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The Proto-MHC of Placozoans, a Region Specialized in Cellular Stress and Ubiquitination/Proteasome Pathways

Suurväli, Jaanus ; Jouneau, Luc ; Thépot, Dominique ; [et al.]

The American Association of Immunologists ; 2014

In: The Journal of Immunology Vol. 193, No. 6 ( 2014-09-15), p. 2891-2901

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In: The Journal of Immunology, The American Association of Immunologists, Vol. 193, No. 6 ( 2014-09-15), p. 2891-2901

Abstract: The MHC is a large genetic region controlling Ag processing and recognition by T lymphocytes in vertebrates. Approximately 40% of its genes are implicated in innate or adaptive immunity. A putative proto-MHC exists in the chordate amphioxus and in the fruit fly, indicating that a core MHC region predated the emergence of the adaptive immune system in vertebrates. In this study, we identify a putative proto-MHC with archetypal markers in the most basal branch of Metazoans—the placozoan Trichoplax adhaerens, indicating that the proto-MHC is much older than previously believed—and present in the common ancestor of bilaterians (contains vertebrates) and placozoans. Our evidence for a T. adhaerens proto-MHC was based on macrosynteny and phylogenetic analyses revealing approximately one third of the multiple marker sets within the human MHC-related paralogy groups have unique counterparts in T. adhaerens, consistent with two successive whole genome duplications during early vertebrate evolution. A genetic ontologic analysis of the proto-MHC markers in T. adhaerens was consistent with its involvement in defense, showing proteins implicated in antiviral immunity, stress response, and ubiquitination/proteasome pathway. Proteasome genes psma, psmb, and psmd are present, whereas the typical markers of adaptive immunity, such as MHC class I and II, are absent. Our results suggest that the proto-MHC was involved in intracellular intrinsic immunity and provide insight into the primordial architecture and functional landscape of this region that later in evolution became associated with numerous genes critical for adaptive immunity in vertebrates.

Type of Medium: Online Resource

ISSN: 0022-1767 , 1550-6606

URL: Article

DOI: 10.4049/jimmunol.1401177

RVK:

XA 54100

RVK:

XA 10000

Language: English

Publisher: The American Association of Immunologists

Publication Date: 2014

detail.hit.zdb_id: 1475085-5

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R4 regulators of G protein signaling (RGS) identify an ancient MHC-linked synteny group

Jaanus, Suurv�li ; Jacques, Robert ; Pierre, Boudinot ; [et al.]

Frontiers Media SA ; 2013

In: Frontiers in Immunology Vol. 4 ( 2013)

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In: Frontiers in Immunology, Frontiers Media SA, Vol. 4 ( 2013)

Type of Medium: Online Resource

ISSN: 1664-3224

URL: Article

DOI: 10.3389/conf.fimmu.2013.02.00345

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2013

detail.hit.zdb_id: 2606827-8

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P2X4: A fast and sensitive purinergic receptor

Suurväli, Jaanus ; Boudinot, Pierre ; Kanellopoulos, Jean ; [et al.]

Elsevier BV ; 2017

In: Biomedical Journal Vol. 40, No. 5 ( 2017-10), p. 245-256

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In: Biomedical Journal, Elsevier BV, Vol. 40, No. 5 ( 2017-10), p. 245-256

Type of Medium: Online Resource

ISSN: 2319-4170

URL: Article

DOI: 10.1016/j.bj.2017.06.010

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 2698541-X

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R4 regulators of G protein signaling (RGS) identify an ancient MHC-linked synteny group

Suurväli, Jaanus ; Robert, Jacques ; Boudinot, Pierre ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Immunogenetics Vol. 65, No. 2 ( 2013-2), p. 145-156

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In: Immunogenetics, Springer Science and Business Media LLC, Vol. 65, No. 2 ( 2013-2), p. 145-156

Type of Medium: Online Resource

ISSN: 0093-7711 , 1432-1211

URL: Article

DOI: 10.1007/s00251-012-0661-x

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 1398344-1

SSG: 12

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Image_7.TIFF

Paalme, Viiu ; Rump, Airi ; Mädo, Kati ; [et al.]

Frontiers Media SA ; 2019

In: Frontiers in Immunology Vol. 10 ( 2019-9-6)

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In: Frontiers in Immunology, Frontiers Media SA, Vol. 10 ( 2019-9-6)

Type of Medium: Online Resource

ISSN: 1664-3224

URL: Article

DOI: 10.3389/fimmu.2019.02074

DOI: 10.3389/fimmu.2019.02074.s001

DOI: 10.3389/fimmu.2019.02074.s002

DOI: 10.3389/fimmu.2019.02074.s003

DOI: 10.3389/fimmu.2019.02074.s004

DOI: 10.3389/fimmu.2019.02074.s005

DOI: 10.3389/fimmu.2019.02074.s006

DOI: 10.3389/fimmu.2019.02074.s007

DOI: 10.3389/fimmu.2019.02074.s008

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2019

detail.hit.zdb_id: 2606827-8

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Rump, Airi ; Smolander, Olli Pekka ; Rüütel Boudinot, Sirje ; [et al.]

Frontiers Media SA ; 2020

In: Frontiers in Immunology Vol. 11 ( 2020-2-6)

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In: Frontiers in Immunology, Frontiers Media SA, Vol. 11 ( 2020-2-6)

Type of Medium: Online Resource

ISSN: 1664-3224

URL: Article

DOI: 10.3389/fimmu.2020.00113

DOI: 10.3389/fimmu.2020.00113.s001

DOI: 10.3389/fimmu.2020.00113.s002

DOI: 10.3389/fimmu.2020.00113.s003

DOI: 10.3389/fimmu.2020.00113.s004

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2020

detail.hit.zdb_id: 2606827-8

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Various V-J rearrangement efficiencies shape the mouse λ B cell repertoire

Boudinot, Pierre ; Rueff-Juy, Dominique ; Drapier, Anne-Marie ; [et al.]

Wiley ; 1995

In: European Journal of Immunology Vol. 25, No. 9 ( 1995-09), p. 2499-2505

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In: European Journal of Immunology, Wiley, Vol. 25, No. 9 ( 1995-09), p. 2499-2505

Type of Medium: Online Resource

ISSN: 0014-2980 , 1521-4141

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/eji.v25:9

DOI: 10.1002/(ISSN)1521-4141

DOI: 10.1002/eji.1830250914

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 1995

detail.hit.zdb_id: 1491907-2

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Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes

Passoni, Gabriella ; Langevin, Christelle ; Palha, Nuno ; [et al.]

The Company of Biologists ; 2017

In: Disease Models & Mechanisms

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In: Disease Models & Mechanisms, The Company of Biologists

Abstract: Alphaviruses, such as chikungunya (CHIKV) and Sindbis virus (SINV), are vector‑borne pathogens that cause acute illnesses in humans and are sometimes associated with neuropathies, especially in infants and elderly patients. Little is known about their entry mechanism in the central nervous system (CNS), even for SINV, which has been used extensively as a model for viral encephalopathies. We previously established a CHIKV infection model in the optically transparent zebrafish larva; here we describe a new SINV infection model in this host. We imaged in vivo the onset and the progression of the infection caused by intravenous SINV inoculation. Similar to that described for CHIKV, infection in the periphery was detected early and was transient, while CNS infection started at later time points and was persistent or progressive. We then tested the possible mechanisms of neuroinvasion by CHIKV and SINV. Neither virus relied on macrophage-mediated transport to access the CNS. CHIKV, but not SINV, always infects endothelial cells of the brain vasculature. By contrast, axonal transport was much more efficient with SINV than CHIKV, both from periphery to the CNS or between neural tissues. Thus, the preferred mechanisms of neuroinvasion by these two related viruses are distinct, providing a powerful imaging-friendly system to compare mechanisms and prevention methods of encephalopathies.

Type of Medium: Online Resource

ISSN: 1754-8411 , 1754-8403

URL: Article

DOI: 10.1242/dmm.029231

Language: English

Publisher: The Company of Biologists

Publication Date: 2017

detail.hit.zdb_id: 2451104-3

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The λ B Cell Repertoire of K-Deficient Mice

Sanchez, Pierre ; Rueff-juy, Dominique ; Boudinot, Pierre ; [et al.]

Informa UK Limited ; 1996

In: International Reviews of Immunology Vol. 13, No. 4 ( 1996-01), p. 357-368

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In: International Reviews of Immunology, Informa UK Limited, Vol. 13, No. 4 ( 1996-01), p. 357-368

Type of Medium: Online Resource

ISSN: 0883-0185 , 1563-5244

URL: Article

DOI: 10.3109/08830189609061758

Language: English

Publisher: Informa UK Limited

Publication Date: 1996

detail.hit.zdb_id: 2030424-9

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Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish

Boudinot, Pierre ; van der Aa, Lieke M. ; Jouneau, Luc ; [et al.]

Public Library of Science (PLoS) ; 2011

In: PLoS ONE Vol. 6, No. 7 ( 2011-7-15), p. e22022-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 6, No. 7 ( 2011-7-15), p. e22022-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0022022

DOI: 10.1371/journal.pone.0022022.g001

DOI: 10.1371/journal.pone.0022022.g002

DOI: 10.1371/journal.pone.0022022.g003

DOI: 10.1371/journal.pone.0022022.g004

DOI: 10.1371/journal.pone.0022022.g005

DOI: 10.1371/journal.pone.0022022.g006

DOI: 10.1371/journal.pone.0022022.g007

DOI: 10.1371/journal.pone.0022022.g008

DOI: 10.1371/journal.pone.0022022.t001

DOI: 10.1371/journal.pone.0022022.t002

DOI: 10.1371/journal.pone.0022022.s001

DOI: 10.1371/journal.pone.0022022.s002

DOI: 10.1371/journal.pone.0022022.s003

DOI: 10.1371/journal.pone.0022022.s004

DOI: 10.1371/journal.pone.0022022.s005

DOI: 10.1371/journal.pone.0022022.s006

DOI: 10.1371/journal.pone.0022022.s007

DOI: 10.1371/journal.pone.0022022.s008

DOI: 10.1371/journal.pone.0022022.s009

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2011

detail.hit.zdb_id: 2267670-3

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