In:
European Heart Journal. Acute Cardiovascular Care, Oxford University Press (OUP), Vol. 11, No. 11 ( 2022-11-30), p. 826-833
Abstract:
To validate correlations between contrast-enhanced magnetic resonance imaging (CE-MRI) infarct mass and high-sensitivity cardiac Troponin T (hs-cTnT) values at different time points in patients with confirmed acute myocardial infarction (AMI). Methods and results Patients presenting with AMI and with available CE-MRI between 1 January 2018 and 31 December 2020 were included. Correlation coefficients between hs-cTnT on admission, after 24, 48, 72, and 96 h, and peak hs-cTnT values and CE-MRI infarct mass were calculated. Correlations between hs-cTnT and CE-MRI infarct mass were compared with those of a third generation cTnT assay from a previously published study of our group. A total of 137 patients were included for the present analysis. Median CE-MRI infarct mass was 12,5 g [95% confidence interval (CI): 9.8–16.2 g]. Hs-cTnT values and infarct mass correlated well at all time points including admission (r = 0.474, 95% CI: 0.331–0.560, P & lt; 0.0001), 24 h (r = 0.508, 95% CI: 0.370–0.625, P & lt; 0.0001), 48 h (r = 0.547, 95% CI: 0.404–0.664, P & lt; 0.0001), 72 h (r = 0.489, 95% CI: 0.320–0.628, P & lt; 0.0001), 96 h (r = 0.509, 95% CI: 0.330–0.653, P & lt; 0.001) including peak hs-cTnT values (r = 0.547, 95% CI: 0.416–0.656, P & lt; 0.0001), and maximum absolute delta changes within 96 h (r = 0.507, 95% CI: 0.369–0.622, P & lt; 0.001). Correlations of the third generation assay could be confirmed for hs-cTnT at all time points. A superior correlation with CE-MRI infarct mass was observed for hs-cTnT values on admission. Conclusion Hs-cTnT values at different time points correlate well with CE-MRI infarct mass. Correlations of admission hs-cTnT values are superior to those of a third generation assay.
Type of Medium:
Online Resource
ISSN:
2048-8726
,
2048-8734
DOI:
10.1093/ehjacc/zuac122
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2022
detail.hit.zdb_id:
2663340-1
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