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Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia

Aury, Jean-Marc ; Jaillon, Olivier ; Duret, Laurent ; [et al.]

Springer Science and Business Media LLC ; 2006

In: Nature Vol. 444, No. 7116 ( 2006-11), p. 171-178

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In: Nature, Springer Science and Business Media LLC, Vol. 444, No. 7116 ( 2006-11), p. 171-178

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature05230

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2006

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

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Genome-defence small RNAs exapted for epigenetic mating-type inheritance

Singh, Deepankar Pratap ; Saudemont, Baptiste ; Guglielmi, Gérard ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Nature Vol. 509, No. 7501 ( 2014-05-22), p. 447-452

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In: Nature, Springer Science and Business Media LLC, Vol. 509, No. 7501 ( 2014-05-22), p. 447-452

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature13318

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

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Functional specialization of Piwi proteins in Paramecium tetraurelia from post-transcriptional gene silencing to genome remodelling

Bouhouche, Khaled ; Gout, Jean-François ; Kapusta, Aurélie ; [et al.]

Oxford University Press (OUP) ; 2011

In: Nucleic Acids Research Vol. 39, No. 10 ( 2011-5), p. 4249-4264

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In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 39, No. 10 ( 2011-5), p. 4249-4264

Type of Medium: Online Resource

ISSN: 1362-4962 , 0305-1048

URL: Article

DOI: 10.1093/nar/gkq1283

RVK:

WA 15000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2011

detail.hit.zdb_id: 1472175-2

SSG: 12

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TTC12 Loss-of-Function Mutations Cause Primary Ciliary Dyskinesia and Unveil Distinct Dynein Assembly Mechanisms in Motile Cilia Versus Flagella

Thomas, Lucie ; Bouhouche, Khaled ; Whitfield, Marjorie ; [et al.]

Elsevier BV ; 2020

In: The American Journal of Human Genetics Vol. 106, No. 2 ( 2020-02), p. 153-169

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In: The American Journal of Human Genetics, Elsevier BV, Vol. 106, No. 2 ( 2020-02), p. 153-169

Type of Medium: Online Resource

ISSN: 0002-9297

URL: Article

DOI: 10.1016/j.ajhg.2019.12.010

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 1473813-2

SSG: 12

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La paramécie, un organisme modèle pour étudier la ciliogenèse et les maladies ciliaires

Bouhouche, Khaled ; Le Borgne, Pierrick ; Lemullois, Michel ; [et al.]

EDP Sciences ; 2021

In: médecine/sciences Vol. 37, No. 6-7 ( 2021-06), p. 632-638

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In: médecine/sciences, EDP Sciences, Vol. 37, No. 6-7 ( 2021-06), p. 632-638

Abstract: The cilium is a cell extension forming a distinct compartment of eukaryotic cell body with a complex and dynamic structure. This structure is highly conserved across species and ensures various functions as sensory and motility. In humans, ciliary dysfunction results in diseases (ciliopathies) that can affect all organs. Thanks to its complex ciliary structure, the unicellular and ciliated microorganism, Paramecium , constitutes a model of choice not only to study the structure, assembly and function of cilia but also to validate the specific role of mutations of genes linked to the ciliopathies.

Type of Medium: Online Resource

ISSN: 0767-0974 , 1958-5381

URL: Article

DOI: 10.1051/medsci/2021087

Language: French

Publisher: EDP Sciences

Publication Date: 2021

detail.hit.zdb_id: 2049442-7

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Centrin diversity and basal body patterning across evolution: new insights from Paramecium

Aubusson-Fleury, Anne ; Balavoine, Guillaume ; Lemullois, Michel ; [et al.]

The Company of Biologists ; 2017

In: Biology Open

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In: Biology Open, The Company of Biologists

Abstract: First discovered in unicellular eukaryotes, centrins play crucial roles in basal body duplication and anchoring mechanisms. While the evolutionary status of the founding members of the family, Centrin2/Vfl2 and Centrin3/cdc31 has long been investigated, the evolutionary origin of other members of the family has received less attention. Using a phylogeny of ciliate centrins, we identify two other centrin families, the ciliary centrins and the centrins present in the contractile filaments (ICL centrins). In this paper, we carry on the functional analysis of still not well known centrins, the ICL1e subfamily identified in Paramecium, and show their requirement for correct basal body anchoring through interactions with Centrin2 and Centrin3. Using Paramecium as well as an Eukaryote-wide sampling of centrins from completely sequenced genomes, we revisited the evolutionary story of centrins. Their phylogeny shows that the centrins associated with the ciliate contractile filaments are widespread in eukaryotic lineages and could be as ancient as Centrin2 and Centrin3.

Type of Medium: Online Resource

ISSN: 2046-6390

URL: Article

DOI: 10.1242/bio.024273

Language: English

Publisher: The Company of Biologists

Publication Date: 2017

detail.hit.zdb_id: 2632264-X

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Translational control of intron splicing in eukaryotes

Jaillon, Olivier ; Bouhouche, Khaled ; Gout, Jean-François ; [et al.]

Springer Science and Business Media LLC ; 2008

In: Nature Vol. 451, No. 7176 ( 2008-1), p. 359-362

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In: Nature, Springer Science and Business Media LLC, Vol. 451, No. 7176 ( 2008-1), p. 359-362

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature06495

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2008

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

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Altering a Gene Involved in Nuclear Distribution Increases the Repeat-Induced Point Mutation Process in the Fungus Podospora anserina

Bouhouche, Khaled ; Zickler, Denise ; Debuchy, Robert ; [et al.]

Oxford University Press (OUP) ; 2004

In: Genetics Vol. 167, No. 1 ( 2004-05-01), p. 151-159

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In: Genetics, Oxford University Press (OUP), Vol. 167, No. 1 ( 2004-05-01), p. 151-159

Abstract: Repeat-induced point mutation (RIP) is a homology-dependent gene-silencing mechanism that introduces C:G-to-T:A transitions in duplicated DNA segments. Cis-duplicated sequences can also be affected by another mechanism called premeiotic recombination (PR). Both are active over the sexual cycle of some filamentous fungi, e.g., Neurospora crassa and Podospora anserina. During the sexual cycle, several developmental steps require precise nuclear movement and positioning, but connections between RIP, PR, and nuclear distributions have not yet been established. Previous work has led to the isolation of ami1, the P. anserina ortholog of the Aspergillus nidulans apsA gene, which is required for nuclear positioning. We show here that ami1 is involved in nuclear distribution during the sexual cycle and that alteration of ami1 delays the fruiting-body development. We also demonstrate that ami1 alteration affects loss of transgene functions during the sexual cycle. Genetically linked multiple copies of transgenes are affected by RIP and PR much more frequently in an ami1 mutant cross than in a wild-type cross. Our results suggest that the developmental slowdown of the ami1 mutant during the period of RIP and PR increases time exposure to the duplication detection system and thus increases the frequency of RIP and PR.

Type of Medium: Online Resource

ISSN: 1943-2631

URL: Article

DOI: 10.1534/genetics.167.1.151

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2004

detail.hit.zdb_id: 1477228-0

SSG: 12

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An siRNA-based screen in C2C12 myoblasts identifies novel genes involved in myogenic differentiation

Alwan, Rayan ; Bruel, Ange-Line ; Da Silva, Anne ; [et al.]

Elsevier BV ; 2017

In: Experimental Cell Research Vol. 359, No. 1 ( 2017-10), p. 145-153

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In: Experimental Cell Research, Elsevier BV, Vol. 359, No. 1 ( 2017-10), p. 145-153

Type of Medium: Online Resource

ISSN: 0014-4827

URL: Article

DOI: 10.1016/j.yexcr.2017.07.037

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 1466780-0

SSG: 12

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The evolutionary conserved proteins CEP90, FOPNL, and OFD1 recruit centriolar distal appendage proteins to initiate their assembly

Le Borgne, Pierrick ; Greibill, Logan ; Laporte, Marine Hélène ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS Biology Vol. 20, No. 9 ( 2022-9-7), p. e3001782-

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In: PLOS Biology, Public Library of Science (PLoS), Vol. 20, No. 9 ( 2022-9-7), p. e3001782-

Abstract: In metazoa, cilia assembly is a cellular process that starts with centriole to basal body maturation, migration to the cell surface, and docking to the plasma membrane. Basal body docking involves the interaction of both the distal end of the basal body and the transition fibers/distal appendages, with the plasma membrane. Mutations in numerous genes involved in basal body docking and transition zone assembly are associated with the most severe ciliopathies, highlighting the importance of these events in cilium biogenesis. In this context, the ciliate Paramecium has been widely used as a model system to study basal body and cilia assembly. However, despite the evolutionary conservation of cilia assembly events across phyla, whether the same molecular players are functionally conserved, is not fully known. Here, we demonstrated that CEP90, FOPNL, and OFD1 are evolutionary conserved proteins crucial for ciliogenesis. Using ultrastructure expansion microscopy, we unveiled that these proteins localize at the distal end of both centrioles/basal bodies in Paramecium and mammalian cells. Moreover, we found that these proteins are recruited early during centriole duplication on the external surface of the procentriole. Functional analysis performed both in Paramecium and mammalian cells demonstrate the requirement of these proteins for distal appendage assembly and basal body docking. Finally, we show that mammalian centrioles require another component, Moonraker (MNR), to recruit OFD1, FOPNL, and CEP90, which will then recruit the distal appendage proteins CEP83, CEP89, and CEP164. Altogether, we propose that this OFD1, FOPNL, and CEP90 functional module is required to determine in mammalian cells the future position of distal appendage proteins.

Type of Medium: Online Resource

ISSN: 1545-7885

URL: Article

DOI: 10.1371/journal.pbio.3001782

DOI: 10.1371/journal.pbio.3001782.g001

DOI: 10.1371/journal.pbio.3001782.g002

DOI: 10.1371/journal.pbio.3001782.g003

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DOI: 10.1371/journal.pbio.3001782.g007

DOI: 10.1371/journal.pbio.3001782.g008

DOI: 10.1371/journal.pbio.3001782.g009

DOI: 10.1371/journal.pbio.3001782.s001

DOI: 10.1371/journal.pbio.3001782.s002

DOI: 10.1371/journal.pbio.3001782.s003

DOI: 10.1371/journal.pbio.3001782.s004

DOI: 10.1371/journal.pbio.3001782.s005

DOI: 10.1371/journal.pbio.3001782.s006

DOI: 10.1371/journal.pbio.3001782.s007

DOI: 10.1371/journal.pbio.3001782.s008

DOI: 10.1371/journal.pbio.3001782.s009

DOI: 10.1371/journal.pbio.3001782.s010

DOI: 10.1371/journal.pbio.3001782.s011

DOI: 10.1371/journal.pbio.3001782.s012

DOI: 10.1371/journal.pbio.3001782.s013

DOI: 10.1371/journal.pbio.3001782.s014

DOI: 10.1371/journal.pbio.3001782.s015

DOI: 10.1371/journal.pbio.3001782.s016

DOI: 10.1371/journal.pbio.3001782.s017

DOI: 10.1371/journal.pbio.3001782.s018

DOI: 10.1371/journal.pbio.3001782.s019

DOI: 10.1371/journal.pbio.3001782.s020

DOI: 10.1371/journal.pbio.3001782.s021

DOI: 10.1371/journal.pbio.3001782.s022

DOI: 10.1371/journal.pbio.3001782.s023

DOI: 10.1371/journal.pbio.3001782.s024

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2126773-X

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