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Metabolic Characterization of Primary Rat Hepatocytes Cultivated in Parallel Microfluidic Biochips

Legendre, Audrey ; Baudoin, Régis ; Alberto, Giulia ; [et al.]

Elsevier BV ; 2013

In: Journal of Pharmaceutical Sciences Vol. 102, No. 9 ( 2013-09), p. 3264-3276

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In: Journal of Pharmaceutical Sciences, Elsevier BV, Vol. 102, No. 9 ( 2013-09), p. 3264-3276

Type of Medium: Online Resource

ISSN: 0022-3549

URL: Article

DOI: 10.1002/jps.23466

Language: English

Publisher: Elsevier BV

Publication Date: 2013

detail.hit.zdb_id: 1491821-3

SSG: 15,3

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Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans

Rotival, Maxime ; Zeller, Tanja ; Wild, Philipp S. ; [et al.]

Public Library of Science (PLoS) ; 2011

In: PLoS Genetics Vol. 7, No. 12 ( 2011-12-1), p. e1002367-

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In: PLoS Genetics, Public Library of Science (PLoS), Vol. 7, No. 12 ( 2011-12-1), p. e1002367-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1002367

DOI: 10.1371/journal.pgen.1002367.g001

DOI: 10.1371/journal.pgen.1002367.g002

DOI: 10.1371/journal.pgen.1002367.g003

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DOI: 10.1371/journal.pgen.1002367.s001

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DOI: 10.1371/journal.pgen.1002367.s003

DOI: 10.1371/journal.pgen.1002367.s004

DOI: 10.1371/journal.pgen.1002367.s005

DOI: 10.1371/journal.pgen.1002367.s006

DOI: 10.1371/journal.pgen.1002367.s007

DOI: 10.1371/journal.pgen.1002367.s008

DOI: 10.1371/journal.pgen.1002367.s009

DOI: 10.1371/journal.pgen.1002367.s010

DOI: 10.1371/journal.pgen.1002367.s011

DOI: 10.1371/journal.pgen.1002367.s012

DOI: 10.1371/journal.pgen.1002367.s013

DOI: 10.1371/journal.pgen.1002367.s014

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2011

detail.hit.zdb_id: 2186725-2

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Critical Role of cRel Subunit of NF-κB in Sepsis Survival

Courtine, Emilie ; Pène, Frédéric ; Cagnard, Nicolas ; [et al.]

American Society for Microbiology ; 2011

In: Infection and Immunity Vol. 79, No. 5 ( 2011-05), p. 1848-1854

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In: Infection and Immunity, American Society for Microbiology, Vol. 79, No. 5 ( 2011-05), p. 1848-1854

Abstract: NF-κB is a critical regulator of gene expression during severe infections. NF-κB comprises homo- and heterodimers of proteins from the Rel family. Among them, p50 and p65 have been clearly implicated in the pathophysiology of sepsis. In contrast, the role of cRel in sepsis is still controversial and has been poorly studied in single-pathogen infections. We aimed to investigate the consequences of cRel deficiency in a cecal ligation and puncture (CLP) model of sepsis. We have approached the underlying mechanisms of host defense by analyzing bacterial clearance, systemic inflammation, and the distribution of spleen dendritic cell subsets. Moreover, by using a genome-wide technology, we have also analyzed the CLP-induced modifications in gene expression profiles both in wild-type (wt) and in rel −/− mice. The absence of cRel enhances mortality due to polymicrobial sepsis. Despite normal pathogen clearance, cRel deficiency leads to an altered systemic inflammatory response associated with a sustained loss of the spleen lymphoid dendritic cells. Furthermore, a whole-blood microarray study reveals that the differential outcome between wt and rel −/− mice during sepsis is preceded by remarkable changes in the expression of hundreds of genes involved in aspects of host-pathogen interaction, such as host survival and lipid metabolism. In conclusion, cRel is a key NF-κB member required for host antimicrobial defenses and a regulatory transcription subunit that controls the inflammatory and immune responses in severe infection.

Type of Medium: Online Resource

ISSN: 0019-9567 , 1098-5522

URL: Article

DOI: 10.1128/IAI.00021-11

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2011

detail.hit.zdb_id: 1483247-1

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Genome-Wide Haplotype Analysis of Cis Expression Quantitative Trait Loci in Monocytes

Garnier, Sophie ; Truong, Vinh ; Brocheton, Jessy ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS Genetics Vol. 9, No. 1 ( 2013-1-31), p. e1003240-

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In: PLoS Genetics, Public Library of Science (PLoS), Vol. 9, No. 1 ( 2013-1-31), p. e1003240-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1003240

DOI: 10.1371/journal.pgen.1003240.g001

DOI: 10.1371/journal.pgen.1003240.g002

DOI: 10.1371/journal.pgen.1003240.g003

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DOI: 10.1371/journal.pgen.1003240.g005

DOI: 10.1371/journal.pgen.1003240.g006

DOI: 10.1371/journal.pgen.1003240.s001

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DOI: 10.1371/journal.pgen.1003240.s003

DOI: 10.1371/journal.pgen.1003240.s004

DOI: 10.1371/journal.pgen.1003240.s005

DOI: 10.1371/journal.pgen.1003240.s006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2186725-2

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A Follow-Up Study of a Genome-wide Association Scan Identifies a Susceptibility Locus for Venous Thrombosis on Chromosome 6p24.1

Morange, Pierre-Emmanuel ; Bezemer, Irene ; Saut, Noémie ; [et al.]

Elsevier BV ; 2010

In: The American Journal of Human Genetics Vol. 86, No. 4 ( 2010-04), p. 655-

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In: The American Journal of Human Genetics, Elsevier BV, Vol. 86, No. 4 ( 2010-04), p. 655-

Type of Medium: Online Resource

ISSN: 0002-9297

URL: Article

DOI: 10.1016/j.ajhg.2010.03.013

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2010

detail.hit.zdb_id: 1473813-2

SSG: 12

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Gene Expression Signature in Peripheral Blood Cells Detects Intracranial Aneurysm : 913

Yilmaz, Saliha ; Bijlenga, Philippe ; Rashid, Mamunur ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2010

In: Neurosurgery Vol. 67, No. 2 ( 2010-08), p. 540-

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In: Neurosurgery, Ovid Technologies (Wolters Kluwer Health), Vol. 67, No. 2 ( 2010-08), p. 540-

Type of Medium: Online Resource

ISSN: 0148-396X

URL: Article

DOI: 10.1227/01.NEU.0000386985.32689.26

RVK:

XA 10000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2010

detail.hit.zdb_id: 1491894-8

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A Follow-Up Study of a Genome-wide Association Scan Identifies a Susceptibility Locus for Venous Thrombosis on Chromosome 6p24.1

Morange, Pierre-Emmanuel ; Bezemer, Irene ; Saut, Noémie ; [et al.]

Elsevier BV ; 2010

In: The American Journal of Human Genetics Vol. 86, No. 4 ( 2010-04), p. 592-595

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In: The American Journal of Human Genetics, Elsevier BV, Vol. 86, No. 4 ( 2010-04), p. 592-595

Type of Medium: Online Resource

ISSN: 0002-9297

URL: Article

DOI: 10.1016/j.ajhg.2010.02.011

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2010

detail.hit.zdb_id: 1473813-2

SSG: 12

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Correction: Comprehensive Exploration of the Effects of miRNA SNPs on Monocyte Gene Expression

Greliche, Nicolas ; Zeller, Tanja ; Wild, Philipp S. ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS ONE Vol. 7, No. 10 ( 2012-10-5)

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 10 ( 2012-10-5)

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/annotation/bd5c0312-c902-4065-be2b-385fcf70c125

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2267670-3

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Powerful Identification of Cis-regulatory SNPs in Human Primary Monocytes Using Allele-Specific Gene Expression

Almlöf, Jonas Carlsson ; Lundmark, Per ; Lundmark, Anders ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS ONE Vol. 7, No. 12 ( 2012-12-26), p. e52260-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 12 ( 2012-12-26), p. e52260-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0052260

DOI: 10.1371/journal.pone.0052260.g001

DOI: 10.1371/journal.pone.0052260.g002

DOI: 10.1371/journal.pone.0052260.t001

DOI: 10.1371/journal.pone.0052260.s001

DOI: 10.1371/journal.pone.0052260.s002

DOI: 10.1371/journal.pone.0052260.s003

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2267670-3

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Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Baudoin, Régis ; Prot, Jean Matthieu ; Nicolas, Grégory ; [et al.]

Informa UK Limited ; 2013

In: Xenobiotica Vol. 43, No. 2 ( 2013-02), p. 140-152

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In: Xenobiotica, Informa UK Limited, Vol. 43, No. 2 ( 2013-02), p. 140-152

Type of Medium: Online Resource

ISSN: 0049-8254 , 1366-5928

URL: Article

DOI: 10.3109/00498254.2012.706725

Language: English

Publisher: Informa UK Limited

Publication Date: 2013

detail.hit.zdb_id: 1485113-1

SSG: 12

SSG: 15,3

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