In:
European Journal of Haematology, Wiley, Vol. 95, No. 5 ( 2015-11), p. 442-448
Abstract:
Diffuse large B‐cell lymphoma ( DLBCL ) is an aggressive subtype of non‐Hodgkin lymphoma ( NHL ) and is the most common NHL subtype diagnosed worldwide. The first large‐scale genome‐wide association study ( GWAS ) of DLBCL with over 4000 cases conducted among individuals of European ancestry recently identified five independent SNP s that achieved genome‐wide significance, and two SNP s that showed a suggestive association with DLBCL risk. Methods To evaluate whether Eastern Asians and individuals of European ancestry share similar genetic risk factors for this disease, we attempted to replicate these GWAS findings in a pooled series of 1124 DLBCL cases and 3596 controls from Hong Kong, South Korea, and Thailand. Results Three of the five genome‐wide significant SNP s from the DLBCL GWAS were significantly associated with DLBCL in our study population, including the top finding from the GWAS , EXOC 2 rs116446171, which achieved genome‐wide significance in our data (per allele OR = 2.04, 95% CI = 1.63–2.56; p trend = 3.9 × 10 −10 ). Additionally, we observed a significant association with PVT 1 rs13255292 (per allele OR = 1.34, 95% CI = 1.19–1.52; p trend = 2.1 × 10 −6 ), which was the second strongest finding in the GWAS , and with HLA ‐B rs2523607 (per allele OR = 3.05, 95% CI = 1.32–7.05; p trend = 0.009). Conclusions Our study, which provides the first evaluation in Eastern Asians of SNP s definitively associated with DLBCL risk in individuals of European ancestry, indicates that at least some of the genetic factors associated with risk of DLBCL are similar between these populations.
Type of Medium:
Online Resource
ISSN:
0902-4441
,
1600-0609
DOI:
10.1111/ejh.2015.95.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2027114-1
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