In:
Journal of Cutaneous Pathology, Wiley, Vol. 36, No. 12 ( 2009-12), p. 1312-1315
Abstract:
Syringomas are architecturally complex tumors composed of small, cystically dilated segments of dermal eccrine duct. Syringomas typically form isolated flesh‐colored periorbital papules, however, in a peculiar condition termed eruptive syringoma; scores develop simultaneously in near confluence over a large surface area. While traditionally regarded as a neoplasm, more recent observations indicate eruptive syringoma is a reactive proliferation secondary to autoimmune disruption of the acrosyringium. We present the case of a 44‐year‐old woman with eruptive syringoma of the labia majora and prominent lymphocytic inflammation in the acrosyringium. Immunohistochemical stains confirm that the infiltrate is composed of CD4+ and CD8+ T cells, without significant CD20 B cells or CD138 plasma cells. Sequential sections of the syringoma reveal a complex 3‐dimensional architecture with functionally isolated cysts, not connected to adjacent cysts or ducts by a discernable epithelium. These findings support the conclusion that eruptive syringoma is a tortuous proliferation of dermal eccrine ducts and fibrous stroma secondary to autoimmune destruction of the acrosyringium. Conceptually, the disorganized expansion of an eccrine duct syringoma may be analogous to a peripheral nerve traumatic neuroma.
Type of Medium:
Online Resource
ISSN:
0303-6987
,
1600-0560
DOI:
10.1111/cup.2009.36.issue-12
DOI:
10.1111/j.1600-0560.2009.01277.x
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2018100-0
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