In:
Hormone Research in Paediatrics, S. Karger AG, Vol. 66, No. 5 ( 2006), p. 211-215
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 While numerous studies have examined 25(OH)-vitamin D 〈 sub 〉 3 〈 /sub 〉 (25-D) concentrations and their relation to parathyroid hormone (PTH) levels there is only limited information on the interrelation between 25-D, 1,25(OH) 〈 sub 〉 2 〈 /sub 〉 -vitamin D 〈 sub 〉 3 〈 /sub 〉 (1,25-D) and PTH. It was the aim of this study to assess the vitamin D endocrine system and its relation to age and body mass index (BMI). 〈 i 〉 Methods: 〈 /i 〉 This cross-sectional study comprised a convenience sample of 483 adults which attended the endocrinology outpatient service of a university hospital in the years 2002–2004. 〈 i 〉 Results: 〈 /i 〉 The mean concentrations of 25-D, 1,25-D, calcium and PTH were 21.0 ± 10.6 ng/ml, 47.9 ± 21.7 pg/ml, 9.48 ± 0.48 mg/dl and 51.0 ± 27.2 pg/ml, respectively. 25-D was related (p 〈 0.01) to BMI, age, PTH and 1,25-D. After correction for 25-D, we found no relation between BMI and 1,25-D. PTH was related (p 〈 0.01) to serum calcium, BMI, age and 1,25-D (p = 0015). There was a seasonal variation in both, 25-D and 1,25-D serum concentrations: 25-D levels were lowest in January and increased until July while the nadir and zenith of 1,25-D were found in April and October, respectively. 〈 i 〉 Conclusion: 〈 /i 〉 Since BMI was negatively related to 25-D the prevalence of 25-D deficiency ( 〈 8.8 ng/ml) increased from 8.8% in subjects with BMI 〈 30 kg/m 〈 sup 〉 2 〈 /sup 〉 to 15.0% in subjects with BMI 〉 30 kg/m 〈 sup 〉 2 〈 /sup 〉 . BMI, age and season should be taken into account when assessing a patients vitamin D status and more aggressive vitamin D supplementation should be considered for obese subjects.
Type of Medium:
Online Resource
ISSN:
1663-2818
,
1663-2826
Language:
English
Publisher:
S. Karger AG
Publication Date:
2006
detail.hit.zdb_id:
2540224-9
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