KOBV Portal

Hits per page

hits 1 - 10 | 161 hits

Sorting

Online Resource

Structural basis of nonhaemolytic nature of pneumolysin from strain ST-306

Badgujar, Dilip ; Anil, Anjali ; More, Prachi ; [et al.]

International Union of Crystallography (IUCr) ; 2017

In: Acta Crystallographica Section A Foundations and Advances Vol. 73, No. a2 ( 2017-12-01), p. C636-C636

add to watchlist on the watchlist

Details

In: Acta Crystallographica Section A Foundations and Advances, International Union of Crystallography (IUCr), Vol. 73, No. a2 ( 2017-12-01), p. C636-C636

Type of Medium: Online Resource

ISSN: 2053-2733

URL: Article

DOI: 10.1107/S2053273317089379

Language: Unknown

Publisher: International Union of Crystallography (IUCr)

Publication Date: 2017

detail.hit.zdb_id: 2020844-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

Badgujar, Dilip C. ; Anil, Anjali ; Green, Angharad E. ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS Pathogens Vol. 16, No. 11 ( 2020-11-20), p. e1009016-

add to watchlist on the watchlist

Details

In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 16, No. 11 ( 2020-11-20), p. e1009016-

Abstract: The opportunistic pathogen Streptococcus pneumoniae has dual lifestyles: one of an asymptomatic colonizer in the human nasopharynx and the other of a deadly pathogen invading sterile host compartments. The latter triggers an overwhelming inflammatory response, partly driven via pore forming activity of the cholesterol dependent cytolysin (CDC), pneumolysin. Although pneumolysin-induced inflammation drives person-to-person transmission from nasopharynx, the primary reservoir for pneumococcus, it also contributes to high mortality rates, creating a bottleneck that hampers widespread bacterial dissemination, thus acting as a double-edged sword. Serotype 1 ST306, a widespread pneumococcal clone, harbours a non-hemolytic variant of pneumolysin (Ply-NH). Performing crystal structure analysis of Ply-NH, we identified Y150H and T172I as key substitutions responsible for loss of its pore forming activity. We uncovered a novel inter-molecular cation-π interaction, governing formation of the transmembrane β-hairpins (TMH) in the pore state of Ply, which can be extended to other CDCs. H150 in Ply-NH disrupts this interaction, while I172 provides structural rigidity to domain-3, through hydrophobic interactions, inhibiting TMH formation. Loss of pore forming activity enabled improved cellular invasion and autophagy evasion, promoting an atypical intracellular lifestyle for pneumococcus, a finding that was corroborated in in vivo infection models. Attenuation of inflammatory responses and tissue damage promoted tolerance of Ply-NH-expressing pneumococcus in the lower respiratory tract. Adoption of this altered lifestyle may be necessary for ST306 due to its limited nasopharyngeal carriage, with Ply-NH, aided partly by loss of its pore forming ability, facilitating a benign association of SPN in an alternative, intracellular host niche.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1009016

DOI: 10.1371/journal.ppat.1009016.g001

DOI: 10.1371/journal.ppat.1009016.g002

DOI: 10.1371/journal.ppat.1009016.g003

DOI: 10.1371/journal.ppat.1009016.g004

DOI: 10.1371/journal.ppat.1009016.g005

DOI: 10.1371/journal.ppat.1009016.g006

DOI: 10.1371/journal.ppat.1009016.g007

DOI: 10.1371/journal.ppat.1009016.s001

DOI: 10.1371/journal.ppat.1009016.s002

DOI: 10.1371/journal.ppat.1009016.s003

DOI: 10.1371/journal.ppat.1009016.s004

DOI: 10.1371/journal.ppat.1009016.s005

DOI: 10.1371/journal.ppat.1009016.s006

DOI: 10.1371/journal.ppat.1009016.s007

DOI: 10.1371/journal.ppat.1009016.s008

DOI: 10.1371/journal.ppat.1009016.s009

DOI: 10.1371/journal.ppat.1009016.s010

DOI: 10.1371/journal.ppat.1009016.s011

DOI: 10.1371/journal.ppat.1009016.s012

DOI: 10.1371/journal.ppat.1009016.s013

DOI: 10.1371/journal.ppat.1009016.s014

DOI: 10.1371/journal.ppat.1009016.s015

DOI: 10.1371/journal.ppat.1009016.s016

DOI: 10.1371/journal.ppat.1009016.s017

DOI: 10.1371/journal.ppat.1009016.s018

DOI: 10.1371/journal.ppat.1009016.s019

DOI: 10.1371/journal.ppat.1009016.s020

DOI: 10.1371/journal.ppat.1009016.r001

DOI: 10.1371/journal.ppat.1009016.r002

DOI: 10.1371/journal.ppat.1009016.r003

DOI: 10.1371/journal.ppat.1009016.r004

DOI: 10.1371/journal.ppat.1009016.r005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2205412-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Alkylations of some cyclic β-keto esters with α-halo esters

Chatterjee, Amareshwar ; Banerjee, Dilip ; Banerjee, Somenath

Elsevier BV ; 1965

In: Tetrahedron Letters Vol. 6, No. 43 ( 1965-1), p. 3851-3860

add to watchlist on the watchlist

Details

In: Tetrahedron Letters, Elsevier BV, Vol. 6, No. 43 ( 1965-1), p. 3851-3860

Type of Medium: Online Resource

ISSN: 0040-4039

URL: Article

DOI: 10.1016/S0040-4039(01)89137-1

RVK:

VA 7560

Language: English

Publisher: Elsevier BV

Publication Date: 1965

detail.hit.zdb_id: 2007074-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Solid state M�ssbauer, e.p.r., magnetic properties and thermally induced stereochemical studies on double complex salts of cyclic diamine containing cationic copper(II) complexes and a hexacyanoferrate(III) anion

Kundu, Parimal ; Mitra, Samiran ; Kumar, Sonjay ; [et al.]

Springer Science and Business Media LLC ; 1995

In: Transition Metal Chemistry Vol. 20, No. 5 ( 1995-10), p. 417-422

add to watchlist on the watchlist

Details

In: Transition Metal Chemistry, Springer Science and Business Media LLC, Vol. 20, No. 5 ( 1995-10), p. 417-422

Type of Medium: Online Resource

ISSN: 0340-4285 , 1572-901X

URL: Article

DOI: 10.1007/BF00141508

RVK:

VH 7900

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 1995

detail.hit.zdb_id: 1501083-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Rapid estimation of piperine in black pepper: Exploration of Raman spectroscopy

Sing, Dilip ; Jana, Shibu Narayan ; Banerjee, Subhadip ; [et al.]

Wiley ; 2022

In: Phytochemical Analysis Vol. 33, No. 2 ( 2022-03), p. 204-213

add to watchlist on the watchlist

Details

In: Phytochemical Analysis, Wiley, Vol. 33, No. 2 ( 2022-03), p. 204-213

Abstract: This work highlights on quantification of piperine in Piper nigrum by a rapid, noninvasive Raman spectroscopic method using statistically significant samples with comparable precision of HPLC analysis. We have studied Raman shift for piperine molecule with the density functional theory (DFT) to understand structural basis of experiment and theoretical shifts. Finally, pre‐processing and chemometric classification tools like PCA, LDA, SI, and partial least square regression (PLSR) was used for spectral analysis and quantitative assessment of piperine in Piper nigrum samples.

Type of Medium: Online Resource

ISSN: 0958-0344 , 1099-1565

URL: Issue

URL: Article

DOI: 10.1002/pca.v33.2

DOI: 10.1002/pca.3080

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 1498615-2

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A software independent tool for mapping thermal results to structural model

Banerjee, Dilip K.

Elsevier BV ; 2014

In: Fire Safety Journal Vol. 68 ( 2014-08), p. 1-15

add to watchlist on the watchlist

Details

In: Fire Safety Journal, Elsevier BV, Vol. 68 ( 2014-08), p. 1-15

Type of Medium: Online Resource

ISSN: 0379-7112

URL: Article

DOI: 10.1016/j.firesaf.2014.06.002

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 1483569-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Coexisting arc and MORB signatures in the Sonakhan greenstone belt, India: late Neoarchean – early Proterozoic subduction rollback and back-arc formation

Deb, Gautam Kumar ; Saha, Dilip ; Patranabis-Deb, Sarbani ; [et al.]

American Journal of Science (AJS) ; 2021

In: American Journal of Science Vol. 321, No. 9 ( 2021-11), p. 1308-1349

add to watchlist on the watchlist

Details

In: American Journal of Science, American Journal of Science (AJS), Vol. 321, No. 9 ( 2021-11), p. 1308-1349

Type of Medium: Online Resource

ISSN: 0002-9599 , 1945-452X

URL: Article

DOI: 10.2475/09.2021.02

RVK:

TA 1000

Language: English

Publisher: American Journal of Science (AJS)

Publication Date: 2021

detail.hit.zdb_id: 2065810-2

detail.hit.zdb_id: 2534734-2

SSG: 13

SSG: 25

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Differential expression of mycobacterial proteins following phagocytosis by macrophages

Monahan, Irene M. ; Betts, Joanna ; Banerjee, Dilip K. ; [et al.]

Microbiology Society ; 2001

In: Microbiology Vol. 147, No. 2 ( 2001-02-01), p. 459-471

add to watchlist on the watchlist

Details

In: Microbiology, Microbiology Society, Vol. 147, No. 2 ( 2001-02-01), p. 459-471

Type of Medium: Online Resource

ISSN: 1350-0872 , 1465-2080

URL: Article

DOI: 10.1099/00221287-147-2-459

Language: English

Publisher: Microbiology Society

Publication Date: 2001

detail.hit.zdb_id: 2008736-6

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Discovery of Potent, Selective, and State-Dependent NaV1.7 Inhibitors with Robust Oral Efficacy in Pain Models: StructureActivity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides

Ramdas, Vidya ; Talwar, Rashmi ; Kanoje, Vijay ; [et al.]

American Chemical Society (ACS) ; 2020

In: Journal of Medicinal Chemistry Vol. 63, No. 11 ( 2020-06-11), p. 6107-6133

add to watchlist on the watchlist

Details

In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 63, No. 11 ( 2020-06-11), p. 6107-6133

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/acs.jmedchem.0c00361

DOI: 10.1021/acs.jmedchem.0c00361.s001

DOI: 10.1021/acs.jmedchem.0c00361.s002

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2020

detail.hit.zdb_id: 1491411-6

SSG: 15,3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Quantitative magnetic resonance imaging predicts individual future liver performance after liver reception for cancer

Mole, Damian ; Fallowfield, Jonathan ; Welsh, Fenella ; [et al.]

Elsevier BV ; 2020

In: Journal of Hepatology Vol. 73 ( 2020-08), p. S380-

add to watchlist on the watchlist

Details

In: Journal of Hepatology, Elsevier BV, Vol. 73 ( 2020-08), p. S380-

Type of Medium: Online Resource

ISSN: 0168-8278

URL: Article

DOI: 10.1016/S0168-8278(20)31252-6

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2027112-8

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 161 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg