In:
Scandinavian Journal of Haematology, Wiley, Vol. 37, No. 5 ( 1986-11), p. 429-437
Abstract:
Suramin was used to analyze the growth‐effects of blockade of iron uptake on two established human cell lines, U‐937 (monocytoid) and K‐562 (erythroleukemic). Suramin suppressed cell surface transferrin (Tf) binding and uptake of iron via inhibition of receptor‐mediated endocytosis (RME). As a result, both lines accumulated in the S‐phase. DNA synthesis and cell division were inhibited in the suramin‐treated U‐937, but not in K‐562. Iron, supplied by a route alternative to Tf ‐ to suramin‐suppressed U‐937 cells, reinitiated DNA synthesis and cell division, although at a lower level than in control cells. Multiple effects on iron‐dependent enzymes and an inhibition of binding of undefined growth factors necessary for the transition through the cell cycle are suggested to be mechanisms by which suramin affects the U‐937 cells. The results imply that clinically observed side effects of suramin may be caused by interference with cellular iron metabolism.
Type of Medium:
Online Resource
ISSN:
0036-553X
DOI:
10.1111/ejh.1986.37.issue-5
DOI:
10.1111/j.1600-0609.1986.tb02633.x
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
2027114-1
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