In:
Journal of the International Neuropsychological Society, Cambridge University Press (CUP), Vol. 5, No. 6 ( 1999-09), p. 502-509
Abstract:
The Clock Drawing Test (CDT) is widely used in
the assessment of dementia and is known to be sensitive to the detection of deficits in neurodegenerative disorders
such as Alzheimer's disease (AD). CDT performance is dependent not only on visuospatial and constructional
abilities, but also on conceptual and executive functioning; therefore, it is likely to be mediated by multiple brain
regions. The purpose of the present study was to identify component cognitive processes and regional cortical volumes
that contribute to CDT performance in AD. In 29 patients with probable AD, CDT performance was significantly related
to right-, but not left-hemisphere, regional gray matter volume. Specifically, CDT score correlated significantly
with the right anterior and posterior superior temporal lobe volumes. CDT scores showed significant relationships
with tests of semantic knowledge, executive function, and visuoconstruction, and receptive language. These results
suggest that in AD patients, CDT performance is attributable to impairment in multiple cognitive domains but is related
specifically to regional volume loss of right temporal cortex. ( JINS , 1999, 5 , 502–509.)
Type of Medium:
Online Resource
ISSN:
1355-6177
,
1469-7661
DOI:
10.1017/S1355617799566034
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
1999
detail.hit.zdb_id:
2000018-2
SSG:
5,2
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