In:
European Journal of Organic Chemistry, Wiley, Vol. 2006, No. 12 ( 2006-06), p. 2715-2722
Abstract:
The highly fluorescent 6,7‐dimethoxy‐3‐trifluoromethylcarbostyril 2 was regioselectively carboxymethylated with bromoacetates 4 at N‐1 to give esters of type 5 in good yield. After saponification to 8 , succinimidoyl (OSu) esters 9 were prepared. Dyestuffs 9 were reacted in slightly basic aqueous media under mild conditions with free amino acids, esters and peptides to give the fluorescently labeled amino acid derivatives 11 and 13 in good yields. Similarly, aminoglucose and chitosane reacted to form the fluorescently labeled carbohydrates 15 and 17 . Fluorescence quantum yields of 0.3–0.4, their photostability and a pH‐independence between 3 and 10 make this class of compounds useful for linking to biological samples in aqueous media.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2006:12
DOI:
10.1002/ejoc.200500981
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
1475010-7
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