In:
Hormone and Metabolic Research, Georg Thieme Verlag KG, Vol. 55, No. 05 ( 2023-05), p. 323-332
Abstract:
Histologically aggressive micropapillary thyroid carcinomas (PTMC) subtypes are
thought to be associated with an aggressive clinical course. However, evidence for unfavorable clinical outcomes in patients with aggressive PTMC subtypes is
not clear. In this study, we intended to determine the difference in clinical outcomes between patients with aggressive and non-aggressive PTMC subtypes. In
this multicenter cohort study, the computer-recorded clinical and histopathological data of patients who underwent thyroid surgery between January
2000 - January 2021 in 9 referral centers and were diagnosed as PTMC were analyzed. A total of 1585 patients [female 1340 (84.5%), male 245
(15.5%), mean age 47.9±11.63 years), with a mean follow-up time of 66.55±37.16 months], were included in the study. Ninety-eight cases were diagnosed as aggressive and 1487 as non-aggressive subtypes.
Persistent/recurrent disease was observed in 33 (33.7% )and 41 (2.8%) patients with aggressive and non-aggressive subtypes
(p 〈 0.001). Diseases-free survival rates were markedly lower in patients
with aggressive than in those with non-aggressive PTMC subtypes (66.3 vs. 94.8%, log-rank p 〈 0.001). Moreover, in multivariate analysis,
aggressive histology was an independent predictor of persistent/recurrent disease, after controlling for other contributing
factors (HR 5.78, 95% CI 3.32–10, p 〈 0.001). Patients
with aggressive PTMC subtypes had higher rates of incomplete biochemical and structural response than patients with non-aggressive subtypes as well
(p 〈 0.001). Aggressive PTMC subtypes share many characteristics with
histologically identical tumors 〉 1 cm in size. Therefore, the
histopathological subtype of PTMC should be taken into consideration to tailor a personalized management plan.
Type of Medium:
Online Resource
ISSN:
0018-5043
,
1439-4286
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2023
detail.hit.zdb_id:
2056576-8
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