In:
Frontiers in Immunology, Frontiers Media SA, Vol. 14 ( 2023-7-14)
Abstract:
The Coronavirus Disease 2019 (COVID-19) is mainly a respiratory syndrome that can affect multiple organ systems, causing a variety of symptoms. Among the most common and characteristic symptoms are deficits in smell and taste perception, which may last for weeks/months after COVID-19 diagnosis owing to mechanisms that are not fully elucidated. Methods In order to identify the determinants of olfactory symptom persistence, we obtained olfactory mucosa (OM) from 21 subjects, grouped according to clinical criteria: i) with persistent olfactory symptoms; ii) with transient olfactory symptoms; iii) without olfactory symptoms; and iv) non-COVID-19 controls. Cells from the olfactory mucosa were harvested for transcriptome analyses. Results and discussion RNA-Seq assays showed that gene expression levels are altered for a long time after infection. The expression profile of micro RNAs appeared significantly altered after infection, but no relationship with olfactory symptoms was found. On the other hand, patients with persistent olfactory deficits displayed increased levels of expression of genes involved in the inflammatory response and zinc homeostasis, suggesting an association with persistent or transient olfactory deficits in individuals who experienced SARS-CoV-2 infection.
Type of Medium:
Online Resource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2023.1148595
DOI:
10.3389/fimmu.2023.1148595.s001
DOI:
10.3389/fimmu.2023.1148595.s002
DOI:
10.3389/fimmu.2023.1148595.s003
DOI:
10.3389/fimmu.2023.1148595.s004
DOI:
10.3389/fimmu.2023.1148595.s005
DOI:
10.3389/fimmu.2023.1148595.s006
DOI:
10.3389/fimmu.2023.1148595.s007
DOI:
10.3389/fimmu.2023.1148595.s008
DOI:
10.3389/fimmu.2023.1148595.s009
DOI:
10.3389/fimmu.2023.1148595.s010
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2606827-8
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