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Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Horsburgh, Karen ; Wardlaw, Joanna M. ; van Agtmael, Tom ; [et al.]

Portland Press Ltd. ; 2018

In: Clinical Science Vol. 132, No. 8 ( 2018-04-30), p. 851-868

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In: Clinical Science, Portland Press Ltd., Vol. 132, No. 8 ( 2018-04-30), p. 851-868

Abstract: Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

Type of Medium: Online Resource

ISSN: 0143-5221 , 1470-8736

URL: Article

DOI: 10.1042/CS20171620

Language: English

Publisher: Portland Press Ltd.

Publication Date: 2018

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Drivers of Resistance in Uganda and Malawi (DRUM): a protocol for the evaluation of One-Health drivers of Extended Spectrum Beta Lactamase (ESBL) resistance in Low-Middle Income Countries (LMICs)

Cocker, Derek ; Sammarro, Melodie ; Chidziwisano, Kondwani ; [et al.]

F1000 Research Ltd ; 2023

In: Wellcome Open Research Vol. 7 ( 2023-5-2), p. 55-

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In: Wellcome Open Research, F1000 Research Ltd, Vol. 7 ( 2023-5-2), p. 55-

Type of Medium: Online Resource

ISSN: 2398-502X

URL: Journal

URL: Article

DOI: 10.12688/wellcomeopenres

DOI: 10.12688/wellcomeopenres.17581.2

Language: English

Publisher: F1000 Research Ltd

Publication Date: 2023

detail.hit.zdb_id: 2874778-1

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Innovating team-based outpatient mental health care in the Veterans Health Administration: Staff-perceived benefits and challenges to pilot implementation of the Behavioral Health Interdisciplinary Program (BHIP).

Barry, Catherine N. ; Abraham, Kristen M. ; Weaver, Kendra R. ; [et al.]

American Psychological Association (APA) ; 2016

In: Psychological Services Vol. 13, No. 2 ( 2016-05), p. 148-155

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In: Psychological Services, American Psychological Association (APA), Vol. 13, No. 2 ( 2016-05), p. 148-155

Type of Medium: Online Resource

ISSN: 1939-148X , 1541-1559

URL: Article

DOI: 10.1037/ser0000072

Language: English

Publisher: American Psychological Association (APA)

Publication Date: 2016

detail.hit.zdb_id: 2156662-8

SSG: 5,2

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The Real-World Effect of Intravitreous Anti–Vascular Endothelial Growth Factor Drugs on Intraocular Pressure

Atchison, Elizabeth A. ; Wood, Kevin M. ; Mattox, Cynthia G. ; [et al.]

Elsevier BV ; 2018

In: Ophthalmology Vol. 125, No. 5 ( 2018-05), p. 676-682

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In: Ophthalmology, Elsevier BV, Vol. 125, No. 5 ( 2018-05), p. 676-682

Type of Medium: Online Resource

ISSN: 0161-6420

URL: Article

DOI: 10.1016/j.ophtha.2017.11.027

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2018

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Use of the Columbia‐Suicide Severity Rating Scale (C‐ SSRS ) in a large sample of Veterans receiving mental health services in the Veterans Health Administration

Katz, Ira ; Barry, Catherine N. ; Cooper, Samantha A. ; [et al.]

Wiley ; 2020

In: Suicide and Life-Threatening Behavior Vol. 50, No. 1 ( 2020-02), p. 111-121

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In: Suicide and Life-Threatening Behavior, Wiley, Vol. 50, No. 1 ( 2020-02), p. 111-121

Abstract: To evaluate the associations of self‐reports of suicidal ideation and behavior using the Columbia‐Suicide Severity Rating Scale (C‐ SSRS ) in a survey of patients receiving mental health services in the Veterans Health Administration ( VHA ) with reports of attempts documented in medical records and administrative data. Method The C‐ SSRS was administered to 15,373 Veterans in the Veterans Outcome Assessment ( VOA ) survey. Concurrent validity was evaluated by comparing self‐reports from the past 3 months with VHA records. Predictive validity was evaluated by logistic regression models using attempts over the subsequent 3 months as the outcome. Results Tests of concurrent validity found strong associations between self‐reports and attempts documented in VHA records, but there were substantial numbers of discordant responses. In tests of predictive validity, area under the ROC curve for predicting future attempts was 〉 0.8. There were differences in the distribution of responses and of psychometric properties across VHA mental health programs. Conclusions Findings support the value of screening and the validity of the self‐reports based on the C‐ SSRS , but limitations in concordance with medical records and variability across programs suggest the need for clinical judgment in interpreting responses.

Type of Medium: Online Resource

ISSN: 0363-0234 , 1943-278X

URL: Issue

URL: Article

DOI: 10.1111/sltb.v50.1

DOI: 10.1111/sltb.12584

Language: English

Publisher: Wiley

Publication Date: 2020

detail.hit.zdb_id: 2045937-3

SSG: 2,1

SSG: 5,2

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Drivers of Resistance in Uganda and Malawi (DRUM): a protocol for the evaluation of One-Health drivers of Extended Spectrum Beta Lactamase (ESBL) resistance in Low-Middle Income Countries (LMICs)

Cocker, Derek ; Sammarro, Melodie ; Chidziwisano, Kondwani ; [et al.]

F1000 Research Ltd ; 2022

In: Wellcome Open Research Vol. 7 ( 2022-2-15), p. 55-

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In: Wellcome Open Research, F1000 Research Ltd, Vol. 7 ( 2022-2-15), p. 55-

Type of Medium: Online Resource

ISSN: 2398-502X

URL: Journal

URL: Article

DOI: 10.12688/wellcomeopenres

DOI: 10.12688/wellcomeopenres.17581.1

Language: English

Publisher: F1000 Research Ltd

Publication Date: 2022

detail.hit.zdb_id: 2874778-1

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An Update on the Quality of Medication Treatment for Mental Disorders in the VA

Barry, Catherine N. ; Bowe, Thomas R. ; Suneja, Anecia

American Psychiatric Association Publishing ; 2016

In: Psychiatric Services Vol. 67, No. 8 ( 2016-08), p. 930-930

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In: Psychiatric Services, American Psychiatric Association Publishing, Vol. 67, No. 8 ( 2016-08), p. 930-930

Type of Medium: Online Resource

ISSN: 1075-2730 , 1557-9700

URL: Article

DOI: 10.1176/appi.ps.670804

Language: English

Publisher: American Psychiatric Association Publishing

Publication Date: 2016

detail.hit.zdb_id: 2022142-3

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Protocol: examining the effectiveness of an adaptive implementation intervention to improve uptake of the VA suicide risk identification strategy: a sequential multiple assignment randomized trial

Bahraini, Nazanin H. ; Matarazzo, Bridget B. ; Barry, Catherine N. ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Implementation Science Vol. 15, No. 1 ( 2020-12)

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In: Implementation Science, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2020-12)

Abstract: In 2018, the Veterans Health Administration (VHA) mandated implementation of a national suicide risk identification strategy (Risk ID). The goal of Risk ID is to improve the detection and management of suicide risk by standardizing suicide risk screening and evaluation enterprise-wide. In order to ensure continuous quality improvement (QI), ongoing evaluation and targeted interventions to improve implementation of Risk ID are needed. Moreover, given that facilities will vary with respect to implementation needs and barriers, the dose and type of intervention needed may vary across facilities. Thus, the objective of this study is to examine the effectiveness of an adaptive implementation strategy to improve the uptake of suicide risk screening and evaluation in VHA ambulatory care settings. In addition, this study will examine specific factors that may impact the uptake of suicide risk screening and evaluation and the adoption of different implementation strategies. This protocol describes the stepped implementation approach and proposed evaluation plan. Methods Using a sequential multiple assignment randomized trial (SMART) design, two evidence-based implementation strategies will be evaluated: (1) audit and feedback (A & F); (2) A & F plus external facilitation (A & F + EF). Implementation outcomes of interest include uptake of secondary suicide risk screening and uptake of comprehensive suicide risk evaluation (stages 2 and 3 of Risk ID). Secondary outcomes include rates of other clinical outcomes (i.e., safety planning) and organizational factors that may impact Risk ID implementation (i.e., leadership climate and leadership support). Discussion This national QI study will use a SMART design to evaluate whether an adaptive implementation strategy is effective in improving uptake of a mandated VHA-wide suicide risk screening and evaluation initiative. If this study finds that the proposed stepped implementation strategy is effective at increasing uptake and maintaining performance improvements, this approach may be used as an overarching QI strategy for other national suicide prevention programs. Trial registration ClinicalTrials.gov NCT04243330 . Registered 28 January 2020

Type of Medium: Online Resource

ISSN: 1748-5908

URL: Article

DOI: 10.1186/s13012-020-01019-6

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2225822-X

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Generalizing the Value of Ongoing Assessments of Suicidal Ideation or Behavior for Estimating the Risk of Subsequent Suicide Attempts

Katz, Ira ; Barry, Catherine N. ; Cooper, Samantha A. ; [et al.]

Informa UK Limited ; 2021

In: Archives of Suicide Research Vol. 25, No. 1 ( 2021-01-02), p. 115-125

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In: Archives of Suicide Research, Informa UK Limited, Vol. 25, No. 1 ( 2021-01-02), p. 115-125

Type of Medium: Online Resource

ISSN: 1381-1118 , 1543-6136

URL: Article

DOI: 10.1080/13811118.2019.1661897

Language: English

Publisher: Informa UK Limited

Publication Date: 2021

detail.hit.zdb_id: 2003544-5

SSG: 2,1

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Choice of method of place cell classification determines the population of cells identified

Grijseels, Dori M. ; Shaw, Kira ; Barry, Caswell ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Computational Biology Vol. 17, No. 7 ( 2021-7-8), p. e1008835-

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In: PLOS Computational Biology, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2021-7-8), p. e1008835-

Abstract: Place cells, spatially responsive hippocampal cells, provide the neural substrate supporting navigation and spatial memory. Historically most studies of these neurons have used electrophysiological recordings from implanted electrodes but optical methods, measuring intracellular calcium, are becoming increasingly common. Several methods have been proposed as a means to identify place cells based on their calcium activity but there is no common standard and it is unclear how reliable different approaches are. Here we tested four methods that have previously been applied to two-photon hippocampal imaging or electrophysiological data, using both model datasets and real imaging data. These methods use different parameters to identify place cells, including the peak activity in the place field, compared to other locations (the Peak method); the stability of cells’ activity over repeated traversals of an environment (Stability method); a combination of these parameters with the size of the place field (Combination method); and the spatial information held by the cells (Information method). The methods performed differently from each other on both model and real data. In real datasets, vastly different numbers of place cells were identified using the four methods, with little overlap between the populations identified as place cells. Therefore, choice of place cell detection method dramatically affects the number and properties of identified cells. Ultimately, we recommend the Peak method be used in future studies to identify place cell populations, as this method is robust to moderate variations in place field within a session, and makes no inherent assumptions about the spatial information in place fields, unless there is an explicit theoretical reason for detecting cells with more narrowly defined properties.

Type of Medium: Online Resource

ISSN: 1553-7358

URL: Article

DOI: 10.1371/journal.pcbi.1008835

DOI: 10.1371/journal.pcbi.1008835.g001

DOI: 10.1371/journal.pcbi.1008835.g002

DOI: 10.1371/journal.pcbi.1008835.g003

DOI: 10.1371/journal.pcbi.1008835.g004

DOI: 10.1371/journal.pcbi.1008835.g005

DOI: 10.1371/journal.pcbi.1008835.g006

DOI: 10.1371/journal.pcbi.1008835.s001

DOI: 10.1371/journal.pcbi.1008835.s002

DOI: 10.1371/journal.pcbi.1008835.s003

DOI: 10.1371/journal.pcbi.1008835.s004

DOI: 10.1371/journal.pcbi.1008835.s005

DOI: 10.1371/journal.pcbi.1008835.s006

DOI: 10.1371/journal.pcbi.1008835.s007

DOI: 10.1371/journal.pcbi.1008835.s008

DOI: 10.1371/journal.pcbi.1008835.s009

DOI: 10.1371/journal.pcbi.1008835.s010

DOI: 10.1371/journal.pcbi.1008835.r001

DOI: 10.1371/journal.pcbi.1008835.r002

DOI: 10.1371/journal.pcbi.1008835.r003

DOI: 10.1371/journal.pcbi.1008835.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2193340-6

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