In:
Science, American Association for the Advancement of Science (AAAS), Vol. 261, No. 5117 ( 1993-07-02), p. 86-90
Abstract:
Type I diabetes [insulin-dependent diabetes mellitus (IDDM)] is an autoimmune disease associated with the destruction of pancreatic β cells. Serum from patients with IDDM increased L-type calcium channel activity of insulin-producing cells and of GH 3 cells derived from a pituitary tumor. The subsequent increase in the concentration of free cytoplasmic Ca 2+ ([Ca 2+ ] i ) was associated with DNA fragmentation typical of programmed cell death or apoptosis. These effects of the serum were prevented by adding a blocker of voltage-activated L-type Ca 2+ channels. When the serum was depleted of immunoglobulin M (IgM), it no longer affected [Ca 2+ ] i . An IgM-mediated increase in Ca 2+ influx may thus be part of the autoimmune reaction associated with IDDM and contribute to the destruction of β cells in vivo.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.7686306
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
1993
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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