In:
bchm, Walter de Gruyter GmbH, Vol. 394, No. 7 ( 2013-7-1), p. 819-829
Abstract:
Tissue factor (TF), an initiator of blood coagulation in vivo , is expressed in a variety of cells. Sufficient natural TF has been isolated to clone and express recombinant proteins ranging from full-length TF to its extracellular domain. Because of the limited availability of natural TF, recombinant proteins have been used as surrogates. Despite the differences in their post-translational modifications, it has been accepted that membrane-anchored recombinant TFs are quite similar to the natural TF. Recent studies, however, have shown that post-translational modifications play an important role in TF-triggered thrombin generation.
Type of Medium:
Online Resource
ISSN:
1437-4315
,
1431-6730
DOI:
10.1515/hsz-2012-0350
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2013
detail.hit.zdb_id:
1466062-3
SSG:
12
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