KOBV Portal

Hits per page

hits 1 - 10 | 26 hits

Sorting

Online Resource

TheNotch locus of Drosophila melanogaster: A molecular analysis

Artavanis-Tsakonas, Spyros ; Grimwade, Brian G. ; Harrison, Richard G. ; [et al.]

Wiley ; 1983

In: Developmental Genetics Vol. 4, No. 4 ( 1983), p. 233-254

add to watchlist on the watchlist

Details

In: Developmental Genetics, Wiley, Vol. 4, No. 4 ( 1983), p. 233-254

Type of Medium: Online Resource

ISSN: 0192-253X , 1520-6408

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/dvg.v4:4

DOI: 10.1002/(ISSN)1520-6408

DOI: 10.1002/dvg.1020040403

RVK:

WG 4000

Language: English

Publisher: Wiley

Publication Date: 1983

detail.hit.zdb_id: 1500240-8

detail.hit.zdb_id: 2019664-7

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum

Artavanis‐Tsakonas, Katerina ; Misaghi, Shahram ; Comeaux, Christy A. ; [et al.]

Wiley ; 2006

In: Molecular Microbiology Vol. 61, No. 5 ( 2006-09), p. 1187-1195

add to watchlist on the watchlist

Details

In: Molecular Microbiology, Wiley, Vol. 61, No. 5 ( 2006-09), p. 1187-1195

Abstract: Ubiquitination is a post‐translational modification implicated in a variety of cellular functions, including transcriptional regulation, protein degradation and membrane protein trafficking. Ubiquitin and the enzymes that act on it, although conserved and essential in eukaryotes, have not been well studied in parasites, despite sequencing of several parasite genomes. Several putative ubiquitin hydrolases have been identified in Plasmodium falciparum based on sequence homology alone, with no evidence of expression or function. Here we identify the first deubiquitinating enzyme in P. falciparum , PfUCH54, by its activity. We show that PfUCH54 also has deNeddylating activity, as assayed by a mammalian Nedd8‐based probe. This activity is absent from mammalian homologues of PfUCH54. Given the importance of parasitic membrane protein trafficking as well as protein degradation in the virulence of this parasite, this family of enzymes may represent a target for pharmacological intervention with this disease.

Type of Medium: Online Resource

ISSN: 0950-382X , 1365-2958

URL: Issue

URL: Article

DOI: 10.1111/mmi.2006.61.issue-5

DOI: 10.1111/j.1365-2958.2006.05307.x

Language: English

Publisher: Wiley

Publication Date: 2006

detail.hit.zdb_id: 1501537-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification

Artavanis-Tsakonas, Katerina ; Love, J. Christopher ; Ploegh, Hidde L. ; [et al.]

Proceedings of the National Academy of Sciences ; 2006

In: Proceedings of the National Academy of Sciences Vol. 103, No. 43 ( 2006-10-24), p. 15945-15950

add to watchlist on the watchlist

Details

In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 103, No. 43 ( 2006-10-24), p. 15945-15950

Abstract: The subcellular localization of the cluster of differentiation 63 (CD63) tetraspanin and its interaction with the class II MHC antigen presentation pathway were examined in the context of phagocytosis by live cell imaging, by using monomeric red fluorescent protein-tagged mouse CD63 expressed in primary bone marrow-derived cell cultures. Upon phagocytosis of Cryptococcus neoformans and polystyrene beads, CD63 was recruited selectively to C. neoformans -containing phagosomes in a MyD88-independent acidification-dependent manner. Bead-containing phagosomes, within a C. neoformans -containing cell, acidified to a lesser extent and failed to recruit CD63 to a level detectable by microscopy. CD63 recruitment to yeast phagosomes occurred independently of class II MHC and LAMP-1. These observations indicate that the composition of distinct phagosomal compartments within the same cell is determined by phagosomal cargo and may affect the outcome of antigen processing and presentation.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.0607528103

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 2006

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Notch and the molecular genetics of neuroblast segregation inDrosophila

Artavanis-Tsakonas, Spyros ; Delidakis, Christos ; Fehon, Rick ; [et al.]

Wiley ; 1990

In: Molecular Reproduction and Development Vol. 27, No. 1 ( 1990-09), p. 23-27

add to watchlist on the watchlist

Details

In: Molecular Reproduction and Development, Wiley, Vol. 27, No. 1 ( 1990-09), p. 23-27

Type of Medium: Online Resource

ISSN: 1040-452X , 1098-2795

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/mrd.v27:1

DOI: 10.1002/(ISSN)1098-2795

DOI: 10.1002/mrd.1080270107

Language: English

Publisher: Wiley

Publication Date: 1990

detail.hit.zdb_id: 1493888-1

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

How helminths use excretory secretory fractions to modulate dendritic cells

White, Rhiannon R. ; Artavanis-Tsakonas, Katerina

Informa UK Limited ; 2012

In: Virulence Vol. 3, No. 7 ( 2012-11-15), p. 668-677

add to watchlist on the watchlist

Details

In: Virulence, Informa UK Limited, Vol. 3, No. 7 ( 2012-11-15), p. 668-677

Type of Medium: Online Resource

ISSN: 2150-5594 , 2150-5608

URL: Article

DOI: 10.4161/viru.22832

Language: English

Publisher: Informa UK Limited

Publication Date: 2012

detail.hit.zdb_id: 2657572-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

CD82 controls CpG‐dependent TLR9 signaling

Khan, Nida S. ; Lukason, Daniel P. ; Feliu, Marianela ; [et al.]

Wiley ; 2019

In: The FASEB Journal Vol. 33, No. 11 ( 2019-11), p. 12500-12514

add to watchlist on the watchlist

Details

In: The FASEB Journal, Wiley, Vol. 33, No. 11 ( 2019-11), p. 12500-12514

Type of Medium: Online Resource

ISSN: 0892-6638 , 1530-6860

URL: Issue

URL: Article

DOI: 10.1096/fsb2.v33.11

DOI: 10.1096/fj.201901547R

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 1468876-1

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection

Temporão, Adriana ; Sanches-Vaz, Margarida ; Luís, Rafael ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Neglected Tropical Diseases Vol. 15, No. 10 ( 2021-10-29), p. e0009912-

add to watchlist on the watchlist

Details

In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 10 ( 2021-10-29), p. e0009912-

Abstract: Malaria, a disease caused by Plasmodium parasites, remains a major threat to public health globally. It is the most common disease in patients with sleeping sickness, another parasitic illness, caused by Trypanosoma brucei . We have previously shown that a T . brucei infection impairs a secondary P . berghei liver infection and decreases malaria severity in mice. However, whether this effect requires an active trypanosome infection remained unknown. Here, we show that Plasmodium liver infection can also be inhibited by the serum of a mouse previously infected by T . brucei and by total protein lysates of this kinetoplastid. Biochemical characterisation showed that the anti- Plasmodium activity of the total T . brucei lysates depends on its protein fraction, but is independent of the abundant variant surface glycoprotein. Finally, we found that the protein(s) responsible for the inhibition of Plasmodium infection is/are present within a fraction of ~350 proteins that are excreted to the bloodstream of the host. We conclude that the defence mechanism developed by trypanosomes against Plasmodium relies on protein excretion. This study opens the door to the identification of novel antiplasmodial intervention strategies.

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0009912

DOI: 10.1371/journal.pntd.0009912.g001

DOI: 10.1371/journal.pntd.0009912.g002

DOI: 10.1371/journal.pntd.0009912.g003

DOI: 10.1371/journal.pntd.0009912.g004

DOI: 10.1371/journal.pntd.0009912.g005

DOI: 10.1371/journal.pntd.0009912.t001

DOI: 10.1371/journal.pntd.0009912.s001

DOI: 10.1371/journal.pntd.0009912.s002

DOI: 10.1371/journal.pntd.0009912.s003

DOI: 10.1371/journal.pntd.0009912.s004

DOI: 10.1371/journal.pntd.0009912.s005

DOI: 10.1371/journal.pntd.0009912.s006

DOI: 10.1371/journal.pntd.0009912.s007

DOI: 10.1371/journal.pntd.0009912.s008

DOI: 10.1371/journal.pntd.0009912.s009

DOI: 10.1371/journal.pntd.0009912.r001

DOI: 10.1371/journal.pntd.0009912.r002

DOI: 10.1371/journal.pntd.0009912.r003

DOI: 10.1371/journal.pntd.0009912.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2429704-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Developmental analysis of thefacets, a group of intronic mutations at theNotch locus ofDrosophila melanogaster that affect postembryonic development

Markopoulou, Katerina ; Artavanis-Tsakonas, Spyros

Wiley ; 1991

In: Journal of Experimental Zoology Vol. 257, No. 3 ( 1991-03), p. 314-329

add to watchlist on the watchlist

Details

In: Journal of Experimental Zoology, Wiley, Vol. 257, No. 3 ( 1991-03), p. 314-329

Type of Medium: Online Resource

ISSN: 0022-104X , 1097-010X

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/jez.v257:3

DOI: 10.1002/(ISSN)1097-010X

DOI: 10.1002/jez.1402570305

Language: English

Publisher: Wiley

Publication Date: 1991

detail.hit.zdb_id: 2205981-7

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

Klinakis, Apostolos ; Szabolcs, Matthias ; Politi, Katerina ; [et al.]

Proceedings of the National Academy of Sciences ; 2006

In: Proceedings of the National Academy of Sciences Vol. 103, No. 24 ( 2006-06-13), p. 9262-9267

add to watchlist on the watchlist

Details

In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 103, No. 24 ( 2006-06-13), p. 9262-9267

Abstract: To explore the potential involvement of aberrant Notch1 signaling in breast cancer pathogenesis, we have used a transgenic mouse model. In these animals, mouse mammary tumor virus LTR-driven expression of the constitutively active intracellular domain of the Notch1 receptor (N1 IC ) causes development of lactation-dependent mammary tumors that regress upon gland involution but progress to nonregressing, invasive adenocarcinomas in subsequent pregnancies. Up-regulation of Myc in these tumors prompted a genetic investigation of a potential Notch1/Myc functional relationship in breast carcinogenesis. Conditional ablation of Myc in the mammary epithelium prevented the induction of regressing N1 IC neoplasms and also reduced the incidence of nonregressing carcinomas, which developed with significantly increased latency. Molecular analyses revealed that both the mouse and human Myc genes are direct transcriptional targets of N1 IC acting through its downstream Cbf1 transcriptional effector. Consistent with this mechanistic link, Notch1 and Myc expression is positively correlated by immunostaining in 38% of examined human breast carcinomas.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.0603371103

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 2006

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Uninfected erythrocytes inhibit Plasmodium falciparum–induced cellular immune responses in whole-blood assays

Struik, Siske S. ; Omer, Fakhreldin M. ; Artavanis-Tsakonas, Katerina ; [et al.]

American Society of Hematology ; 2004

In: Blood Vol. 103, No. 8 ( 2004-04-15), p. 3084-3092

add to watchlist on the watchlist

Details

In: Blood, American Society of Hematology, Vol. 103, No. 8 ( 2004-04-15), p. 3084-3092

Abstract: Whole-blood assays (WBAs) have been successfully used as a simple tool for immuno-epidemiological field studies evaluating cellular immune responses to mycobacterial and viral antigens. Rather unexpectedly, we found very poor cytokine responses to malaria antigens in WBAs in 2 immuno-epidemiological studies carried out in malaria endemic populations in Africa. We have therefore conducted a detailed comparison of cellular immune responses to live (intact) and lysed malaria-infected erythrocytes in WBAs and in peripheral blood mononuclear cell (PBMC) cultures. We observed profound inhibition of both proliferative and interferon-γ responses to malarial antigens in WBAs as compared with PBMC cultures. This inhibition was seen only for malaria antigens and could not be overcome by increasing either antigen concentration or responder cell numbers. Inhibition was mediated by intact erythrocytes and occurred early in the culture period, suggesting that failure of antigen uptake might underlie the lack of T-cell responses. In support of this hypothesis, we have shown that intact uninfected erythrocytes specifically inhibit phagocytosis of infected red blood cells by peripheral blood monocytes. We propose that specific biochemical interactions with uninfected erythrocytes inhibit the phagocytosis of malaria-infected erythrocytes and that this may impede T-cell recognition in vivo. (Blood. 2004; 103:3084-3092)

Type of Medium: Online Resource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood-2003-08-2867

RVK:

XA 33000

RVK:

XA 10000

Language: English

Publisher: American Society of Hematology

Publication Date: 2004

detail.hit.zdb_id: 1468538-3

detail.hit.zdb_id: 80069-7

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 26 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg