In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 6 ( 2021-6-18), p. e0253620-
Abstract:
Tourette syndrome is a neurodevelopmental disorder associated with hyperactivity in dopaminergic networks. Dopaminergic hyperactivity in the basal ganglia has previously been linked to increased sensitivity to positive reinforcement and increases in choice impulsivity. In this study, we examine whether this extends to changes in temporal discounting, where impulsivity is operationalized as an increased preference for smaller-but-sooner over larger-but-later rewards. We assessed intertemporal choice in two studies including nineteen adolescents (age: mean[sd] = 14.21[±2.37] , 13 male subjects) and twenty-five adult patients (age: mean[sd] = 29.88 [±9.03] ; 19 male subjects) with Tourette syndrome and healthy age- and education matched controls. Computational modeling using exponential and hyperbolic discounting models via hierarchical Bayesian parameter estimation revealed reduced temporal discounting in adolescent patients, and no evidence for differences in adult patients. Results are discussed with respect to neural models of temporal discounting, dopaminergic alterations in Tourette syndrome and the developmental trajectory of temporal discounting. Specifically, adolescents might show attenuated discounting due to improved inhibitory functions that also affect choice impulsivity and/or the developmental trajectory of executive control functions. Future studies would benefit from a longitudinal approach to further elucidate the developmental trajectory of these effects.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0253620
DOI:
10.1371/journal.pone.0253620.g001
DOI:
10.1371/journal.pone.0253620.g002
DOI:
10.1371/journal.pone.0253620.t001
DOI:
10.1371/journal.pone.0253620.t002
DOI:
10.1371/journal.pone.0253620.t003
DOI:
10.1371/journal.pone.0253620.s001
DOI:
10.1371/journal.pone.0253620.s002
DOI:
10.1371/journal.pone.0253620.s003
DOI:
10.1371/journal.pone.0253620.s004
DOI:
10.1371/journal.pone.0253620.s005
DOI:
10.1371/journal.pone.0253620.s006
DOI:
10.1371/journal.pone.0253620.s007
DOI:
10.1371/journal.pone.0253620.s008
DOI:
10.1371/journal.pone.0253620.s009
DOI:
10.1371/journal.pone.0253620.r001
DOI:
10.1371/journal.pone.0253620.r002
DOI:
10.1371/journal.pone.0253620.r003
DOI:
10.1371/journal.pone.0253620.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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