In:
PLOS Biology, Public Library of Science (PLoS), Vol. 20, No. 4 ( 2022-4-27), p. e3001615-
Abstract:
Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process of evolutionary specialization in eutherian mammals resulting in the emergence of a novel placental function for the gene. Mbnl3 belongs to a family of RNA-binding proteins whose members regulate multiple aspects of RNA metabolism. We find that, in eutherians, while both Mbnl3 and its paralog Mbnl2 are strongly expressed in placenta, Mbnl3 expression has been lost from nonplacental tissues in association with the evolution of a novel promoter. Moreover, Mbnl3 has undergone accelerated protein sequence evolution leading to changes in its RNA-binding specificities and cellular localization. While Mbnl2 and Mbnl3 share partially redundant roles in regulating alternative splicing, polyadenylation site usage and, in turn, placenta maturation, Mbnl3 has also acquired novel biological functions. Specifically, Mbnl3 knockout (M3KO) alone results in increased placental growth associated with higher Myc expression. Furthermore, Mbnl3 loss increases fetal resource allocation during limiting conditions, suggesting that location of Mbnl3 on the X chromosome has led to its role in limiting placental growth, favoring the maternal side of the parental genetic conflict.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001615
DOI:
10.1371/journal.pbio.3001615.g001
DOI:
10.1371/journal.pbio.3001615.g002
DOI:
10.1371/journal.pbio.3001615.g003
DOI:
10.1371/journal.pbio.3001615.g004
DOI:
10.1371/journal.pbio.3001615.g005
DOI:
10.1371/journal.pbio.3001615.s001
DOI:
10.1371/journal.pbio.3001615.s002
DOI:
10.1371/journal.pbio.3001615.s003
DOI:
10.1371/journal.pbio.3001615.s004
DOI:
10.1371/journal.pbio.3001615.s005
DOI:
10.1371/journal.pbio.3001615.s006
DOI:
10.1371/journal.pbio.3001615.s007
DOI:
10.1371/journal.pbio.3001615.s008
DOI:
10.1371/journal.pbio.3001615.s009
DOI:
10.1371/journal.pbio.3001615.s010
DOI:
10.1371/journal.pbio.3001615.s011
DOI:
10.1371/journal.pbio.3001615.s012
DOI:
10.1371/journal.pbio.3001615.s013
DOI:
10.1371/journal.pbio.3001615.s014
DOI:
10.1371/journal.pbio.3001615.s015
DOI:
10.1371/journal.pbio.3001615.s016
DOI:
10.1371/journal.pbio.3001615.s017
DOI:
10.1371/journal.pbio.3001615.s018
DOI:
10.1371/journal.pbio.3001615.s019
DOI:
10.1371/journal.pbio.3001615.s020
DOI:
10.1371/journal.pbio.3001615.s021
DOI:
10.1371/journal.pbio.3001615.s022
DOI:
10.1371/journal.pbio.3001615.s023
DOI:
10.1371/journal.pbio.3001615.s024
DOI:
10.1371/journal.pbio.3001615.s025
DOI:
10.1371/journal.pbio.3001615.s026
DOI:
10.1371/journal.pbio.3001615.s027
DOI:
10.1371/journal.pbio.3001615.s028
DOI:
10.1371/journal.pbio.3001615.r001
DOI:
10.1371/journal.pbio.3001615.r002
DOI:
10.1371/journal.pbio.3001615.r003
DOI:
10.1371/journal.pbio.3001615.r004
DOI:
10.1371/journal.pbio.3001615.r005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2126773-X
Bookmarklink