. However, after remission apathy, hyperorality, socially inappropriate behavior, hoarding, and an instinctive grasp reaction appeared and persisted. Brain MRI showed significant atrophy of the bilateral fronto‐temporal lobes. A neuropathological examination revealed extensive trans‐activation response DNA‐binding protein 43 (TDP‐43) positive neurocytoplasmic inclusions and dystrophic neurites in the brain, including the cerebral cortex, basal ganglia, and brainstem. Pathological diagnosis was frontotemporal lobar degeneration (FTLD) with TDP‐43 (FTLD‐TDP) type C, which was also confirmed by the band pattern of C‐terminal fragments of TDP‐43 on western blotting of sarkosyl‐insoluble fractions extracted from the frozen brain. Dysfunction of the thalamus, globus pallidus, supplementary motor area, amygdala and cingulate cortex have been said to be related to the catatonic syndrome. In this case, these areas were affected, showing abnormal TDP‐43‐positive structures. Further studies are expected to confirm further clinical ‐ pathological correlations to FTLD.
Type of Medium:
Online Resource
ISSN:
0919-6544
,
1440-1789
DOI:
10.1111/neup.2018.38.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2008290-3
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