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  • 1
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    Online Resource
    Altered activation and connectivity of the supplementary motor cortex at motor initiation in Parkinson’s disease patients with freezing
    Elsevier BV ; 2020
    In:  Clinical Neurophysiology Vol. 131, No. 9 ( 2020-09), p. 2171-2180
    Details
    In: Clinical Neurophysiology, Elsevier BV, Vol. 131, No. 9 ( 2020-09), p. 2171-2180
    Type of Medium: Online Resource
    ISSN: 1388-2457
    URL: Article
    DOI: 10.1016/j.clinph.2020.05.023
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1499934-1
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  • 2
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    Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination
    Springer Science and Business Media LLC ; 2009
    In:  Behavioral and Brain Functions Vol. 5, No. 1 ( 2009-12)
    Details
    In: Behavioral and Brain Functions, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2009-12)
    Abstract: To study the neurocognitive profile and its relationship to prefrontal dysfunction in non-demented Parkinson's disease (PD) with deficient haptic perception. Methods Twelve right-handed patients with PD and 12 healthy control subjects underwent thorough neuropsychological testing including Rey complex figure, Rey auditory verbal and figural learning test, figural and verbal fluency, and Stroop test. Test scores reflecting significant differences between patients and healthy subjects were correlated with the individual expression coefficients of one principal component, obtained in a principal component analysis of an oxygen-15-labeled water PET study exploring somatosensory discrimination that differentiated between the two groups and involved prefrontal cortices. Results We found significantly decreased total scores for the verbal learning trials and verbal delayed free recall in PD patients compared with normal volunteers. Further analysis of these parameters using Spearman's ranking correlation showed a significantly negative correlation of deficient verbal recall with expression coefficients of the principal component whose image showed a subcortical-cortical network, including right dorsolateral-prefrontal cortex, in PD patients. Conclusion PD patients with disrupted right dorsolateral prefrontal cortex function and associated diminished somatosensory discrimination are impaired also in verbal memory functions. A negative correlation between delayed verbal free recall and PET activation in a network including the prefrontal cortices suggests that verbal cues and accordingly declarative memory processes may be operative in PD during activities that demand sustained attention such as somatosensory discrimination. Verbal cues may be compensatory in nature and help to non-specifically enhance focused attention in the presence of a functionally disrupted prefrontal cortex.
    Type of Medium: Online Resource
    ISSN: 1744-9081
    URL: Article
    DOI: 10.1186/1744-9081-5-49
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2009
    detail.hit.zdb_id: 2185773-8
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  • 3
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    Coin Rotation Task: A Valid Test for Manual Dexterity in Multiple Sclerosis
    Oxford University Press (OUP) ; 2014
    In:  Physical Therapy Vol. 94, No. 11 ( 2014-11-01), p. 1644-1651
    Details
    In: Physical Therapy, Oxford University Press (OUP), Vol. 94, No. 11 ( 2014-11-01), p. 1644-1651
    Abstract: Impaired manual dexterity is frequent and disabling in people with multiple sclerosis (MS). Therefore, convenient, quick, and validated tests for manual dexterity in people with MS are needed. Objective The aim of this study was to validate the Coin Rotation Task (CRT) for examining manual dexterity in people with MS. Design This was a cross-sectional study. Methods A total of 101 outpatients with MS were assessed with the CRT, the Expanded Disability Status Scale (EDSS), the Scale for the Assessment and Rating of Ataxia (SARA), and the Modified Ashworth Scale (MAS); muscle strength and sensory deficits of the hands were noted. The concurrent validity and diagnostic accuracy of the CRT were determined by comparison with the 9-Hole Peg Test (9HPT). Construct validity was determined by comparison with a valid dexterity questionnaire. Multiple regression analyses were done to explore correlations of the CRT with the EDSS, SARA, MAS, muscle strength, and sensory deficits. Results The CRT correlated significantly with the 9HPT (r=.73, P & lt;.0001), indicating good concurrent validity. The cutoff values for the CRT relative to the 9HPT were 18.75 seconds for the dominant hand (sensitivity=81.5%, specificity=80.0%) and 19.25 seconds for the nondominant hand (sensitivity=90.3%, specificity=81.8%); these values indicated good diagnostic accuracy. Furthermore, the CRT correlated significantly with the dexterity questionnaire (r=−.49, P & lt;.0001), indicating moderate construct validity. Multiple regression analyses revealed that the EDSS was the strongest predictor for impaired dexterity. Limitations Most of the people examined had relapsing-remitting MS and EDSS scores of up to 7. Conclusions This study validated the CRT as a test that can be used easily and quickly to evaluate manual dexterity in people with MS.
    Type of Medium: Online Resource
    ISSN: 0031-9023 , 1538-6724
    URL: Article
    DOI: 10.2522/ptj.20130252
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2014
    detail.hit.zdb_id: 2008745-7
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  • 4
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    Left parietal activation related to planning, executing and suppressing praxis hand movements
    Elsevier BV ; 2009
    In:  Clinical Neurophysiology Vol. 120, No. 5 ( 2009-05), p. 980-986
    Details
    In: Clinical Neurophysiology, Elsevier BV, Vol. 120, No. 5 ( 2009-05), p. 980-986
    Type of Medium: Online Resource
    ISSN: 1388-2457
    URL: Article
    DOI: 10.1016/j.clinph.2009.02.161
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2009
    detail.hit.zdb_id: 1499934-1
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  • 5
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    Abnormality of motor cortex excitability in peripherally induced dystonia
    Wiley ; 2007
    In:  Movement Disorders Vol. 22, No. 8 ( 2007-06-15), p. 1186-1189
    Details
    In: Movement Disorders, Wiley, Vol. 22, No. 8 ( 2007-06-15), p. 1186-1189
    Abstract: It is widely accepted that peripheral trauma such as soft tissue injuries can trigger dystonia, although little is known about the underlying mechanism. Because peripheral injury only rarely appears to elicit dystonia, a predisposing vulnerability in cortical motor areas might play a role. Using single and paired‐pulse pulse transcranial magnetic stimulation, we evaluated motor cortex excitability of a hand muscle in a patient with peripherally induced foot dystonia, in her brother with craniocervical dystonia, and in her unaffected sister, and compared their results to those from a group of normal subjects. In the patient with peripherally induced dystonia, we found a paradoxical intracortical facilitation at short interstimulus intervals of 3 and 5 milliseconds, at which regular intracortical inhibition (ICI) occurred in healthy subjects. These findings suggest that the foot dystonia may have been precipitated as the result of a preexisting abnormality of motor cortex excitability. Furthermore, the abnormality of ICI in her brother and sister indicates that altered motor excitability may be a hereditary predisposition. The study demonstrates that the paired‐pulse technique is a useful tool to assess individual vulnerability, which can be particularly relevant when the causal association between trauma and dystonia is less evident. © 2007 Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v22:8
    DOI: 10.1002/mds.21424
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2041249-6
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  • 6
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    Data_Sheet_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Neurology Vol. 12 ( 2021-9-22)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 12 ( 2021-9-22)
    Abstract: Background: Magnetic resonance-guided high-intensity focused ultrasound (MRgHiFUS) has evolved into a viable ablative treatment option for functional neurosurgery. However, it is not clear yet, how this new technology should be integrated into current and established clinical practice and a consensus should be found about recommended indications, stereotactic targets, patient selection, and outcome measurements. Objective: To sum up and unify current knowledge and clinical experience of Swiss neurological and neurosurgical communities regarding MRgHiFUS interventions for brain disorders to be published as a national consensus paper. Methods: Eighteen experienced neurosurgeons and neurologists practicing in Switzerland in the field of movement disorders and one health physicist representing 15 departments of 12 Swiss clinical centers and 5 medical societies participated in the workshop and contributed to the consensus paper. All experts have experience with current treatment modalities or with MRgHiFUS. They were invited to participate in two workshops and consensus meetings and one online meeting. As part of workshop preparations, a thorough literature review was undertaken and distributed among participants together with a list of relevant discussion topics. Special emphasis was put on current experience and practice, and areas of controversy regarding clinical application of MRgHiFUS for functional neurosurgery. Results: The recommendations addressed lesioning for treatment of brain disorders in general, and with respect to MRgHiFUS indications, stereotactic targets, treatment alternatives, patient selection and management, standardization of reporting and follow-up, and initialization of a national registry for interventional therapies of movement disorders. Good clinical evidence is presently only available for unilateral thalamic lesioning in treating essential tremor or tremor-dominant Parkinson's disease and, to a minor extent, for unilateral subthalamotomy for Parkinson's disease motor features. However, the workgroup unequivocally recommends further exploration and adaptation of MRgHiFUS-based functional lesioning interventions and confirms the need for outcome-based evaluation of these approaches based on a unified registry. MRgHiFUS and DBS should be evaluated by experts familiar with both methods, as they are mutually complementing therapy options to be appreciated for their distinct advantages and potential. Conclusion: This multidisciplinary consensus paper is a representative current recommendation for safe implementation and standardized practice of MRgHiFUS treatments for functional neurosurgery in Switzerland.
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    URL: Article
    DOI: 10.3389/fneur.2021.722762
    DOI: 10.3389/fneur.2021.722762.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2564214-5
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  • 7
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    German Translation and Validation of the “Freezing of Gait Questionnaire” in Patients with Parkinson’s Disease
    Hindawi Limited ; 2015
    In:  Parkinson's Disease Vol. 2015 ( 2015), p. 1-5
    Details
    In: Parkinson's Disease, Hindawi Limited, Vol. 2015 ( 2015), p. 1-5
    Abstract: Background . Freezing of Gait (FOG) is a disabling parkinsonian symptom. The Freezing of Gait Questionnaire (FOG-Q) reliably detects FOG in patients with Parkinson’s disease (PD). Objectives . The aim of this study was to develop a German translated version of the FOG-Q and to assess its validity. Methods . The translation was accomplished using forward-backward-translation. The construct validity of the FOG-Q was examined in twenty-seven German native speaking PD patients. Convergent validity was assessed by correlating the FOG-Q with the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) II-III, the Parkinson Disease Questionnaire 39 (PDQ-39), and the Timed Up and Go Test (TUG). Divergent validity was assessed by correlating the FOG-Q with the MDS-UPDRS I. The internal consistency was measured using Cronbach’s alpha (C α ). Results . A good internal structure of the FOG-Q was found ( C α = 0.83 ). Significant moderate correlations between the FOG-Q and the MDS-UPDRS item 2.13 (freezing) ( r s = 0.568 , P = 0.002 ) and between the FOG-Q and the PDQ-39 subscale mobility ( r s = 0.516 , P = 0.006 ) were found. The lack of correlation with the MDS-UPDRS I demonstrated good divergent validity. Conclusion . The German FOG-Q is a valid tool to assess FOG in German native speaking PD patients.
    Type of Medium: Online Resource
    ISSN: 2090-8083 , 2042-0080
    URL: Article
    DOI: 10.1155/2015/982058
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2573854-9
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  • 8
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    Exergaming-Based Dexterity Training in Persons With Parkinson Disease: A Pilot Feasibility Study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of Neurologic Physical Therapy Vol. 43, No. 3 ( 2019-07), p. 168-174
    Details
    In: Journal of Neurologic Physical Therapy, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 3 ( 2019-07), p. 168-174
    Abstract: Many individuals with Parkinson disease (PD) suffer from impaired dexterity, which impacts activities of daily living and quality of life. Exergaming, video game-based training with augmented virtual reality, may have value for improving function. The aim of the present pilot study was to comprehensively evaluate the feasibility of a dexterity training program using exergaming, in individuals with PD. Methods: Ten participants with PD (aged between 55 and 75 years, Hoehn and Yahr stages II-IV) trained over a period of 4 weeks, twice a week for 30 minutes. Baseline (T0) and postintervention (T1) assessments were done. Primary outcomes with respect to feasibility were the adherence rate, open-end questions, the level of participation (Pittsburgh Rehabilitation Participation Scale), and the usability (System Usability Scale). Dexterous function was measured with the Nine-Hole Peg Test and the Dexterity Questionnaire-24. Upper limb motor impairment was assessed by a modified version of the Movement Disorders Society Unified Parkinson's Disease Rating Scale III. Finally, quality of life was assessed by the 39-item Parkinson's Disease Questionnaire (PDQ-39). Results: Adherence rate was 99%, motivation increased significantly from 3.9 to 4.8 (Pittsburgh Rehabilitation Participation Scale, P = 0.03), and system usability of the exergaming system was acceptable to very good. Regarding potential efficacy, participants with impaired dexterity at T0 significantly improved in the Nine-Hole Peg Test and the PDQ-39. Discussions and Conclusions: The outcomes of this pilot study suggest that exergaming is feasible and has potential to improve dexterity in individuals with PD. Its efficacy should be investigated in a properly powered randomized controlled trial. Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A270).
    Type of Medium: Online Resource
    ISSN: 1557-0576
    URL: Article
    DOI: 10.1097/NPT.0000000000000278
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2259972-1
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  • 9
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    Feasibility of a Home-Based Tablet App for Dexterity Training in Multiple Sclerosis: Usability Study
    JMIR Publications Inc. ; 2020
    In:  JMIR mHealth and uHealth Vol. 8, No. 6 ( 2020-6-9), p. e18204-
    Details
    In: JMIR mHealth and uHealth, JMIR Publications Inc., Vol. 8, No. 6 ( 2020-6-9), p. e18204-
    Abstract: Persons with multiple sclerosis (MS) often experience dexterous difficulties during the performance of activities of daily living, such as fastening buttons, handling coins, or writing, therefore impacting their health-related quality of life. Mobile health (mHealth) solutions, such as tablet apps, may be used to train impaired dexterous skills. The feasibility of a tablet app–based dexterity home-based intervention in MS (TAD-MS) has not been explored yet in persons with MS. Objective The aim of this pilot study was to evaluate the feasibility and usability of home-based dexterity training with a tablet app in both persons with MS and healthy subjects. Methods A total of 9 persons with MS, aged 35-71 years, with an Expanded Disability Status Scale score between 2 and 7.5, performed the TAD-MS for 4 weeks, five times a week, with each training session lasting approximately 30 minutes. Participants’ impaired dexterity was measured by the Nine-Hole Peg Test. A total of 10 age-matched healthy subjects also tested and rated the usability of the app. Outcome measures were the adherence rate as well as usability measured by the System Usability Scale and a Custom User Engagement Questionnaire (CUEQ). Results High feasibility of the tablet app–based dexterity training program was shown by a 97% adherence rate to the training protocol (ie, mean 19.4/20 sessions completed, SD 0.8). High system usability scores (ie, mean 85.39%, SD 11.67) and overall high scores given in the CUEQ (ie, mean 8.2/10, SD 1.4) further point to high usability of the app. Neither demographic variables nor dexterity levels affected the use of the app. Conclusions This pilot study is the first to demonstrate high feasibility and usability of a new tablet app–based dexterity home-based training program among both persons with MS and healthy individuals. Whether this kind of training improves dexterity will need to be evaluated in a randomized controlled trial.
    Type of Medium: Online Resource
    ISSN: 2291-5222
    URL: Article
    DOI: 10.2196/18204
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2020
    detail.hit.zdb_id: 2719220-9
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  • 10
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    Limbic Interference During Social Action Planning in Schizophrenia
    Oxford University Press (OUP) ; 2018
    In:  Schizophrenia Bulletin Vol. 44, No. 2 ( 2018-02-15), p. 359-368
    Details
    In: Schizophrenia Bulletin, Oxford University Press (OUP), Vol. 44, No. 2 ( 2018-02-15), p. 359-368
    Type of Medium: Online Resource
    ISSN: 0586-7614 , 1745-1701
    URL: Article
    DOI: 10.1093/schbul/sbx059
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
    detail.hit.zdb_id: 2180196-4
    SSG: 15,3
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