In:
International Journal of Cancer, Wiley, Vol. 146, No. 2 ( 2020-01-15), p. 461-474
Abstract:
What's new? Even though oncogenic human papillomaviruses (HPVs) are major human carcinogens, and metabolic alterations are a hallmark of cancer cells, studies on the potential crosstalk between viral oncogenes and the host cell metabolism in HPV‐transformed cells remain sparse. Here, the authors show that iron chelators, including the topical antifungal agent ciclopirox, efficiently block the expression of the viral E6/E7 oncogenes. Phenotypically, ciclopirox induces mTOR‐independent senescence and, following prolonged application, apoptosis. The findings reveal pronounced anti‐viral and anti‐proliferative activities of ciclopirox in both normoxic and hypoxic HPV‐positive cancer cells, highlighting the potential of ciclopirox as a novel treatment option for HPV‐positive (pre)neoplasias.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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