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Correction to “Observations of ozone and related species in the northeast Pacific during the PHOBEA campaigns: 2. Airborne observations” by Robert A. Kotchenruther et al.

Kotchenruther, Robert A. ; Jaffe, Daniel A. ; Beine, Harald J. ; [et al.]

American Geophysical Union (AGU) ; 2001

In: Journal of Geophysical Research: Atmospheres Vol. 106, No. D17 ( 2001-09-16), p. 20507-20508

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In: Journal of Geophysical Research: Atmospheres, American Geophysical Union (AGU), Vol. 106, No. D17 ( 2001-09-16), p. 20507-20508

Type of Medium: Online Resource

ISSN: 0148-0227

URL: Article

DOI: 10.1029/2001JD000962

Language: English

Publisher: American Geophysical Union (AGU)

Publication Date: 2001

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detail.hit.zdb_id: 3094104-0

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detail.hit.zdb_id: 2016813-5

detail.hit.zdb_id: 2016810-X

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detail.hit.zdb_id: 2016800-7

detail.hit.zdb_id: 161666-3

detail.hit.zdb_id: 161667-5

detail.hit.zdb_id: 2969341-X

detail.hit.zdb_id: 161665-1

detail.hit.zdb_id: 3094268-8

detail.hit.zdb_id: 710256-2

detail.hit.zdb_id: 2016804-4

detail.hit.zdb_id: 3094181-7

detail.hit.zdb_id: 3094219-6

detail.hit.zdb_id: 3094167-2

detail.hit.zdb_id: 2220777-6

detail.hit.zdb_id: 3094197-0

SSG: 16,13

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Clinical Outcomes and Bacterial Characteristics of Carbapenem-Resistant Acinetobacter baumannii Among Patients from Different Global Regions

Wang, Minggui ; Ge, Lizhao ; Chen, Liang ; [et al.]

Oxford University Press (OUP) ; 2023

In: Clinical Infectious Diseases ( 2023-09-20)

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In: Clinical Infectious Diseases, Oxford University Press (OUP), ( 2023-09-20)

Abstract: Carbapenem-resistant Acinetobacter baumannii (CRAb) is one of the most problematic antimicrobial-resistant bacteria. We sought to elucidate the international epidemiology and clinical impact of CRAb. Methods In a prospective observational cohort study, 842 hospitalized patients with a clinical CRAb culture were enrolled at 46 hospitals in five global regions between 2017 and 2019. The primary outcome was all-cause mortality at 30 days from the index culture. The strains underwent whole-genome analysis. Results Of 842 cases, 536 (64%) represented infection. By 30 days, 128 (24%) of the infected patients died, ranging from 1 (6%) of 18 in Australia-Singapore to 54 (25%) of 216 in the United States and 24 (49%) of 49 in South-Central America, whereas 42 (14%) of non-infected patients died. Bacteremia was associated with a higher risk of death compared with other types of infection (40 [42%] of 96 vs. 88 [20%] of 440). In a multivariable logistic regression analysis, bloodstream infection and higher age-adjusted Charlson comorbidity index were independently associated with 30-day mortality. Clonal group 2 (CG2) strains predominated except in South-Central America, ranging from 216 (59%) of 369 in the United States to 282 (97%) of 291 in China. Acquired carbapenemase genes were carried by 769 (91%) of the 842 isolates. CG2 strains were significantly associated with higher levels of meropenem resistance, yet non-CG2 cases were over-represented among the deaths compared with CG2 cases. Conclusions CRAb infection types and clinical outcomes differed significantly across regions. While CG2 strains remained predominant, non-CG2 strains were associated with higher mortality. ClinicalTrials.gov #NCT03646227

Type of Medium: Online Resource

ISSN: 1058-4838 , 1537-6591

URL: Article

DOI: 10.1093/cid/ciad556

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2023

detail.hit.zdb_id: 2002229-3

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Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study

Wang, Minggui ; Earley, Michelle ; Chen, Liang ; [et al.]

Elsevier BV ; 2022

In: The Lancet Infectious Diseases Vol. 22, No. 3 ( 2022-03), p. 401-412

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In: The Lancet Infectious Diseases, Elsevier BV, Vol. 22, No. 3 ( 2022-03), p. 401-412

Type of Medium: Online Resource

ISSN: 1473-3099

URL: Article

DOI: 10.1016/S1473-3099(21)00399-6

Language: English

Publisher: Elsevier BV

Publication Date: 2022

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International Epidemiology of Carbapenemase-Producing Escherichia coli

Boutzoukas, Angelique E ; Komarow, Lauren ; Chen, Liang ; [et al.]

Oxford University Press (OUP) ; 2023

In: Clinical Infectious Diseases Vol. 77, No. 4 ( 2023-08-22), p. 499-509

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In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 77, No. 4 ( 2023-08-22), p. 499-509

Abstract: Carbapenemase-producing (CP) Escherichia coli (CP-Ec) are a global public health threat. We aimed to describe the clinical and molecular epidemiology and outcomes of patients from several countries with CP-Ec isolates obtained from a prospective cohort. Methods Patients with CP-Ec were enrolled from 26 hospitals in 6 countries. Clinical data were collected, and isolates underwent whole-genome sequencing. Clinical and molecular features and outcomes associated with isolates with or without metallo-β-lactamases (MBLs) were compared. The primary outcome was desirability of outcome ranking (DOOR) at 30 days after the index culture. Results Of the 114 CP-Ec isolates in Consortium on resistance against carbapenems in Klebsiella and other Enterobacterales-2 (CRACKLE-2), 49 harbored an MBL, most commonly blaNDM-5 (38/49, 78%). Strong regional variations were noted with MBL-Ec predominantly found among patients in China (23/49). Clinically, MBL-Ec were more often from urine sources (49% vs 29%), less often met criteria for infection (39% vs 58%, P = .04), and had lower acuity of illness when compared with non–MBL-Ec. Among patients with infection, the probability of a better DOOR outcome for a randomly selected patient with MBL-Ec as compared with non–MBL-Ec was 62% (95% CI: 48.2–74.3%). Among infected patients, non–MBL-Ec had increased 30-day (26% vs 0%; P = .02) and 90-day (39% vs 0%; P = .001) mortality compared with MBL-Ec. Conclusions Emergence of CP-Ec was observed with important geographic variations. Bacterial characteristics, clinical presentations, and outcomes differed between MBL-Ec and non–MBL-Ec. Mortality was higher among non-MBL isolates, which were more frequently isolated from blood, but these findings may be confounded by regional variations.

Type of Medium: Online Resource

ISSN: 1058-4838 , 1537-6591

URL: Article

DOI: 10.1093/cid/ciad288

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2023

detail.hit.zdb_id: 2002229-3

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Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti–Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema

Jampol, Lee M. ; Glassman, Adam R. ; Liu, Danni ; [et al.]

Elsevier BV ; 2018

In: Ophthalmology Vol. 125, No. 7 ( 2018-07), p. 1054-1063

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In: Ophthalmology, Elsevier BV, Vol. 125, No. 7 ( 2018-07), p. 1054-1063

Type of Medium: Online Resource

ISSN: 0161-6420

URL: Article

DOI: 10.1016/j.ophtha.2018.01.019

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2018

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The James Webb Space Telescope Mission

Gardner, Jonathan P. ; Mather, John C. ; Abbott, Randy ; [et al.]

IOP Publishing ; 2023

In: Publications of the Astronomical Society of the Pacific Vol. 135, No. 1048 ( 2023-06-01), p. 068001-

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In: Publications of the Astronomical Society of the Pacific, IOP Publishing, Vol. 135, No. 1048 ( 2023-06-01), p. 068001-

Abstract: Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4 m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5 m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 yr, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.

Type of Medium: Online Resource

ISSN: 0004-6280 , 1538-3873

URL: Article

DOI: 10.1088/1538-3873/acd1b5

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2023

detail.hit.zdb_id: 2003100-2

detail.hit.zdb_id: 2207655-4

SSG: 16,12

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Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study

Reyes, Jinnethe ; Komarow, Lauren ; Chen, Liang ; [et al.]

Elsevier BV ; 2023

In: The Lancet Microbe Vol. 4, No. 3 ( 2023-03), p. e159-e170

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In: The Lancet Microbe, Elsevier BV, Vol. 4, No. 3 ( 2023-03), p. e159-e170

Type of Medium: Online Resource

ISSN: 2666-5247

URL: Article

DOI: 10.1016/S2666-5247(22)00329-9

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 3028547-1

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, Daniel J ; Abdelmohsen, Kotb ; Abe, Akihisa ; [et al.]

Informa UK Limited ; 2016

In: Autophagy Vol. 12, No. 1 ( 2016-01-02), p. 1-222

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In: Autophagy, Informa UK Limited, Vol. 12, No. 1 ( 2016-01-02), p. 1-222

Type of Medium: Online Resource

ISSN: 1554-8627 , 1554-8635

URL: Article

DOI: 10.1080/15548627.2015.1100356

Language: English

Publisher: Informa UK Limited

Publication Date: 2016

detail.hit.zdb_id: 2262043-6

SSG: 12

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Characteristics of community-acquired carbapenem-resistant Enterobacterales

Shrestha, Rima ; Luterbach, Courtney L ; Dai, Weixiao ; [et al.]

Oxford University Press (OUP) ; 2022

In: Journal of Antimicrobial Chemotherapy Vol. 77, No. 10 ( 2022-09-30), p. 2763-2771

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In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 77, No. 10 ( 2022-09-30), p. 2763-2771

Abstract: Community-acquired carbapenem-resistant Enterobacterales (CA-CRE) are an important threat. Methods In CRACKLE-2, we defined patients with CA-CRE as admitted from home, without pre-existing conditions, and a positive culture within 48 h of admission. Healthcare-associated CRE (HA-CRE) were those with the lowest likelihood of community acquisition, not admitted from home and cultured & gt;48 h after admission. Specific genetic markers in carbapenemase-producing Klebsiella pneumoniae were evaluated through random forest modelling. Results CA-CRE and HA-CRE were detected in 83 (10%) and 208 (26%) of 807 patients. No significant differences were observed in bacterial species or strain type distribution. K. pneumoniae (204/291, 70%) was the most common CRE species, of these 184/204 (90%) were carbapenemase producers (CPKP). The top three genetic markers in random forest models were kpi_SA15, fimE, and kpfC. Of these, kpi_SA15 (which encodes a chaperone/usher system) was positively associated (OR 3.14, 95% CI 1.13–8.87, P = 0.026), and kpfC negatively associated (OR 0.21, 95% CI 0.05–0.72, P = 0.015) with CA-CPKP. Conclusions Ten percent of CDC-defined CRE were CA. The true proportion of CA-CRE in hospitalized patients is likely lower as patients may have had unrecorded prior healthcare exposure. The kpi_SA15 operon was associated with the CA phenotype.

Type of Medium: Online Resource

ISSN: 0305-7453 , 1460-2091

URL: Article

DOI: 10.1093/jac/dkac239

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2022

detail.hit.zdb_id: 1467478-6

SSG: 15,3

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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Mullins, Niamh ; Kang, JooEun ; Campos, Adrian I. ; [et al.]

Elsevier BV ; 2022

In: Biological Psychiatry Vol. 91, No. 3 ( 2022-02), p. 313-327

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In: Biological Psychiatry, Elsevier BV, Vol. 91, No. 3 ( 2022-02), p. 313-327

Type of Medium: Online Resource

ISSN: 0006-3223

URL: Article

DOI: 10.1016/j.biopsych.2021.05.029

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XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 1499907-9

SSG: 12

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