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MPSA abstracts

Aminlari, Mahmoud ; Asquith, Thomas ; Sarlo, Katherine ; [et al.]

Springer Science and Business Media LLC ; 1994

In: Journal of Protein Chemistry Vol. 13, No. 5 ( 1994-07), p. 515-543

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In: Journal of Protein Chemistry, Springer Science and Business Media LLC, Vol. 13, No. 5 ( 1994-07), p. 515-543

Type of Medium: Online Resource

ISSN: 0277-8033 , 1573-4943

URL: Article

DOI: 10.1007/BF01898856

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 1994

detail.hit.zdb_id: 2017225-4

detail.hit.zdb_id: 2143071-8

SSG: 12

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BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project

Hudson, Lawrence N. ; Newbold, Tim ; Contu, Sara ; [et al.]

Wiley ; 2017

In: Ecology and Evolution Vol. 7, No. 1 ( 2017-01), p. 145-188

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In: Ecology and Evolution, Wiley, Vol. 7, No. 1 ( 2017-01), p. 145-188

Abstract: The PREDICTS project—Projecting Responses of Ecological Diversity In Changing Terrestrial Systems ( https://www.nhm.ac.uk/our-science/our-work/biodiversity/predicts.html )—has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.

Type of Medium: Online Resource

ISSN: 2045-7758 , 2045-7758

URL: Issue

URL: Article

DOI: 10.1002/ece3.2017.7.issue-1

DOI: 10.1002/ece3.2579

Language: English

Publisher: Wiley

Publication Date: 2017

detail.hit.zdb_id: 2635675-2

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BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

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Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

Todd Milne, G. ; on behalf of the Ironwood team ; Sandner, Peter ; [et al.]

Springer Science and Business Media LLC ; 2017

In: BMC Pharmacology and Toxicology Vol. 18, No. S1 ( 2017-10)

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In: BMC Pharmacology and Toxicology, Springer Science and Business Media LLC, Vol. 18, No. S1 ( 2017-10)

Type of Medium: Online Resource

ISSN: 2050-6511

URL: Article

DOI: 10.1186/s40360-017-0170-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2680259-4

SSG: 15,3

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Wissenschaftspark Albert Einstein

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FH Potsdam

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The 13th Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-IV Survey Mapping Nearby Galaxies at Apache Point Observatory

Albareti, Franco D. ; Prieto, Carlos Allende ; Almeida, Andres ; [et al.]

American Astronomical Society ; 2017

In: The Astrophysical Journal Supplement Series Vol. 233, No. 2 ( 2017-12-08), p. 25-

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In: The Astrophysical Journal Supplement Series, American Astronomical Society, Vol. 233, No. 2 ( 2017-12-08), p. 25-

Type of Medium: Online Resource

ISSN: 1538-4365

URL: Article

DOI: 10.3847/1538-4365/aa8992

Language: Unknown

Publisher: American Astronomical Society

Publication Date: 2017

detail.hit.zdb_id: 2006860-8

detail.hit.zdb_id: 2207650-5

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BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

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Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

Botta, Michela ; Tsonas, Anissa M ; Pillay, Janesh ; [et al.]

Elsevier BV ; 2021

In: The Lancet Respiratory Medicine Vol. 9, No. 2 ( 2021-02), p. 139-148

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In: The Lancet Respiratory Medicine, Elsevier BV, Vol. 9, No. 2 ( 2021-02), p. 139-148

Type of Medium: Online Resource

ISSN: 2213-2600

URL: Article

DOI: 10.1016/S2213-2600(20)30459-8

Language: English

Publisher: Elsevier BV

Publication Date: 2021

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Regulation of metabolic health by dietary histidine in mice

Flores, Victoria ; Spicer, Alexandra B. ; Sonsalla, Michelle M. ; [et al.]

Wiley ; 2023

In: The Journal of Physiology Vol. 601, No. 11 ( 2023-06), p. 2139-2163

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In: The Journal of Physiology, Wiley, Vol. 601, No. 11 ( 2023-06), p. 2139-2163

Abstract: Low‐protein (LP) diets are associated with a decreased risk of diabetes in humans, and promote leanness and glycaemic control in both rodents and humans. While the effects of an LP diet on glycaemic control are mediated by reduced levels of the branched‐chain amino acids, we have observed that reducing dietary levels of the other six essential amino acids leads to changes in body composition. Here, we find that dietary histidine plays a key role in the response to an LP diet in male C57BL/6J mice. Specifically reducing dietary levels of histidine by 67% reduces the weight gain of young, lean male mice, reducing both adipose and lean mass without altering glucose metabolism, and rapidly reverses diet‐induced obesity and hepatic steatosis in diet‐induced obese male mice, increasing insulin sensitivity. This normalization of metabolic health was associated not with caloric restriction or increased activity, but with increased energy expenditure. Surprisingly, the effects of histidine restriction do not require the energy balance hormone Fgf21 . Histidine restriction that was started in midlife promoted leanness and glucose tolerance in aged males but not females, but did not affect frailty or lifespan in either sex. Finally, we demonstrate that variation in dietary histidine levels helps to explain body mass index differences in humans. Overall, our findings demonstrate that dietary histidine is a key regulator of weight and body composition in male mice and in humans, and suggest that reducing dietary histidine may be a translatable option for the treatment of obesity. image Key points Protein restriction (PR) promotes metabolic health in rodents and humans and extends rodent lifespan. Restriction of specific individual essential amino acids can recapitulate the benefits of PR. Reduced histidine promotes leanness and increased energy expenditure in male mice. Reduced histidine does not extend the lifespan of mice when begun in midlife. Dietary levels of histidine are positively associated with body mass index in humans.

Type of Medium: Online Resource

ISSN: 0022-3751 , 1469-7793

URL: Issue

URL: Article

DOI: 10.1113/tjp.v601.11

DOI: 10.1113/JP283261

RVK:

WA 15000

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 1475290-6

SSG: 12

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FH Potsdam

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Prevalence of gambling problems, help-seeking, and relationships with trauma in veterans

Metcalf, Olivia ; Lawrence-Wood, Ellie ; Baur, Jenelle ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 5 ( 2022-5-25), p. e0268346-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 5 ( 2022-5-25), p. e0268346-

Abstract: Veterans who have recently left the military (i.e., transitioned) may be vulnerable to the development of psychiatric disorders, but little is known about gambling problems in this population. This study investigated the prevalence and risk factors of gambling problems, help-seeking amongst veterans with gambling problems, and relationships with trauma and posttraumatic psychopathology. Methods Cross-sectional self-report survey data from 3,511 Australian Defence Force members who left the military within the past five years. Surveys included measures of gambling problems (PGSI); depressive symptoms (PHQ-9); posttraumatic stress disorder (PCL-5); help-seeking behaviours; military and non-military-related trauma. Results Prevalence rates for problem gambling (PGSI ≥ 5) were 4.6%, while an additional 8.8% were classified in terms of at-risk gambling (PGSI = 1–4). Time since leaving the military was not associated with gambling problems. Only 2.1% of veterans with problem gambling reported help-seeking for their gambling. While trauma exposure, depression, and Posttraumatic Stress Disorder (PTSD) were all related to gambling problems at the bivariate level, only arousal and dysphoric-related affect were uniquely associated with gambling problems when adjusting for covariates. Discussion Gambling problems may be under-recognised relative to other psychiatric issues. Posttraumatic mental health problems, rather than trauma exposure per se, may explain the relationship between trauma and gambling problems. Conclusions Some veterans are in a period of vulnerability during transition out of military service, and harms associated with gambling problems may be exacerbated during this period.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0268346

DOI: 10.1371/journal.pone.0268346.t001

DOI: 10.1371/journal.pone.0268346.t002

DOI: 10.1371/journal.pone.0268346.t003

DOI: 10.1371/journal.pone.0268346.t004

DOI: 10.1371/journal.pone.0268346.t005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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FH Potsdam

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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

Yu, Deyang ; Richardson, Nicole E. ; Green, Cara L. ; [et al.]

Elsevier BV ; 2021

In: Cell Metabolism Vol. 33, No. 5 ( 2021-05), p. 905-922.e6

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In: Cell Metabolism, Elsevier BV, Vol. 33, No. 5 ( 2021-05), p. 905-922.e6

Type of Medium: Online Resource

ISSN: 1550-4131

URL: Article

DOI: 10.1016/j.cmet.2021.03.025

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2174469-5

SSG: 12

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FH Potsdam

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Effect of nusinersen on motor, respiratory and bulbar function in early-onset spinal muscular atrophy

Pechmann, Astrid ; Behrens, Max ; Dörnbrack, Katharina ; [et al.]

Oxford University Press (OUP) ; 2023

In: Brain Vol. 146, No. 2 ( 2023-02-13), p. 668-677

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In: Brain, Oxford University Press (OUP), Vol. 146, No. 2 ( 2023-02-13), p. 668-677

Abstract: 5q-associated spinal muscular atrophy is a rare neuromuscular disorder with the leading symptom of a proximal muscle weakness. Three different drugs have been approved by the European Medicines Agency and Food and Drug Administration for the treatment of spinal muscular atrophy patients, however, long-term experience is still scarce. In contrast to clinical trial data with restricted patient populations and short observation periods, we report here real-world evidence on a broad spectrum of patients with early-onset spinal muscular atrophy treated with nusinersen focusing on effects regarding motor milestones, and respiratory and bulbar insufficiency during the first years of treatment. Within the SMArtCARE registry, all patients under treatment with nusinersen who never had the ability to sit independently before the start of treatment were identified for data analysis. The primary outcome of this analysis was the change in motor function evaluated with the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders and motor milestones considering World Health Organization criteria. Further, we evaluated data on the need for ventilator support and tube feeding, and mortality. In total, 143 patients with early-onset spinal muscular atrophy were included in the data analysis with a follow-up period of up to 38 months. We observed major improvements in motor function evaluated with the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders. Improvements were greater in children & gt;2 years of age at start of treatment than in older children. 24.5% of children gained the ability to sit independently. Major improvements were observed during the first 14 months of treatment. The need for intermittent ventilator support and tube feeding increased despite treatment with nusinersen. Our findings confirm the increasing real-world evidence that treatment with nusinersen has a dramatic influence on disease progression and survival in patients with early-onset spinal muscular atrophy. Major improvements in motor function are seen in children younger than 2 years at the start of treatment. Bulbar and respiratory function needs to be closely monitored, as these functions do not improve equivalent to motor function.

Type of Medium: Online Resource

ISSN: 0006-8950 , 1460-2156

URL: Article

DOI: 10.1093/brain/awac252

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2023

detail.hit.zdb_id: 1474117-9

SSG: 12

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Wissenschaftspark Albert Einstein

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FH Potsdam

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Gambling problems predict suicidality in recently transitioned military veterans

Metcalf, Olivia ; Roebuck, Greg ; Lawrence-Wood, Ellie ; [et al.]

Elsevier BV ; 2023

In: Australian and New Zealand Journal of Public Health Vol. 47, No. 3 ( 2023-06), p. 100038-

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In: Australian and New Zealand Journal of Public Health, Elsevier BV, Vol. 47, No. 3 ( 2023-06), p. 100038-

Type of Medium: Online Resource

ISSN: 1326-0200

URL: Article

DOI: 10.1016/j.anzjph.2023.100038

Language: English

Publisher: Elsevier BV

Publication Date: 2023

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