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Ultrastructure of the Antennae and Sensilla of Nyssomyia intermedia (Diptera: Psychodidae), Vector of American Cutaneous Leishmaniasis

Fernandes, Fernando de Freitas ; Barletta, Ana Beatriz F ; Orfanó, Alessandra S ; [et al.]

Oxford University Press (OUP) ; 2020

In: Journal of Medical Entomology Vol. 57, No. 6 ( 2020-11-13), p. 1722-1734

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In: Journal of Medical Entomology, Oxford University Press (OUP), Vol. 57, No. 6 ( 2020-11-13), p. 1722-1734

Abstract: The antennal sensilla and the antenna of females Nyssomyia intermedia, one of the main vectors of American cutaneous leishmaniasis, were studied by scanning electron microscopy. The main goal was to characterize the quantity, typology, and topography of the sensilla with particular attention to the olfactory types. The insects were captured in the city of Corte de Pedra, State of Bahia, Brazil, by CDC-type light traps and raised in a laboratory as a new colony. Fourteen well-differentiated sensilla were identified, among six cuticular types: trichoidea, campaniformia, squamiformia, basiconica, chaetica, and coeloconica. Of these, six sensilla were classified as olfactory sensilla due to their specific morphological features. Smaller noninnervated pilosities of microtrichiae type were also evidenced by covering all antennal segments. The antennal segments differ in shapes and sizes, and the amount and distribution of types and subtypes of sensilla. This study may foment future taxonomic and phylogenetic analysis for a better evolutionary understanding of the sand flies. Besides, it may assist the targeting of future electrophysiological studies by Single Sensillum Recording, and aim to develop alternative measures of monitoring and control of this vector.

Type of Medium: Online Resource

ISSN: 0022-2585 , 1938-2928

URL: Article

DOI: 10.1093/jme/tjaa124

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2020

detail.hit.zdb_id: 2031006-7

SSG: 12

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Corrigendum to: Morphological Characterization of the Antennal Sensilla of the Afrotropical Sand Fly, Phlebotomus duboscqi (Diptera: Psychodidae)

Bahia, Ana Cristina ; Barletta, Ana Beatriz F ; Pinto, Luciana Conceição ; [et al.]

Oxford University Press (OUP) ; 2022

In: Journal of Medical Entomology Vol. 59, No. 1 ( 2022-01-12), p. 400-400

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In: Journal of Medical Entomology, Oxford University Press (OUP), Vol. 59, No. 1 ( 2022-01-12), p. 400-400

Type of Medium: Online Resource

ISSN: 0022-2585 , 1938-2928

URL: Article

DOI: 10.1093/jme/tjab185

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2022

detail.hit.zdb_id: 2031006-7

SSG: 12

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Editorial: Parasite interactions with insect hosts in tropical diseases

Bahia, Ana C. ; Barletta, Ana Beatriz F. ; Lopes, Angela H. ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Tropical Diseases Vol. 3 ( 2022-8-17)

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In: Frontiers in Tropical Diseases, Frontiers Media SA, Vol. 3 ( 2022-8-17)

Type of Medium: Online Resource

ISSN: 2673-7515

URL: Article

DOI: 10.3389/fitd.2022.992277

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 3097199-8

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Morphological Characterization of the Antennal Sensilla of the Afrotropical Sand Fly, Phlebotomus duboscqi (Diptera: Psychodidae)

Bahia, Ana Cristina ; Barletta, Ana Beatriz F ; Pinto, Luciana Conceição ; [et al.]

Oxford University Press (OUP) ; 2021

In: Journal of Medical Entomology Vol. 58, No. 2 ( 2021-03-12), p. 634-645

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In: Journal of Medical Entomology, Oxford University Press (OUP), Vol. 58, No. 2 ( 2021-03-12), p. 634-645

Abstract: We investigated by scanning electron microscopy the morphology, distribution, and abundance of antennal sensilla of females Phlebotomus duboscqi sand fly, an important vector of zoonotic cutaneous leishmaniasis at Afrotropical region. Thirteen well-differentiated sensilla were identified, among six types of cuticular sensilla. The probable function of these sensillary types is discussed in relation to their external structure and distribution. Five sensillary types were classified as olfactory sensilla, as they have specific morphological characters of sensilla with this function. Number and distribution of sensilla significantly differed between antennal segments. The results of the present work, besides corroborating in the expansion of the morphological and ultrastructural knowledge of P. duboscqi, can foment future electrophysiological studies for the development of volatile semiochemicals, to be used as attractants in traps for monitoring and selective vector control of this sand fly.

Type of Medium: Online Resource

ISSN: 0022-2585 , 1938-2928

URL: Article

DOI: 10.1093/jme/tjaa247

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2021

detail.hit.zdb_id: 2031006-7

SSG: 12

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Activation of innate immunity selectively compromises mitochondrial complex I, proline oxidation, and flight activity in the major arbovirus vector Aedes aegypti

Gaviraghi, Alessandro ; Barletta, Ana Beatriz F. ; Silva, Thiago Luiz Alves E. ; [et al.]

Wiley ; 2024

In: Molecular Microbiology

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In: Molecular Microbiology, Wiley

Abstract: Aedes aegypti females are natural vectors of important arboviruses such as dengue, zika, and yellow fever. Mosquitoes activate innate immune response signaling pathways upon infection, as a resistance mechanism to fight pathogens and limit their propagation. Despite the beneficial effects of immune activation for insect vectors, phenotypic costs ultimately affect their fitness. However, the underlying mechanisms that mediate these fitness costs remain poorly understood. Given the high energy required to mount a proper immune response, we hypothesized that systemic activation of innate immunity would impair flight muscle mitochondrial function, compromising tissue energy demand and flight activity. Here, we investigated the dynamic effects of activation of innate immunity by intra‐thoracic zymosan injection on A. aegypti flight muscle mitochondrial metabolism. Zymosan injection significantly increased defensin A expression in fat bodies in a time‐dependent manner that compromised flight activity. Although oxidant levels in flight muscle were hardly altered, ATP‐linked respiratory rates driven by mitochondrial pyruvate+proline oxidation were significantly reduced at 24 h upon zymosan injection. Oxidative phosphorylation coupling was preserved regardless of innate immune response activation along 24 h. Importantly, rotenone‐sensitive respiration and complex I‐III activity were specifically reduced 24 h upon zymosan injection. Also, loss of complex I activity compromised ATP‐linked and maximal respiratory rates mediated by mitochondrial proline oxidation. Finally, the magnitude of innate immune response activation negatively correlated with respiratory rates, regardless of the metabolic states. Collectively, we demonstrate that activation of innate immunity is strongly associated with reduced flight muscle complex I activity with direct consequences to mitochondrial proline oxidation and flight activity. Remarkably, our results indicate a trade‐off between dispersal and immunity exists in an insect vector, underscoring the potential consequences of disrupted flight muscle mitochondrial energy metabolism to arbovirus transmission.

Type of Medium: Online Resource

ISSN: 0950-382X , 1365-2958

URL: Article

DOI: 10.1111/mmi.15269

Language: English

Publisher: Wiley

Publication Date: 2024

detail.hit.zdb_id: 1501537-3

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A mosquito juvenile hormone binding protein (mJHBP) regulates the activation of innate immune defenses and hemocyte development

Kim, Il Hwan ; Castillo, Julio César ; Aryan, Azadeh ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS Pathogens Vol. 16, No. 1 ( 2020-1-21), p. e1008288-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2020-1-21), p. e1008288-

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1008288

DOI: 10.1371/journal.ppat.1008288.g001

DOI: 10.1371/journal.ppat.1008288.g002

DOI: 10.1371/journal.ppat.1008288.g003

DOI: 10.1371/journal.ppat.1008288.g004

DOI: 10.1371/journal.ppat.1008288.g005

DOI: 10.1371/journal.ppat.1008288.g006

DOI: 10.1371/journal.ppat.1008288.g007

DOI: 10.1371/journal.ppat.1008288.g008

DOI: 10.1371/journal.ppat.1008288.g009

DOI: 10.1371/journal.ppat.1008288.s001

DOI: 10.1371/journal.ppat.1008288.s002

DOI: 10.1371/journal.ppat.1008288.s003

DOI: 10.1371/journal.ppat.1008288.s004

DOI: 10.1371/journal.ppat.1008288.s005

DOI: 10.1371/journal.ppat.1008288.s006

DOI: 10.1371/journal.ppat.1008288.s007

DOI: 10.1371/journal.ppat.1008288.s008

DOI: 10.1371/journal.ppat.1008288.s009

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2205412-1

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The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme–induced peroxidase

Talyuli, Octavio A. C. ; Oliveira, Jose Henrique M. ; Bottino-Rojas, Vanessa ; [et al.]

Public Library of Science (PLoS) ; 2023

In: PLOS Pathogens Vol. 19, No. 2 ( 2023-2-13), p. e1011149-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 19, No. 2 ( 2023-2-13), p. e1011149-

Abstract: Aedes aegypti mosquitoes are the main vectors of arboviruses. The peritrophic matrix (PM) is an extracellular layer that surrounds the blood bolus. It acts as an immune barrier that prevents direct contact of bacteria with midgut epithelial cells during blood digestion. Here, we describe a heme-dependent peroxidase, hereafter referred to as heme peroxidase 1 (HPx1). HPx1 promotes PM assembly and antioxidant ability, modulating vector competence. Mechanistically, the heme presence in a blood meal induces HPx1 transcriptional activation mediated by the E75 transcription factor. HPx1 knockdown increases midgut reactive oxygen species (ROS) production by the DUOX NADPH oxidase. Elevated ROS levels reduce microbiota growth while enhancing epithelial mitosis, a response to tissue damage. However, simultaneous HPx1 and DUOX silencing was not able to rescue bacterial population growth, as explained by increased expression of antimicrobial peptides (AMPs), which occurred only after double knockdown. This result revealed hierarchical activation of ROS and AMPs to control microbiota. HPx1 knockdown produced a 100-fold decrease in Zika and dengue 2 midgut infection, demonstrating the essential role of the mosquito PM in the modulation of arbovirus vector competence. Our data show that the PM connects blood digestion to midgut immunological sensing of the microbiota and viral infections.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1011149

DOI: 10.1371/journal.ppat.1011149.g001

DOI: 10.1371/journal.ppat.1011149.g002

DOI: 10.1371/journal.ppat.1011149.g003

DOI: 10.1371/journal.ppat.1011149.g004

DOI: 10.1371/journal.ppat.1011149.g005

DOI: 10.1371/journal.ppat.1011149.s001

DOI: 10.1371/journal.ppat.1011149.s002

DOI: 10.1371/journal.ppat.1011149.s003

DOI: 10.1371/journal.ppat.1011149.s004

DOI: 10.1371/journal.ppat.1011149.s005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2023

detail.hit.zdb_id: 2205412-1

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Mosquito cellular immunity at single-cell resolution

Raddi, Gianmarco ; Barletta, Ana Beatriz F. ; Efremova, Mirjana ; [et al.]

American Association for the Advancement of Science (AAAS) ; 2020

In: Science Vol. 369, No. 6507 ( 2020-08-28), p. 1128-1132

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In: Science, American Association for the Advancement of Science (AAAS), Vol. 369, No. 6507 ( 2020-08-28), p. 1128-1132

Abstract: Hemocytes limit the capacity of mosquitoes to transmit human pathogens. Here we profile the transcriptomes of 8506 hemocytes of Anopheles gambiae and Aedes aegypti mosquito vectors. Our data reveal the functional diversity of hemocytes, with different subtypes of granulocytes expressing distinct and evolutionarily conserved subsets of effector genes. A previously unidentified cell type in An. gambiae , which we term “megacyte,” is defined by a specific transmembrane protein marker (TM7318) and high expression of lipopolysaccharide-induced tumor necrosis factor–α transcription factor 3 (LL3). Knockdown experiments indicate that LL3 mediates hemocyte differentiation during immune priming. We identify and validate two main hemocyte lineages and find evidence of proliferating granulocyte populations. This atlas of medically relevant invertebrate immune cells at single-cell resolution identifies cellular events that underpin mosquito immunity to malaria infection.

Type of Medium: Online Resource

ISSN: 0036-8075 , 1095-9203

URL: Article

DOI: 10.1126/science.abc0322

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 2020

detail.hit.zdb_id: 128410-1

detail.hit.zdb_id: 2066996-3

detail.hit.zdb_id: 2060783-0

SSG: 11

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Human norovirus targets enteroendocrine epithelial cells in the small intestine

Green, Kim Y. ; Kaufman, Stuart S. ; Nagata, Bianca M. ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Nature Communications Vol. 11, No. 1 ( 2020-06-02)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2020-06-02)

Abstract: Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected throughout the small intestinal tract in jejunal and ileal tissue from one pediatric intestinal transplant recipient with severe gastroenteritis. Negative-sense viral RNA, a marker of active viral replication, is found predominantly in intestinal epithelial cells, with chromogranin A-positive enteroendocrine cells (EECs) identified as a permissive cell type in this patient. These findings are consistent with the detection of norovirus-positive EECs in the other three immunocompromised patients. Investigation of the signaling pathways induced in EECs that mediate communication between the gut and brain may clarify mechanisms of pathogenesis and lead to the development of in vitro model systems in which to evaluate norovirus vaccines and treatment.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-020-16491-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2553671-0

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Data_Sheet_1.PDF

Yenkoidiok-Douti, Lampouguin ; Canepa, Gaspar E. ; Barletta, Ana Beatriz F. ; [et al.]

Frontiers Media SA ; 2020

In: Frontiers in Microbiology Vol. 11 ( 2020-7-3)

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In: Frontiers in Microbiology, Frontiers Media SA, Vol. 11 ( 2020-7-3)

Type of Medium: Online Resource

ISSN: 1664-302X

URL: Article

DOI: 10.3389/fmicb.2020.01496

DOI: 10.3389/fmicb.2020.01496.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2020

detail.hit.zdb_id: 2587354-4

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