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  • 1
    Online Resource
    Online Resource
    American Veterinary Medical Association (AVMA) ; 2002
    In:  American Journal of Veterinary Research Vol. 63, No. 6 ( 2002-06-01), p. 874-879
    In: American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 63, No. 6 ( 2002-06-01), p. 874-879
    Abstract: Objective —To examine cross-reactivity of aeroallergens in Colorado and surrounding states by evaluating concurrent positive reactions of related and nonrelated allergens of intradermal tests in dogs. Sample Population —Intradermal test results of 268 atopic dogs. Procedure —A retrospective evaluation of skin test results for 268 dogs was performed. Pairs of closely related and nonrelated allergens were evaluated. Group 1 consisted of closely related allergens with demonstrated antibody cross-reactivity in humans. In group 2, allergens of the same plant group (ie, trees, grasses, or weeds) that were not closely related were paired. In group 3, allergen pairs were of different plant groups. Plant allergens were paired with dust mite allergens, animal dander, or mold spores in group 4. In the last group, allergens not derived from plants were paired. Data were evaluated twice by use of a different definition of a positive reaction. Significance of the difference between group means of log odds ratios was estimated by use of a bootstrap percentile confidence interval. Results —Significant differences in the number of concurrent positive reactions were not found between related versus nonrelated grass, weed, or tree allergens. Significant differences in the number of concurrent positive reactions were found between plant allergens of different groups (ie, grasses, weeds, and trees) and plant allergens of the same groups, related or nonrelated , as well as between plant-derived and nonplant-derived allergens. Many dogs reacting to a specific allergen did not react to a closely related allergen at the same time. Conclusion and Clinical Relevance —These results provide evidence against clinically relevant cross-reactivity and suggest that allergen-specific immunotherapy should be formulated on the basis of single allergen test results. ( Am J Vet Res 2002;63:874–879)
    Type of Medium: Online Resource
    ISSN: 0002-9645
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2002
    detail.hit.zdb_id: 2056942-7
    SSG: 22
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  • 2
    Online Resource
    Online Resource
    American Veterinary Medical Association (AVMA) ; 2002
    In:  American Journal of Veterinary Research Vol. 63, No. 4 ( 2002-04-01), p. 491-494
    In: American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 63, No. 4 ( 2002-04-01), p. 491-494
    Abstract: Objective —To evaluate the effect of long-term treatment with tetracycline and niacinamide on antibody production in dogs by measuring postvaccinal serum concentrations of antibodies against canine parvovirus and canine distemper virus. Animals —10 dogs receiving long-term treatment with tetracycline and niacinamide (treatment group) and 10 healthy dogs (control group). Procedure —The treatment group included 9 dogs with discoid lupus erythematosus and 1 dog with pemphigus foliaceus on long-term treatment ( 〉 12 months) with tetracycline and niacinamide. The control group included 10 healthy dogs with no clinical signs of disease and no administered medications for the past 3 months. Blood samples were obtained from all dogs by jugular venipuncture. Serum antibody titers against canine parvovirus and canine distemper virus antigens were measured, using hemaglutination inhibition and serum neutralization, respectively, and compared between groups. Results —A significant difference in antibody titers between treatment- and control-group dogs was not found. All dogs had protective antibody titers against canine distemper virus, and 8 of 10 dogs from each group had protective titers against canine parvovirus infection. Conclusion and Clinical Relevance —These results provide evidence that long-term treatment with tetracycline and niacinamide does not interfere with routine vaccinations and thus does not seem to influence antibody production in dogs. ( Am J Vet Res 2002; 63:491–494)
    Type of Medium: Online Resource
    ISSN: 0002-9645
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2002
    detail.hit.zdb_id: 2056942-7
    SSG: 22
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  • 3
    Online Resource
    Online Resource
    Wiley ; 2008
    In:  Veterinary Dermatology Vol. 19, No. 4 ( 2008-08), p. 199-208
    In: Veterinary Dermatology, Wiley, Vol. 19, No. 4 ( 2008-08), p. 199-208
    Abstract: Although ketoconazole has been used extensively in dogs for the treatment of various fungal infections, information about adverse effects is mainly anecdotal. Common adverse effects in humans include dose‐dependant anorexia, nausea and vomiting, allergic rashes and pruritus. Drug‐induced hepatitis is very rare, but potentially fatal. The aim of this study was to evaluate the type and frequency of adverse effects associated with ketoconazole therapy in dogs treated for skin diseases and any possible influence of dosage, duration of therapy, signalment or concurrent medication. The medical records of 632 dogs treated with ketoconazole (2.6–33.4 mg/kg) were reviewed. Adverse effects occurred in 14.6% (92 dogs) and included vomiting (7.1%), anorexia (4.9%), lethargy (1.9%), diarrhea (1.1%), pruritus (0.6%), erythema (0.3%) and other adverse effects (2.5%). Of the dogs with other adverse effects, four of 16 (25%) were ataxic and three of these received concurrent ivermectin. Adverse effects were significantly more often recorded in dogs concurrently treated with ciclosporin ( P =  0.034) or ivermectin ( P =  0.007). Increased liver enzyme levels were reported rarely, and icterus was not seen in any of the dogs. However, monitoring liver enzymes during therapy is recommended, although this might not necessarily prevent severe idiosyncratic hepatotoxicity.
    Type of Medium: Online Resource
    ISSN: 0959-4493 , 1365-3164
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2011122-8
    SSG: 22
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  • 4
    Online Resource
    Online Resource
    Wiley ; 1991
    In:  Veterinary Dermatology Vol. 2, No. 3-4 ( 1991-09), p. 119-123
    In: Veterinary Dermatology, Wiley, Vol. 2, No. 3-4 ( 1991-09), p. 119-123
    Abstract: Abstract— The purpose of this study was to evaluate the effect of intravenously administered tiletamine‐zolazepam on the response of cats to intradermal injections of varying concentrations of histamine, thereby giving an indication of the feasibility of using tiletamine‐zolazepam for the restraint of cats during intradermal skin testing. Ten cats were injected intradermally with increasing concentrations of histamine and a negative control before and after anesthesia with tiletamine‐zolazepam (5 mg.kg ‐1 intravenously). The wheals produced by the eight different concentrations of histamine (1:100,000 to 1:9,600,000) and the negative control before and after anesthesia were compared in each cat. There was no significant difference in the response to the intradermal histamine injections before and after anesthesia. It was concluded that 4 mg.kg ‐1 of tiletaminezolazepame administered intravenously may be a good anesthetic choice for intradermal skin testing in cats. Résumé— Le but de cette étude était d'évaluer l'influence d'une injection intraveineuse de tilétamine‐zolazepam sur la réponse de chats à des injections intradermiques de différentes concentration d'histamine, afin de savoir si une une anesthésie à l'aide de tilétamine‐zolazepam était utilisable pour faire des tests cutanés chez le chat. Des concentrations croissantes d'histamine et un témoin négative ont été injectés par voie intradermique à dix chats avant et après injection IV de tilétamine‐zolazepam (5 mg/kg). Le diamètre des papules aux neufs concentrations différentes d'histamine (1:100 000, 1:2 800 000, 1:4 800 000 et 1:9 600 000) et au témoin négatif ont été comparés pour chaque chat avant et après aesthésie. Il n'existait de différence significative avant et après anesthésie. Il a été conclu qu'une anesthésie à l'aide de 5 mg IV de tilétamine‐zolazepam était utilisable pour effectuer des intradermoréactions chez le chat. Zusammenfassung— Ziel dieser Studie war die Austwertung der Wirkung von intravenös verabreichtem Tiletamin‐Zolazepam auf die Reaktion von Katzen gegenüber intradermal injiziertem Histamin unter‐schiedlicher Konzentrationen. So ergeben sich Hinweise auf die Eignung von Tiletamin‐Zolazepan für die Ruhigstellung von Katzen bei intradermalen Hauttests. Bei zehn Katzen wurde Histamin in steigenden konzentrationen zusammen mit einer Negativkontrolle intradermal vor und nach Anästhesie mit Tiletamin‐Zolazepam (5 mg/kg intravenös) injiziert. Bei jeder Katze wurden die Negativkontrollen und die lokalen Schwellungen durch die neun verschiedenen Histaminkonzentrationen (1:100,000–1:9,600,000) vor und nach der Anästhesic verglichen. Es ergaben sich keine signifikanten Unterschiedge in den Reaktionen auf intradermale Histamininjektionen vor und nach der Anästhesie. Daraus läßt sich schlußfolgern, daß 5 mg Tiletamin‐Zolazepam, intravenös verabreicht, eine gute Anästhesiemöglichkeit für Hauttests bei Katzen darstellen. Resumen  El presente reportaje tiene como objetivo el estudio de la administración intravenosa de tiletamina‐zolazepám en la respuesta de un grupo de gatos sometidos a la inyección intradérmica de diferentes concentraciones de histamina, dando asi una indicación de la utilidad de tiletamina‐zolezopan para la inmobilización de gatos durante el test de la inyección intrdérmica. Se inyectaron intradermicamente diez gatos con concentraciones crecientes de histamina y un control negativo, antes y después de la anestesia producida con tiletamina‐zolazepám (5 mg/kg dé forma intravenosa). Luego se comparon las ronchas producidas por las diferentes concentraciones de histamina (1:100,000–1:9,600,000) y el control negativo, antes y después de la anestesia. No hubo diferencia significativa en la respuesta a la inyección intradérmica de histamina antes o después de la anestesia. Así, se concluyó que la administración de 5 mg de tiletamina‐zolazepám de forma intravenosa podría ser un anestético satisfactorio en el test intradérmico llevado a cabo en gatos.
    Type of Medium: Online Resource
    ISSN: 0959-4493 , 1365-3164
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 1991
    detail.hit.zdb_id: 2011122-8
    SSG: 22
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  • 5
    Online Resource
    Online Resource
    Wiley ; 2008
    In:  Veterinary Dermatology Vol. 19, No. 2 ( 2008-04), p. 88-94
    In: Veterinary Dermatology, Wiley, Vol. 19, No. 2 ( 2008-04), p. 88-94
    Abstract: This study reports the condition onychomadesis affecting multiple claws in Norwegian Gordon and English setters. Medical records of and claw biopsies from 18 Gordon and four English setters with onychomadesis of multiple claws were obtained from July 2005 to January 2007. Only dogs with symmetrical onychomadesis and no signs of concurrent disease were included. Histopathological features varied between dogs, but typically included interface dermatitis with subepidermal cleft formation, pigment incontinence, basal cell vacuolization and necrosis, spongiosis and lymphocytic exocytosis, a lymphocytic, plasmacytic subepidermal inflammation, and fibroplasia. In two dogs, histopathological signs of a superficial infection were present. The age of onset of disease varied between 2 and 7 years with a mean of 3.9 years, and was not correlated with vaccination time. Six of the affected dogs also had siblings with the disease. Due to the close relationship of the affected dogs, pedigree map analysis was not possible. Three dogs were euthanized because of the disease and two had regrowth of normal claws. Seventeen dogs had persistent onychodystrophy that typically was nonpainful during therapy which in most dogs consisted of fatty acid supplementation or prednisolone.
    Type of Medium: Online Resource
    ISSN: 0959-4493 , 1365-3164
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2011122-8
    SSG: 22
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  • 6
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2019
    In:  Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere Vol. 47, No. 05 ( 2019-10), p. 1-8
    In: Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Georg Thieme Verlag KG, Vol. 47, No. 05 ( 2019-10), p. 1-8
    Abstract: Mucous membrane pemphigoid was diagnosed in a 2.5-year-old male intact foxhound-beagle cross which was presented with an acute onset of non-pruritic, multifocal, slowly progressive erosive-ulcerative dermatitis predominantly affecting the nasal planum, eyelids and muzzle with multiple vesicles on the inner pinnae, oral mucosa and tongue. The diagnosis was based on clinical signs and histological examination of skin biopsies. The patient did not respond to immunosuppressive prednisolone therapy, but went into complete remission with oral doxycycline and niacinamide and stayed in remission on long-term exclusive niacinamide treatment.
    Type of Medium: Online Resource
    ISSN: 1434-1239 , 2567-5842
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    SSG: 22
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  • 7
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2019
    In:  Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere Vol. 47, No. 05 ( 2019-10), p. 365-372
    In: Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Georg Thieme Verlag KG, Vol. 47, No. 05 ( 2019-10), p. 365-372
    Abstract: Bei einem 2,5-jährigen, männlich-intakten Foxhound-Beagle-Mischling mit akuter, multifokaler, langsam fortschreitender, erosiv-ulzerierender Dermatitis ohne Juckreiz wurde basierend auf klinischen Symptomen und histologischer Untersuchung von Hautbioptaten ein mukokutanes Pemphigoid diagnostiziert. Betroffen waren Nasenspiegel, Augenlider und Schnauze. Bläschen fanden sich auch an Ohreninnenseiten, Maulschleimhaut und Zunge. Der Patient sprach nicht auf eine immunsuppressive Therapie mit Prednisolon an. Mit oraler Gabe von Doxycyclin und Niacinamid ließ sich eine vollständige Remission erreichen und die Erkrankung blieb unter langfristiger ausschließlicher Therapie mit Niacinamid in Remission.
    Type of Medium: Online Resource
    ISSN: 1434-1239 , 2567-5842
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    SSG: 22
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  • 8
    Online Resource
    Online Resource
    American Veterinary Medical Association (AVMA) ; 2001
    In:  American Journal of Veterinary Research Vol. 62, No. 3 ( 2001-03-01), p. 307-310
    In: American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 62, No. 3 ( 2001-03-01), p. 307-310
    Abstract: Objective —To evaluate the safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis. Animals —30 dogs with atopic dermatitis examined at a veterinary dermatology referral practice for treatment with allergen-specific immunotherapy. Procedure —A catheter was placed in a vein in each dog. Dogs were constantly observed throughout the procedure. Allergen extracts were administered in increasing concentrations every 30 minutes for 6 hours to a maintenance concentration of 20,000 protein nitrogen units/ml. Epinephrine, oxygen, and emergency treatment were available as needed. Results —In 22 (73%) dogs, rush immunotherapy safely replaced the prolonged induction period (15 weeks) of weekly injections that consists of increasing concentrations of allergen extract. In 7 (23%) dogs, the induction period was abbreviated to 4 weeks. Of the 8 dogs that developed problems during rush immunotherapy, increased pruritus necessitated premature cessation of rush immunotherapy in 7, and 1 developed generalized wheals. Oral administration of prednisolone (1 mg/kg of body weight) resulted in resolution of adverse effects in all 8 dogs. Conclusion and Clinical Relevance —Rush immunotherapy performed by personnel at a veterinary hospital is a safe method for treatment of dogs with atopic dermatitis. ( Am J Vet Res 2001;62:307–310)
    Type of Medium: Online Resource
    ISSN: 0002-9645
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2001
    detail.hit.zdb_id: 2056942-7
    SSG: 22
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