In:
Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 80, No. 5 ( 2002-05-01), p. 388-395
Abstract:
Melanin-concentrating hormone (MCH) is a cyclic neuropeptide of nineteen amino acids in mammals. Its involvement in the feeding behaviour has been well established during the last few years. A first receptor subtype, now termed MCH1R, was discovered in 1999, following the desorphanisation of the SLC1 orphan receptor, using either reverse pharmacology or systematic screening of agonist candidates. A second MCH receptor, MCH2R, has been discovered recently, by several groups working on data mining of genomic banks. The molecular pharmacology of these two receptors is only described on the basis of the action of peptides derived from MCH. The present review tentatively summarizes the knowledge on these two receptors and presents the first attempts to discover new classes of antagonists that might have major roles in the control of obesity and feeding behaviour.Key words: melanin-concentrating hormone, melanin-concentrating hormone receptor, SLC-1, food intake, obesity.
Type of Medium:
Online Resource
ISSN:
0008-4212
,
1205-7541
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
2002
detail.hit.zdb_id:
2004356-9
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