In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2022-3-30), p. e0265143-
Abstract:
This study aimed to evaluate the quality of low-dose-rate (LDR) prostate brachytherapy (BT) based on treatment-related dosimetric outcomes. Data of 100 patients treated using LDR BT with stranded seeds from November 2012 to November 2017 were collected. The prescription dose for the prostate was 145 Gy. The dose constraints for the preoperative plan were: V100% ≥ 95%, V150% ≤ 60%, V200% ≤ 20% for the prostate; V100% for rectum, ≤ 1 cc; and V200 Gy for urethra, 0.0 cc. Intraoperative real-time dose calculation and postoperative dose distribution analysis on days 0 and 30 were performed. Median dosimetric outcomes on days 0 and 30 respective were: V100% 92.28% and 92.23%, V200% 18.63% and 25.02%, and D90% 150.88 Gy and 151.46 Gy for the prostate; V100% for the rectum, 0.11 cc and 0.22 cc; and V200 Gy for the urethra, 0.00 cc and 0.00 cc, respectively. Twenty patients underwent additional seed implantation to compensate for insufficient dose coverage of the prostate. No loss or substantial migration of seeds or severe toxicity was reported. With stranded seed implantation and intraoperative optimization, appropriate dose delivery to the prostate without excessive dose to the organs at risk could be achieved.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0265143
DOI:
10.1371/journal.pone.0265143.g001
DOI:
10.1371/journal.pone.0265143.g002
DOI:
10.1371/journal.pone.0265143.g003
DOI:
10.1371/journal.pone.0265143.g004
DOI:
10.1371/journal.pone.0265143.g005
DOI:
10.1371/journal.pone.0265143.g006
DOI:
10.1371/journal.pone.0265143.g007
DOI:
10.1371/journal.pone.0265143.g008
DOI:
10.1371/journal.pone.0265143.t001
DOI:
10.1371/journal.pone.0265143.t002
DOI:
10.1371/journal.pone.0265143.s001
DOI:
10.1371/journal.pone.0265143.s002
DOI:
10.1371/journal.pone.0265143.s003
DOI:
10.1371/journal.pone.0265143.r001
DOI:
10.1371/journal.pone.0265143.r002
DOI:
10.1371/journal.pone.0265143.r003
DOI:
10.1371/journal.pone.0265143.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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