In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 62, No. 9 ( 2001-09-01), p. 1428-1435
Abstract:
Objective —To determine cardiopulmonary effects of
total IV anesthesia with propofol and medetomidine in ponies and effect of atipamezole on recovery. Animals —10 ponies. Procedure —After sedation was induced by IV administration
of medetomidine (7 μg/kg of body weight), anesthesia was induced by IV administration of propofol
(2 mg/kg) and maintained for 4 hours with infusions of medetomidine (3.5 μg/kg per hour) and propofol
(0.07 to 0.11 mg/kg per minute). Spontaneous respiration was supplemented with oxygen. Cardiopulmonary
measurements and blood concentrations of propofol were determined during anesthesia. Five ponies
received atipamezole (60 μg/kg) during recovery. Results —During anesthesia, mean cardiac index and
heart rate increased significantly until 150 minutes, then decreased until cessation of anesthesia. Mean
arterial pressure and systemic vascular resistance index increased significantly between 150 minutes
and 4 hours. In 4 ponies, PaO 2 decreased to 〈 60 mm
Hg. Mean blood propofol concentrations from 20 minutes after induction onwards ranged from 2.3 to 3.5
μg/ml. Recoveries were without complications and were complete within 28 minutes with atipamezole
administration and 39 minutes without atipamezole administration. Conclusions and Clinical Relevance —During total IV
anesthesia of long duration with medetomidine-propofol, cardiovascular function is comparable to or better
than under inhalation anesthesia. This technique may prove suitable in equids in which prompt recovery is
essential; however, in some animals severe hypoxia may develop and oxygen supplementation may be
necessary. ( Am J Vet Res 2001;62:1428–1435)
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2001.62.1428
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2001
detail.hit.zdb_id:
2056942-7
SSG:
22
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