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Novel syntheses of 3-anilino-pyrazin-2(1H)-ones and 3-anilino-quinoxalin-2-(1H)-ones via microwave-mediated Smiles rearrangement

Christopher Bi, F. ; Aspnes, Gary E. ; Guzman-Perez, Angel ; [et al.]

Elsevier BV ; 2008

In: Tetrahedron Letters Vol. 49, No. 11 ( 2008-3), p. 1832-1835

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In: Tetrahedron Letters, Elsevier BV, Vol. 49, No. 11 ( 2008-3), p. 1832-1835

Type of Medium: Online Resource

ISSN: 0040-4039

URL: Article

DOI: 10.1016/j.tetlet.2008.01.056

RVK:

VA 7560

Language: English

Publisher: Elsevier BV

Publication Date: 2008

detail.hit.zdb_id: 2007074-3

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Identification of a novel conformationally constrained glucagon receptor antagonist

Lee, Esther C.Y. ; Tu, Meihua ; Stevens, Benjamin D. ; [et al.]

Elsevier BV ; 2014

In: Bioorganic & Medicinal Chemistry Letters Vol. 24, No. 3 ( 2014-02), p. 839-844

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 24, No. 3 ( 2014-02), p. 839-844

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2013.12.090

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core

Dow, Robert L. ; Andrews, Melissa ; Aspnes, Gary E. ; [et al.]

Elsevier BV ; 2011

In: Bioorganic & Medicinal Chemistry Letters Vol. 21, No. 20 ( 2011-10), p. 6122-6125

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 21, No. 20 ( 2011-10), p. 6122-6125

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2011.08.028

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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Efficient Synthesis of 4-Amino-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5-ones: Practical Access to a Novel Chemotype in the Development of DGAT-1 Inhibitors

Bahnck, Kevin ; Tao, Yong ; Shavnya, Andrei ; [et al.]

Georg Thieme Verlag KG ; 2012

In: Synthesis Vol. 44, No. 20 ( 2012-7-3), p. 3152-3157

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In: Synthesis, Georg Thieme Verlag KG, Vol. 44, No. 20 ( 2012-7-3), p. 3152-3157

Type of Medium: Online Resource

ISSN: 0039-7881 , 1437-210X

URL: Issue

URL: Journal

URL: Article

DOI: 10.1055/s-002-23872

DOI: 10.1055/s-00000084

DOI: 10.1055/s-0032-1316756

RVK:

VA 7380

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2012

detail.hit.zdb_id: 204080-3

detail.hit.zdb_id: 2033062-5

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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents

Londregan, Allyn T. ; Wei, Liuqing ; Xiao, Jun ; [et al.]

American Chemical Society (ACS) ; 2018

In: Journal of Medicinal Chemistry Vol. 61, No. 13 ( 2018-07-12), p. 5704-5718

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 61, No. 13 ( 2018-07-12), p. 5704-5718

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/acs.jmedchem.8b00650

DOI: 10.1021/acs.jmedchem.8b00650.s001

DOI: 10.1021/acs.jmedchem.8b00650.s002

DOI: 10.1021/acs.jmedchem.8b00650.s003

DOI: 10.1021/acs.jmedchem.8b00650.s004

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2018

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

Pfefferkorn, Jeffrey A. ; Guzman-Perez, Angel ; Oates, Peter J. ; [et al.]

Royal Society of Chemistry (RSC) ; 2011

In: MedChemComm Vol. 2, No. 9 ( 2011), p. 828-

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In: MedChemComm, Royal Society of Chemistry (RSC), Vol. 2, No. 9 ( 2011), p. 828-

Type of Medium: Online Resource

ISSN: 2040-2503 , 2040-2511

URL: Article

DOI: 10.1039/c1md00116g

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2011

detail.hit.zdb_id: 2545949-1

detail.hit.zdb_id: 3005515-5

SSG: 15,3

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ChemInform Abstract: Regioselective Synthesis of 2H-Indazoles Using a Mild, One-Pot Condensation-Cadogan Reductive Cyclization.

Genung, Nathan E. ; Wei, Liuqing ; Aspnes, Gary E.

Wiley ; 2014

In: ChemInform Vol. 45, No. 49 ( 2014-12-09), p. no-no

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In: ChemInform, Wiley, Vol. 45, No. 49 ( 2014-12-09), p. no-no

Type of Medium: Online Resource

ISSN: 0931-7597

URL: Issue

URL: Article

DOI: 10.1002/chin.v45.49

DOI: 10.1002/chin.201449125

Language: English

Publisher: Wiley

Publication Date: 2014

detail.hit.zdb_id: 2110203-X

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Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9

Londregan, Allyn T. ; Aspnes, Gary ; Limberakis, Chris ; [et al.]

Elsevier BV ; 2018

In: Bioorganic & Medicinal Chemistry Letters Vol. 28, No. 23-24 ( 2018-12), p. 3685-3688

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 28, No. 23-24 ( 2018-12), p. 3685-3688

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2018.10.029

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus

Pfefferkorn, Jeffrey A. ; Tu, Meihua ; Filipski, Kevin J. ; [et al.]

Elsevier BV ; 2012

In: Bioorganic & Medicinal Chemistry Letters Vol. 22, No. 23 ( 2012-12), p. 7100-7105

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 22, No. 23 ( 2012-12), p. 7100-7105

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2012.09.082

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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Discovery of ( S )-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1 H -imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Pfefferkorn, Jeffrey A. ; Guzman-Perez, Angel ; Litchfield, John ; [et al.]

American Chemical Society (ACS) ; 2012

In: Journal of Medicinal Chemistry Vol. 55, No. 3 ( 2012-02-09), p. 1318-1333

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 55, No. 3 ( 2012-02-09), p. 1318-1333

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/jm2014887

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2012

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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