In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 8_Supplement ( 2011-04-15), p. 3907-3907
Abstract:
Background: Aging process modifies gene expression pattern and might be related to certain disease like cancer. As clinical outcome worsens with age, different molecular behavior of cancer between aging should be elucidated to accomplish future personalized medicine, especially in geriatric cancer patients. Methods: Primary gastric cancer tissues and corresponding normal mucosa were obtained from 81 patients. cDNA microarray analysis was performed using 14,125 probes. To select differentially expressed genes between aging, multiple regression model considering age, sex, stage, and pathology was applied. Functional study and pathway analysis was performed through database for annotation, visualization and integrated discovery (DAVID) and Ingenuity pathway analysis. Results: In normal tissues, two hundred and ninety-six genes were determined as aging-related genes that were involved in aging-process relation with mitochondria and ubiquitination. In tumor tissues, sixty-two genes were identified that showed significantly different expression according to age. Twenty genes were up-regulated and forty-two genes were down-regulated. Apoptosis (6 genes), carbohydrate metabolism (4 genes), cell cycle (8 genes), cellular proliferation (7 genes), DNA repair (3 genes), and inflammation (5 genes) were related. In pathway analysis with tumor tissues, gene expression was down-regulated with age in proliferation pathways including growth hormone, PI3K/Akt, TGF-β, and TNFR signaling. Furthermore, genes involved in tumor suppressor pathways involving apoptosis and PTEN were down-regulated in older tumors. Conclusions: As gastric cancer develops later, carcinogenesis is less dependent from proliferation, but also tumor suppressor pathways. Our results could be one explanation of less chemotherapy response and enhancing defense mechanism is needed in old-age gastric cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3907. doi:10.1158/1538-7445.AM2011-3907
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2011-3907
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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