In:
童綜合醫學雜誌, Medknow, Vol. 16, No. S ( 2022-09), p. 013-019
Abstract:
〈p〉Objective: This study investigated the association between uric acid and atherosclerosis in a community population. Methods: We enrolled 2,790 subjects aged ≥ 30 years from the CardioVascular Disease FACTor Two-Township Study. The common carotid artery intima-media thickness (IMT) and atherosclerotic plaque were used as indices of atherosclerosis. Pearson’s correlation coefficient, the general linear model, and a logistic model were used to assess the association between uric acid and atherosclerosis. Results: Elevated uric acid was moderately associated with obesity, dyslipidemia, elevated blood pressure, impaired glucose, insulin resistance (all correlation coefficients 〈 0.05) and IMT (r: 0.12, p 〈 0.05). Subjects were classified into four groups according to uric acid levels: group 1 (〈5.0 mg/dl), group 2 (5.0–6.9 mg/dl), group 3 (7.0–8.9 mg/dl) and group 4 (≥9.0 mg/dl). The age and sex-adjusted mean of IMT was 0.54 in group 1, was 0.55 in both groups 2 and 3, and the mean of IMT (0.59 mm) in group 4 (≥9.0 mg/dl) was significantly higher. Uric acid (≥9.0 mg/dl) was significantly and positively associated with higher IMT (multivariate adjusted mean: 0.58 mm), independent of other risk factors, and atherosclerosis (≥75th IMT value in the population) with an odds ratio of 2.67 (95% confidence intervals = 1.55–4.59). This association remained significant in a healthy subgroup (without metabolic syndrome, hypertension, or diabetes; OR = 2.91; CI = 1.16–7.25). Conclusion: Uric acid of 9 mg/dL and/or above was independently associated with atherosclerosis in terms of IMT measures in the general population and those without metabolic syndrome. Further study is warranted.〈/p〉
〈p〉 〈/p〉
Type of Medium:
Online Resource
ISSN:
2071-3592
,
2071-3592
Uniform Title:
Uric Acid is Independently Associated with Atherosclerosis among Healthy Chinese in Taiwan
DOI:
10.53106/20713592202209160S003
Language:
Unknown
Publisher:
Medknow
Publication Date:
2022
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