In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2022-8-24), p. e0273036-
Abstract:
The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases such as obesity, diabetes, cancer and also neurodegenerative disease, such as Parkinson, Huntington and Alzheimer’s disease (AD), although whether causative, consequence or merely an epiphenomenon is still under investigation. In the present study, we performed a metabologenomic analysis of stool samples from a mouse model of AD, the 3xTgAD. We found a significant change in the microbiota of AD mice compared to WT, with a longitudinal divergence of the F/B ratio, a parameter suggesting a gut dysbiosis. Moreover, AD mice showed a significant decrease of some amino acids, while data integration revealed a dysregulated production of desaminotyrosine (DAT) and dihydro-3-coumaric acid. Collectively, our data show a dysregulated gut microbiota associated to the onset and progression of AD, also indicating that a dysbiosis can occur prior to significant clinical signs, evidenced by early SCFA alterations, compatible with gut inflammation.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0273036
DOI:
10.1371/journal.pone.0273036.g001
DOI:
10.1371/journal.pone.0273036.g002
DOI:
10.1371/journal.pone.0273036.g003
DOI:
10.1371/journal.pone.0273036.g004
DOI:
10.1371/journal.pone.0273036.g005
DOI:
10.1371/journal.pone.0273036.g006
DOI:
10.1371/journal.pone.0273036.g007
DOI:
10.1371/journal.pone.0273036.s001
DOI:
10.1371/journal.pone.0273036.s002
DOI:
10.1371/journal.pone.0273036.s003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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