Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Wiley ; 2010
    In:  Integrated Environmental Assessment and Management Vol. 6, No. 2 ( 2010-04), p. 210-224
    In: Integrated Environmental Assessment and Management, Wiley, Vol. 6, No. 2 ( 2010-04), p. 210-224
    Abstract: It has been asserted that, when screening chemicals for bioaccumulation potential, molecular size cutoff criteria (or indicators) can be applied above which no, or limited, bioaccumulation is expected. The suggested molecular size values have increased over time as more measurements have become available. Most of the proposed criteria have been derived from unevaluated fish bioconcentration factor (BCF) data, and less than 5% of existing organic substances have measured BCFs. We critically review the proposed criteria, first by considering other factors that may also contribute to reduced bioaccumulation for larger molecules, namely, reduced bioavailability in the water column, reduced rate of uptake corresponding to reduced diffusion rates, and the effects of biotransformation and growth dilution. An evaluated BCF and bioaccumulation factor (BAF) database for more than 700 substances and dietary uptake efficiency data are compared against proposed cutoff values. We examine errors associated with interpreting BCF data, particularly for developing molecular size criteria of bioaccumulation potential. Reduced bioaccumulation that is often associated with larger molecular size can be explained by factors other than molecular size, and there is evidence of absorption of molecules exceeding the proposed cutoff criteria. The available data do not support strict cutoff criteria, indicating that the proposed values are incorrect. Rather than assessing bioaccumulation using specific chemical properties in isolation, holistic methods that account for competing rates of uptake and elimination in an organism are recommended. An integrated testing strategy is suggested to improve knowledge of the absorption and bioaccumulation of large substances. Integr Environ Assess Manag 2010;6:210–224. © 2009 SETAC
    Type of Medium: Online Resource
    ISSN: 1551-3777 , 1551-3793
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2231760-0
    SSG: 21
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    American Chemical Society (ACS) ; 2011
    In:  Environmental Science & Technology Vol. 45, No. 1 ( 2011-01-01), p. 97-103
    In: Environmental Science & Technology, American Chemical Society (ACS), Vol. 45, No. 1 ( 2011-01-01), p. 97-103
    Type of Medium: Online Resource
    ISSN: 0013-936X , 1520-5851
    RVK:
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2011
    detail.hit.zdb_id: 280653-8
    detail.hit.zdb_id: 1465132-4
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: Science of The Total Environment, Elsevier BV, Vol. 458-460 ( 2013-08), p. 555-567
    Type of Medium: Online Resource
    ISSN: 0048-9697
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 1498726-0
    detail.hit.zdb_id: 121506-1
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Online Resource
    Online Resource
    Elsevier BV ; 2019
    In:  Environment International Vol. 122 ( 2019-01), p. 117-129
    In: Environment International, Elsevier BV, Vol. 122 ( 2019-01), p. 117-129
    Type of Medium: Online Resource
    ISSN: 0160-4120
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 554791-X
    detail.hit.zdb_id: 1497569-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Online Resource
    Online Resource
    Canadian Science Publishing ; 2006
    In:  Environmental Reviews Vol. 14, No. 4 ( 2006-12-01), p. 257-297
    In: Environmental Reviews, Canadian Science Publishing, Vol. 14, No. 4 ( 2006-12-01), p. 257-297
    Abstract: Bioaccumulation assessment is important in the scientific evaluation of risks that chemicals may pose to humans and the environment and is a current focus of regulatory effort. The status of bioaccumulation evaluations for organic chemicals in aquatic systems is reviewed to reduce uncertainty in bioaccumulation measurement, to provide quality data for assessment, and to assist in model development. A review of 392 scientific literature and database sources includes 5317 bioconcentration factor (BCF) and 1656 bioaccumulation factor (BAF) values measured for 842 organic chemicals in 219 aquatic species. A data quality assessment finds that 45% of BCF values are subject to at least one major source of uncertainty and that measurement errors generally result in an underestimation of actual BCF values. A case study of organic chemicals on the Canadian Domestic Substances List indicates that empirical data are available for less than 4% of the chemicals that require evaluation and of these chemicals, 76% have less than three acceptable quality BCF or BAF values. Field BAFs tend to be greater than laboratory BCFs emphasizing the importance of environmental measurement for reliable assessment; however, only 0.2% of current use organic chemicals have BAF measurements. Key parameters influencing uncertainty and variability in BCF and BAF data are discussed using reviewed data and models. A critical evaluation of representative BCF and BAF models in relation to existing measurements and regulatory criteria in Canada indicate the probability of Type II errors, i.e., false negatives or ``misses'', using BCF models for bioaccumulation assessment may be as high as 70.6% depending on the model. Recommendations for the selection of measured and modelled values used in bioaccumulation assessment are provided, and improvements for the science and regulatory criteria are proposed.Key words: bioconcentration, bioconcentration factor, bioaccumulation, bioaccumulation factor, octanol–water partition coefficient, fish.
    Type of Medium: Online Resource
    ISSN: 1181-8700 , 1208-6053
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 2006
    detail.hit.zdb_id: 2027518-3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Online Resource
    Online Resource
    Wiley ; 2021
    In:  Environmental Toxicology and Chemistry Vol. 40, No. 11 ( 2021-11), p. 3123-3136
    In: Environmental Toxicology and Chemistry, Wiley, Vol. 40, No. 11 ( 2021-11), p. 3123-3136
    Abstract: Biotransformation may substantially reduce the extent to which organic environmental contaminants accumulate in fish. Presently, however, relatively little is known regarding the biotransformation of ionized chemicals, including cationic surfactants, in aquatic organisms. To address this deficiency, a rainbow trout liver S9 substrate depletion assay (RT‐S9) was used to measure in vitro intrinsic clearance rates (CL int ; ml min –1 g liver –1 ) for 22 cationic surfactants that differ with respect to alkyl chain length and degree of methylation on the charged nitrogen atom. None of the quaternary N,N,N ‐trimethylalkylammonium compounds exhibited significant clearance. Rapid clearance was observed for N,N ‐dimethylalkylamines, and slower rates of clearance were measured for N ‐methylalkylamine analogs. Clearance rates for primary alkylamines were generally close to or below detectable levels. For the N ‐methylalkylamines and N,N ‐dimethylalkylamines, the highest CL int values were measured for C 10 –C 12 homologs; substantially lower clearance rates were observed for homologs containing shorter or longer carbon chains. Based on its cofactor dependency, biotransformation of C 12 – N,N‐ dimethylamine appears to involve one or more cytochrome P450–dependent reaction pathways, and sulfonation. On a molar basis, N‐ demethylation metabolites accounted for up to 25% of the N,N ‐dimethylalkylamines removed during the 2‐h assay, and up to 55% of the removed N ‐methylalkylamines. These N ‐demethylation products possess greater metabolic stability in the RT‐S9 assay than the parent structures from which they derive and may contribute to the overall risk of ionizable alkylamines. The results of these studies provide a set of consistently determined CL int values that may be extrapolated to whole trout to inform in silico bioaccumulation assessments. Environ Toxicol Chem 2021;40:3123–3136. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
    Type of Medium: Online Resource
    ISSN: 0730-7268 , 1552-8618
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2027441-5
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Online Resource
    Online Resource
    Wiley ; 2021
    In:  Environmental Toxicology and Chemistry Vol. 40, No. 4 ( 2021-04), p. 1204-1211
    In: Environmental Toxicology and Chemistry, Wiley, Vol. 40, No. 4 ( 2021-04), p. 1204-1211
    Abstract: Following a recent proposal of normalizing the experimentally derived biomagnification factor (BMF) to a 5% lipid content in fish, we explore the normalization of the BMF of lipophilic chemicals in fish. We illustrate with theoretical models and experimental data that the BMF of lipophilic chemicals is a function of the lipid content of the diet and that poorly metabolizable, lipophilic chemicals biomagnify in organisms to a greater degree when present in higher–lipid content food. The proposed normalization of the laboratory BMF to the lipid content of the fish and subsequent standardization to a 5% fish lipid content, which is numerically identical to normalizing the BMF to a 5% dietary lipid content, has the potential to underestimate the biomagnification potential of lipophilic substances in aquatic food webs. The BMF normalized to both the lipid content of the fish and the lipid content of the diet, which is the biomagnification metric included in the Organisation for Economic Co‐operation and Development's bioaccumulation testing guideline 305, better represents real‐world biomagnification than the proposed BMF normalized and standardized to a 5% lipid content in fish. Environ Toxicol Chem 2021;40:1204–1211. © 2020 SETAC
    Type of Medium: Online Resource
    ISSN: 0730-7268 , 1552-8618
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2027441-5
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Online Resource
    Online Resource
    Wiley ; 2016
    In:  Environmental Toxicology and Chemistry Vol. 35, No. 5 ( 2016-05), p. 1257-1267
    In: Environmental Toxicology and Chemistry, Wiley, Vol. 35, No. 5 ( 2016-05), p. 1257-1267
    Abstract: A novel dynamic fugacity‐based model is described, developed, and tested that simulates the uptake of narcotic organic chemicals in fish from water as occurs in aquatic bioconcentration and toxicity tests. The physiologically based toxicokinetic model treats the time course of chemical distribution in 4 compartments (tissue groups) in the fish, including the liver, in which biotransformation may occur. In addition to calculating bioconcentration and toxicokinetics, 5 possible toxic endpoints are defined corresponding to chemical concentration, fugacity, or activity reaching a critical value that causes 50% mortality. The mathematical description of multicompartment uptake is simplified by expressing the equations in the fugacity format. The model is parameterized and tested against reported empirical data for the bioconcentration of pentachloroethane in rainbow trout and for uptake and mortality from aquatic exposures to naphthalene and 1,2,4‐trichlorobenzene in fathead minnows. Model performance is evaluated, and it is concluded that with suitable parameterization it has potential for application for assessment of both bioconcentration and toxicity expressed as median lethal concentrations, critical body residues, and chemical activity as a function of time to death. Environ Toxicol Chem 2016;35:1257–1267. © 2015 SETAC
    Type of Medium: Online Resource
    ISSN: 0730-7268 , 1552-8618
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2027441-5
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    In: Environmental Toxicology and Chemistry, Wiley, Vol. 36, No. 4 ( 2017-04), p. 882-897
    Abstract: The objective of the present study was to review the current knowledge regarding the bioaccumulation potential of ionizable organic compounds (IOCs), with a focus on the availability of empirical data for fish. Aspects of the bioaccumulation potential of IOCs in fish that can be characterized relatively well include the pH dependence of gill uptake and elimination, uptake in the gut, and sorption to phospholipids (membrane–water partitioning). Key challenges include the lack of empirical data for biotransformation and binding in plasma. Fish possess a diverse array of proteins that may transport IOCs across cell membranes. Except in a few cases, however, the significance of this transport for uptake and accumulation of environmental contaminants is unknown. Two case studies are presented. The first describes modeled effects of pH and biotransformation on the bioconcentration of organic acids and bases, while the second employs an updated model to investigate factors responsible for accumulation of perfluorinated alkyl acids. The perfluorinated alkyl acid case study is notable insofar as it illustrates the likely importance of membrane transporters in the kidney and highlights the potential value of read‐across approaches. Recognizing the current need to perform bioaccumulation hazard assessments and ecological and exposure risk assessment for IOCs, the authors provide a tiered strategy that progresses (as needed) from conservative assumptions (models and associated data) to more sophisticated models requiring chemical‐specific information. Environ Toxicol Chem 2017;36:882–897. © 2016 SETAC
    Type of Medium: Online Resource
    ISSN: 0730-7268 , 1552-8618
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2027441-5
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Online Resource
    Online Resource
    Wiley ; 2012
    In:  Environmental Toxicology and Chemistry Vol. 31, No. 10 ( 2012-10), p. 2261-2268
    In: Environmental Toxicology and Chemistry, Wiley, Vol. 31, No. 10 ( 2012-10), p. 2261-2268
    Abstract: The fish bioconcentration factor (BCF), as calculated from controlled laboratory tests, is commonly used in chemical management programs to screen chemicals for bioaccumulation potential. The bioaccumulation factor (BAF), as calculated from field‐caught fish, is more ecologically relevant because it accounts for dietary, respiratory, and dermal exposures. The BCFBAF™ program in the U.S. Environmental Protection Agency's Estimation Programs Interface Suite (EPI Suite™ Ver 4.10) screening‐level tool includes the Arnot‐Gobas quantitative structure–activity relationship model to estimate BAFs for organic chemicals in fish. Bioaccumulation factors can be greater than BCFs, suggesting that using the BAF rather than the BCF for screening bioaccumulation potential could have regulatory and resource implications for chemical assessment programs. To evaluate these potential implications, BCFBAF was used to calculate BAFs and BCFs for 6,034 U.S. high‐ and medium‐production volume chemicals. The results indicate no change in the bioaccumulation rating for 86% of these chemicals, with 3% receiving lower and 11% receiving higher bioaccumulation ratings when using the BAF rather than the BCF. All chemicals that received higher bioaccumulation ratings had log K OW values greater than 4.02, in which a chemical's BAF was more representative of field‐based bioaccumulation than its BCF. Similar results were obtained for 374 new chemicals. Screening based on BAFs provides ecologically relevant results without a substantial increase in resources needed for assessments or the number of chemicals screened as being of concern for bioaccumulation potential. Environ. Toxicol. Chem. 2012; 31: 2261–2268. © 2012 SETAC
    Type of Medium: Online Resource
    ISSN: 0730-7268 , 1552-8618
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2027441-5
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages