In:
Public Health Nutrition, Cambridge University Press (CUP), Vol. 20, No. 10 ( 2017-07), p. 1865-1873
Abstract:
To determine the effect of prenatal maternal vitamin D supplementation on infant vitamin D status in a tropical region where vitamin D supplementation is not routine. Design A prospective observational follow-up of a randomized trial. Setting Maternal–child health facility in Dhaka, Bangladesh (23°N). Subjects Infants born to pregnant women ( n 160) randomized to receive 875 µg (35 000 IU) cholecalciferol (vitamin D 3 ) per week (VD) or placebo (PL) during the third trimester were followed from birth until 6 months of age ( n 115). Infant serum 25-hydroxyvitamin D concentration (25(OH)D) was measured at 〈 1, 2, 4 and 6 months of age. Results Mean infant 25(OH)D was higher in the VD v . PL group at 〈 1 month of age (mean ( sd ): 80 (20) nmol/l v . 22 (18) nmol/l; P 〈 0·001), but the difference was attenuated by 2 months (52 (19) nmol/l v . 40 (23) nmol/l; P= 0·05). Groups were similar at 4 months ( P= 0·40) and 6 months ( n 72; P= 0·26). In the PL group, mean infant 25(OH)D increased to 78 (95 % CI 67, 88) nmol/l by 6 months of age ( n 34). 25(OH)D was higher with infant formula-feeding and higher in summer v . winter. Conclusions Prenatal third-trimester vitamin D supplementation (875 µg (35 000 IU)/week) significantly ameliorated infant vitamin D status during the neonatal period when the risk of vitamin D deficiency is greatest. Further research is warranted to determine factors that contribute to the rise in 25(OH)D during the first 6 months of life among breast-fed infants in this setting.
Type of Medium:
Online Resource
ISSN:
1368-9800
,
1475-2727
DOI:
10.1017/S1368980015003092
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2017
detail.hit.zdb_id:
2016337-X
SSG:
21
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