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Detectable clonal mosaicism and its relationship to aging and cancer

Jacobs, Kevin B ; Yeager, Meredith ; Zhou, Weiyin ; [et al.]

Springer Science and Business Media LLC ; 2012

In: Nature Genetics Vol. 44, No. 6 ( 2012-6), p. 651-658

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 44, No. 6 ( 2012-6), p. 651-658

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.2270

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XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2012

detail.hit.zdb_id: 1494946-5

SSG: 12

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Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Fang, Jun ; Jia, Jinping ; Makowski, Matthew ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Nature Communications Vol. 8, No. 1 ( 2017-04-27)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2017-04-27)

Abstract: Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L ) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity. Transcriptional gene silencing of this regulatory element repressed TERT expression in an allele-specific manner. Proteomic analysis identifies allele-preferred binding of Zinc finger protein 148 (ZNF148) to rs36115365-C, further supported by binding of purified recombinant ZNF148. Knockdown of ZNF148 results in reduced TERT expression, telomerase activity and telomere length. Our results indicate that the association with chr5p15.33-Region 2 may be explained by rs36115365, a variant influencing TERT expression via ZNF148 in a manner consistent with elevated TERT in carriers of the C allele.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms15034

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2553671-0

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Intake of Vegetables, Legumes, and Fruit, and Risk for All-Cause, Cardiovascular, and Cancer Mortality in a European Diabetic Population

Nöthlings, Ute ; Schulze, Matthias B. ; Weikert, Cornelia ; [et al.]

Elsevier BV ; 2008

In: The Journal of Nutrition Vol. 138, No. 4 ( 2008-04), p. 775-781

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In: The Journal of Nutrition, Elsevier BV, Vol. 138, No. 4 ( 2008-04), p. 775-781

Type of Medium: Online Resource

ISSN: 0022-3166

URL: Article

DOI: 10.1093/jn/138.4.775

Language: English

Publisher: Elsevier BV

Publication Date: 2008

detail.hit.zdb_id: 1469429-3

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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Sampson, Joshua N. ; Wheeler, William A. ; Yeager, Meredith ; [et al.]

Oxford University Press (OUP) ; 2015

In: Journal of the National Cancer Institute Vol. 107, No. 12 ( 2015-12), p. djv279-

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In: Journal of the National Cancer Institute, Oxford University Press (OUP), Vol. 107, No. 12 ( 2015-12), p. djv279-

Type of Medium: Online Resource

ISSN: 0027-8874 , 1460-2105

URL: Article

DOI: 10.1093/jnci/djv279

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Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2015

detail.hit.zdb_id: 2992-0

detail.hit.zdb_id: 1465951-7

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Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

Allen, Naomi E. ; Appleby, Paul N. ; Key, Timothy J. ; [et al.]

Wiley ; 2013

In: International Journal of Cancer Vol. 132, No. 3 ( 2013-02-01), p. 635-644

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In: International Journal of Cancer, Wiley, Vol. 132, No. 3 ( 2013-02-01), p. 635-644

Type of Medium: Online Resource

ISSN: 0020-7136

URL: Issue

URL: Article

DOI: 10.1002/ijc.v132.3

DOI: 10.1002/ijc.27643

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Language: English

Publisher: Wiley

Publication Date: 2013

detail.hit.zdb_id: 218257-9

detail.hit.zdb_id: 1474822-8

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Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora‐Ros, Raul ; Béraud, Virginie ; Franceschi, Silvia ; [et al.]

Wiley ; 2018

In: International Journal of Cancer Vol. 142, No. 3 ( 2018-02), p. 449-459

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In: International Journal of Cancer, Wiley, Vol. 142, No. 3 ( 2018-02), p. 449-459

Abstract: What's new? The message is ubiquitous: to stay healthy, eat a diet rich in fruits and vegetables. But some cancers remain undeterred by a colorful diet. In this paper, the authors sought an association between thyroid cancer risk and consumption of fruit and vegetables. They used data from the EPIC cohort, which includes over half a million individuals with a wide range of dietary habits. Their analysis revealed no difference in risk attributable to total fruit and vegetable consumption, or consumption of any individual fruit or vegetable.

Type of Medium: Online Resource

ISSN: 0020-7136 , 1097-0215

URL: Issue

URL: Article

DOI: 10.1002/ijc.v142.3

DOI: 10.1002/ijc.30880

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XA 10000

Language: English

Publisher: Wiley

Publication Date: 2018

detail.hit.zdb_id: 218257-9

detail.hit.zdb_id: 1474822-8

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Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Cust, Anne E ; Kaaks, Rudolf ; Friedenreich, Christine ; [et al.]

Bioscientifica ; 2007

In: Endocrine-Related Cancer Vol. 14, No. 3 ( 2007-09), p. 755-767

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In: Endocrine-Related Cancer, Bioscientifica, Vol. 14, No. 3 ( 2007-09), p. 755-767

Abstract: To clarify the role of metabolic factors in endometrial carcinogenesis, we conducted a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), and examined the relation between prediagnostic plasma lipids, lipoproteins, and glucose, the metabolic syndrome (MetS; a cluster of metabolic factors) and endometrial cancer risk. Among pre- and postmenopausal women, 284 women developed endometrial cancer during follow-up. Using risk set sampling, 546 matched control subjects were selected. From conditional logistic regression models, high-density lipoprotein cholesterol (HDL-C) levels were inversely associated with risk body mass index (BMI)-adjusted relative risk (RR) for top versus bottom quartile 0.61 (95% confidence intervals (CI) 0.38–0.97), P trend = 0.02). Glucose levels were positively associated with risk (BMI-adjusted RR top versus bottom quartile 1.69 (95% CI 0.99–2.90), P trend = 0.03), which appeared stronger among postmenopausal women (BMI-adjusted RR top versus bottom tertile 2.61 (95% CI 1.46–4.66), P trend = 0.0006, P heterogeneity = 0.13) and never-users of exogenous hormones ( P heterogeneity = 0.005 for oral contraceptive (OC) use and 0.05 for hormone replacement therapy-use). The associations of HDL-C and glucose with risk were no longer statistically significant after further adjustment for obesity-related hormones. Plasma total cholesterol, Low-density lipoprotein cholesterol (LDL-C), and triglycerides were not significantly related to overall risk. The presence of MetS was associated with risk (RR 2.12 (95% CI 1.51–2.97)), which increased with the number of MetS factors ( P trend = 0.02). An increasing number of MetS factors other than waist circumference, however, was marginally significantly associated with risk only in women with waist circumference above the median ( P interaction = 0.01). None of the associations differed significantly by fasting status. These findings suggest that metabolic abnormalities and obesity may act synergistically to increase endometrial cancer risk.

Type of Medium: Online Resource

ISSN: 1351-0088 , 1479-6821

URL: Article

DOI: 10.1677/ERC-07-0132

Language: Unknown

Publisher: Bioscientifica

Publication Date: 2007

detail.hit.zdb_id: 2010895-3

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Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Rohrmann, Sabine ; Overvad, Kim ; Bueno-de-Mesquita, H Bas ; [et al.]

Springer Science and Business Media LLC ; 2013

In: BMC Medicine Vol. 11, No. 1 ( 2013-12)

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In: BMC Medicine, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2013-12)

Type of Medium: Online Resource

ISSN: 1741-7015

URL: Article

DOI: 10.1186/1741-7015-11-63

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 2131669-7

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Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium

Cook, Michael B ; Barnett, Matthew J ; Bock, Cathryn H ; [et al.]

BMJ ; 2019

In: Gut Vol. 68, No. 6 ( 2019-06), p. 960-968

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In: Gut, BMJ, Vol. 68, No. 6 ( 2019-06), p. 960-968

Abstract: Cross-sectional data indicate that systemic inflammation is important in oesophageal adenocarcinoma. We conducted a prospective study to assess whether prediagnostic circulating markers of inflammation were associated with oesophageal adenocarcinoma and to what extent they mediated associations of obesity and cigarette smoking with cancer risk. Design This nested case–control study included 296 oesophageal adenocarcinoma cases and 296 incidence density matched controls from seven prospective cohort studies. We quantitated 69 circulating inflammation markers using Luminex-based multiplex assays. Conditional logistic regression models estimated associations between inflammation markers and oesophageal adenocarcinoma, as well as direct and indirect effects of obesity and smoking on risk of malignancy. Results Soluble tumour necrosis factor receptor 2 (sTNFR2) (ORs quartile 4 vs 1 =2.67, 95% CI 1.52 to 4.68) was significantly associated with oesophageal adenocarcinoma. Additional markers close to the adjusted significance threshold included C reactive protein, serum amyloid A, lipocalin-2, resistin, interleukin (IL) 3, IL17A, soluble IL-6 receptor and soluble vascular endothelial growth factor receptor 3. Adjustment for body mass index, waist circumference or smoking status slightly attenuated biomarker–cancer associations. Mediation analysis indicated that sTNFR2 may account for 33% (p=0.005) of the effect of waist circumference on oesophageal adenocarcinoma risk. Resistin, plasminogen activator inhibitor 1, C reactive protein and serum amyloid A were also identified as potential mediators of obesity–oesophageal adenocarcinoma associations. For smoking status, only plasminogen activator inhibitor 1 was a nominally statistically significant (p 〈 0.05) mediator of cancer risk. Conclusion This prospective study provides evidence of a link between systemic inflammation and oesophageal adenocarcinoma risk. In addition, this study provides the first evidence that indirect effects of excess adiposity and cigarette smoking, via systemic inflammation, increase the risk of oesophageal adenocarcinoma.

Type of Medium: Online Resource

ISSN: 0017-5749 , 1468-3288

URL: Article

DOI: 10.1136/gutjnl-2018-316678

DOI: 10.1136/gutjnl-2018-316678.supp1

DOI: 10.1136/gutjnl-2018-316678.supp2

DOI: 10.1136/gutjnl-2018-316678.supp3

DOI: 10.1136/gutjnl-2018-316678.supp4

DOI: 10.1136/gutjnl-2018-316678.supp9

DOI: 10.1136/gutjnl-2018-316678.supp5

DOI: 10.1136/gutjnl-2018-316678.supp6

DOI: 10.1136/gutjnl-2018-316678.supp7

DOI: 10.1136/gutjnl-2018-316678.supp8

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Language: English

Publisher: BMJ

Publication Date: 2019

detail.hit.zdb_id: 1492637-4

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Folate and alcohol intakes: Related or independent roles in the adenoma‐carcinoma sequence?

Boutron‐Ruault, Marie‐Christine ; Senesse, Pierre ; Faivre, Jean ; [et al.]

Informa UK Limited ; 1996

In: Nutrition and Cancer Vol. 26, No. 3 ( 1996-01), p. 337-346

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In: Nutrition and Cancer, Informa UK Limited, Vol. 26, No. 3 ( 1996-01), p. 337-346

Type of Medium: Online Resource

ISSN: 0163-5581 , 1532-7914

URL: Article

DOI: 10.1080/01635589609514489

Language: English

Publisher: Informa UK Limited

Publication Date: 1996

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