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  • 1
    Online Resource
    Online Resource
    Intraoperative Findings of Inferior Petrosal Vein During Microvascular Decompression for Hemifacial Spasm: A Single-Surgeon Experience
    Frontiers Media SA ; 2022
    In:  Frontiers in Surgery Vol. 9 ( 2022-6-10)
    Details
    In: Frontiers in Surgery, Frontiers Media SA, Vol. 9 ( 2022-6-10)
    Abstract: This study aims to evaluate the impact of the inferior petrosal veins (IPVs) on operational exploration and to analyze related anatomic features. Methods A total of 317 patients were retrospectively studied. Surgical outcomes and postoperative complications were analyzed, and patients were divided into two groups according to whether the IPV was sacrificed or preserved. The diameter of the IPV was also recorded during operation. Furthermore, the position where the IPV drained into the jugular bulb was recorded in each patient, and the influence of different injection points on the operation was analyzed. Results IPVs were conclusively identified in 242/317 (76.3%) of patients, with 110/242 (45.5%) of patients categorized as “IPV sacrifice” versus 132/242 (54.5%) categorized as “IPV preservation.” IPV diameter was observed to be & lt;0.5 mm in 58 cases (23.9%), 0.5 mm–1.0 mm (≥0.5 mm and ≤1.0 mm) in 145 cases (59.9%), and & gt;1 mm in 39 cases (16.2%). The position of IPV drainage into the jugular bulb was at the level of the accessory nerve in 163 cases (67.3%), the level of the vagus nerve in 42 cases (17.4%), and the level of the glossopharyngeal nerve or above in 37 cases (15.3%). The diameters of IPV in the sacrifice group were mainly less than 1 mm (94.5% vs. 75%, P  & lt; 0.01), and the cases with draining points near the glossopharyngeal nerve were more than that in the preservation group (27.3% vs. 5.3%, P   & lt; 0.01). Conclusion IPV is an obstructive structure in MVD for HFS, with considerable variations in diameters and draining points. IPV near the glossopharyngeal nerve significantly impacts surgical exposure and is often sacrificed for a better view of the operation field. Meanwhile, it is feasible to maintain IPVs with a diameter & gt;1 mm.
    Type of Medium: Online Resource
    ISSN: 2296-875X
    URL: Article
    DOI: 10.3389/fsurg.2022.921589
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2773823-1
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  • 2
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    Image_6.TIF
    Frontiers Media SA ; 2021
    In:  Frontiers in Cell and Developmental Biology Vol. 9 ( 2021-8-23)
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    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-8-23)
    Abstract: A group of circulating microRNAs (miRNAs) have been implicated in the pathogenesis of Parkinson’s disease. However, a comprehensive study of the interactions between pathogenic miRNAs and their downstream Parkinson’s disease (PD)-related target genes has not been performed. Here, we identified the miRNA expression profiles in the plasma and circulating exosomes of Parkinson’s disease patients using next-generation RNA sequencing. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses showed that the miRNA target genes were enriched in axon guidance, neurotrophin signaling, cellular senescence, and the Transforming growth factor-β (TGF-β), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) and mechanistic target of rapamycin (mTOR) signaling pathways. Furthermore, a group of aberrantly expressed miRNAs were selected and further validated in individual patient plasma, human neural stem cells (NSCs) and a rat model of PD. More importantly, the full scope of the regulatory network between these miRNAs and their PD-related gene targets in human neural stem cells was examined, and the findings revealed a similar but still varied downstream regulatory cascade involving many known PD-associated genes. Additionally, miR-23b-3p was identified as a novel direct regulator of alpha-synuclein, which is possibly the key component in PD. Our current study, for the first time, provides a glimpse into the regulatory network of pathogenic miRNAs and their PD-related gene targets in PD. Moreover, these PD-associated miRNAs may serve as biomarkers and novel therapeutic targets for PD.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fcell.2021.695007
    DOI: 10.3389/fcell.2021.695007.s001
    DOI: 10.3389/fcell.2021.695007.s002
    DOI: 10.3389/fcell.2021.695007.s003
    DOI: 10.3389/fcell.2021.695007.s004
    DOI: 10.3389/fcell.2021.695007.s005
    DOI: 10.3389/fcell.2021.695007.s006
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2737824-X
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  • 3
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    Image_6.tif
    Frontiers Media SA ; 2023
    In:  Frontiers in Endocrinology Vol. 14 ( 2023-4-5)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 14 ( 2023-4-5)
    Abstract: Gliomas are the most common intracranial nervous system tumours that are highly malignant and aggressive, and mitochondria are an important marker of metabolic reprogramming of tumour cells, the prognosis of which cannot be accurately predicted by current histopathology. Therefore, Identify a mitochondrial gene with immune-related features that could be used to predict the prognosis of glioma patients. Methods Gliomas data were downloaded from the TCGA database and mitochondrial-associated genes were obtained from the MITOCARTA 3.0 dataset. The CGGA, kamoun and gravendeel databases were used as external datasets. LASSO(Least absolute shrinkage and selection operator) regression was applied to identify prognostic features, and area and nomograms under the ROC(Receiver Operating Characteristic) curve were used to assess the robustness of the model. Single sample genomic enrichment analysis (ssGSEA) was employed to explore the relationship between model genes and immune infiltration, and drug sensitivity was used to identify targeting drugs. Cellular studies were then performed to demonstrate drug killing against tumours. Results COX assembly mitochondrial protein homolog ( CMC1 ), Cytochrome c oxidase protein 20 homolog ( COX20 ) and Cytochrome b-c1 complex subunit 7 ( UQCRB ) were identified as prognostic key genes in glioma, with UQCRB , CMC1 progressively increasing and COX20 progressively decreasing with decreasing risk scores. ROC curve analysis of the TCGA training set model yielded AUC (Area Under The Curve) values & gt;0.8 for 1-, 2- and 3-year survival, and the model was associated with both CD8+ T cells and immune checkpoints. Finally, using cellMiner database and molecular docking, it was confirmed that UQCRB binds covalently to Amonafide via lysine at position 78 and threonine at position 82, while cellular assays showed that Amonafide inhibits glioma migration and invasion. Conclusion Our three mitochondrial genomic composition-related features accurately predict Survival in glioma patients, and we also provide glioma chemotherapeutic agents that may be mitochondria-related targets.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fendo.2023.1172182
    DOI: 10.3389/fendo.2023.1172182.s001
    DOI: 10.3389/fendo.2023.1172182.s002
    DOI: 10.3389/fendo.2023.1172182.s003
    DOI: 10.3389/fendo.2023.1172182.s004
    DOI: 10.3389/fendo.2023.1172182.s005
    DOI: 10.3389/fendo.2023.1172182.s006
    DOI: 10.3389/fendo.2023.1172182.s007
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2592084-4
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  • 4
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    Online Resource
    Study on the relationship between obesity and complications of Pediatric Epilepsy surgery
    Springer Science and Business Media LLC ; 2023
    In:  BMC Pediatrics Vol. 23, No. 1 ( 2023-03-30)
    Details
    In: BMC Pediatrics, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-03-30)
    Abstract: Studies have shown that obesity has a significant impact on poor surgical outcomes. However, the relationship between obesity and pediatric epilepsy surgery has not been reported. This study aimed to explore the relationship between obesity and complications of pediatric epilepsy surgery and the effect of obesity on the outcome of pediatric epilepsy surgery, and to provide a reference for weight management of children with epilepsy. Methods A single-center retrospective analysis of complications in children undergoing epilepsy surgery was conducted. Body mass index (BMI) percentiles were adjusted by age and used as a criterion for assessing obesity in children. According to the adjusted BMI value, the children were divided into the obese group (n = 16) and nonobese group (n = 20). The intraoperative blood loss, operation time, and postoperative fever were compared between the two groups. Results A total of 36 children were included in the study, including 20 girls and 16 boys. The mean age of the children was 8.0 years old, ranging from 0.8 to 16.9 years old. The mean BMI was 18.1 kg/m2 , ranging from 12.4 kg/m2 to 28.3 kg/m2 . Sixteen of them were overweight or obese (44.4%). Obesity was associated with higher intraoperative blood loss in children with epilepsy (p = 0.04), and there was no correlation between obesity and operation time (p = 0.21). Obese children had a greater risk of postoperative fever (56.3%) than nonobese children (55.0%), but this was statistically nonsignificant (p = 0.61). The long-term follow-up outcomes showed that 23 patients (63.9%) were seizure-free (Engel grade I), 6 patients (16.7%) had Engel grade II, and 7 patients (19.4%) had Engel grade III. There was no difference in long-term seizure control outcomes between obese and nonobese groups (p = 0.682). There were no permanent neurological complications after surgery. Conclusion Compared with nonobese children with epilepsy, obese children with epilepsy had a higher intraoperative blood loss. It is necessary to conduct early weight management of children with epilepsy as long as possible.
    Type of Medium: Online Resource
    ISSN: 1471-2431
    URL: Article
    DOI: 10.1186/s12887-023-03948-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041342-7
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  • 5
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    Online Resource
    The Differences in Colonic Mucosal Microbiota Between Normal Individual and Colon Cancer Patients by Polymerase Chain Reaction-denaturing Gradient Gel Electrophoresis
    Ovid Technologies (Wolters Kluwer Health) ; 2014
    In:  Journal of Clinical Gastroenterology Vol. 48, No. 2 ( 2014-02), p. 138-144
    Details
    In: Journal of Clinical Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 48, No. 2 ( 2014-02), p. 138-144
    Type of Medium: Online Resource
    ISSN: 0192-0790
    URL: Article
    DOI: 10.1097/MCG.0b013e3182a26719
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2014
    detail.hit.zdb_id: 2041558-8
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  • 6
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    Effect of moisture content during preparation on the physicochemical properties of pellets made from different biomass materials
    BioResources ; 2019
    In:  BioResources Vol. 15, No. 1 ( 2019-12-3), p. 557-573
    Details
    In: BioResources, BioResources, Vol. 15, No. 1 ( 2019-12-3), p. 557-573
    Abstract: The influence of moisture content was investigated relative to the pellet forming process and the pellet properties. Three different types of raw biomass (pine sawdust, corn straw, and peanut shell) were pelletized by hot pressing at different moisture levels (12%, 14%, and 16%) in a pellet mill with horizontal and ring type dies to investigate its physical property indexes of durability, pellet density, and combustion performance. The results of the study showed that pellet density and heating value were related to the moisture content. The maximum pellet density of the fuel pellets of sawdust, corn straw, and peanut shells was 1180 kg/m3, 1220 kg/m3, and 1130 kg/m3, respectively. The drop resistance and deformation resistance of pine sawdust and corn straw decreased with increased moisture content, but peanut shell initially increased with the increase of moisture before decreasing. The comprehensive combustion index of corn straw (14.03) was the highest during the combustion performance analysis in comparison to sawdust (11.10) and peanut shell (10.00). Overall, the optimal moisture content of sawdust, corn straw, and peanut shell was 12%, 12%, and 14%, respectively, and the combustion performance of the pellets made from corn straw was superior compared to the other two feedstocks.
    Type of Medium: Online Resource
    ISSN: 1930-2126 , 1930-2126
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.15376/biores.15.1
    DOI: 10.15376/biores
    DOI: 10.15376/biores.15.1.557-573
    Language: English
    Publisher: BioResources
    Publication Date: 2019
    detail.hit.zdb_id: 2238238-0
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  • 7
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    Online Resource
    Comparison of Pelvic Autonomic Nerve Function Recovery Between the Group only with Surgery and Group with Additional Acupuncture and Electrotherapy for Treatment in Patients with Rectal Cancer after Anus-Preserving Operation
    Cognizant, LLC ; 2018
    In:  Acupuncture & Electro-Therapeutics Research Vol. 43, No. 2 ( 2018-06-01), p. 103-118
    Details
    In: Acupuncture & Electro-Therapeutics Research, Cognizant, LLC, Vol. 43, No. 2 ( 2018-06-01), p. 103-118
    Abstract: To investigate acupuncture and electro-acupuncture for the recovery of pelvic autonomic nerve in patients with rectal cancer after anus-preserving operation, 120 patients with rectal cancer had anus-preserving operation at the Department of General Surgery in the Fifth People's Hospital of Shanghai Affiliated to Fudan University. They were enrolled between 1 st October-2015 and 30 th June-2017, and were randomly divided into experimental and control groups (60 each). Patients in experimental group were treated with acupuncture and electro-acupuncture. Patients in control group were treated with levator ani exercise. After early stage therapy of acupuncture and electro-acupuncture, the recovery time of patients bowel sound in experimental group and control group were 52.6±4.9 hours versus 66.3±6.4 hours (t=13.17, P 〈 0.05), the recovery time was reduced by about 20% in experimental group. The first exhaust time were 60.5±5.7 hours versus 70.3±7.1 hours (t=8.337, P 〈 0.05), the recovery time was reduced by about 10%. The catheter removal-time 5.5±1.3 days versus 7.1±1.4 days (t=6.487, P 〈 0.05), the recovery time was reduced by about 20%. After late stage therapy of acupuncture and electro-acupuncture, fecal incontinence Wexner score, anorectal pressure, pelvic-floor electromyography, urodynamic index, male sexual function and quality of Life Questionnaire-Colorectal Cancer 29 (QLQ-CR29) in experimental group were improved about 2 months ahead of time in comparison with those in control group. So, the therapy of acupuncture and electro-acupuncture can promote the functional recovery of pelvic autonomic nerve after anus-preserving operation.
    Type of Medium: Online Resource
    ISSN: 0360-1293
    URL: Article
    DOI: 10.3727/036012918X15353852193131
    Language: English
    Publisher: Cognizant, LLC
    Publication Date: 2018
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  • 8
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    Online Resource
    Effectiveness of concomitant use of green tea and polyethylene glycol in bowel preparation for colonoscopy: a randomized controlled study
    Springer Science and Business Media LLC ; 2020
    In:  BMC Gastroenterology Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Gastroenterology, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Polyethylene glycol solution (PEG) is widely used for bowel preparation prior to colonoscopies. However, patients often exhibited adverse events as nausea, vomit and distention due to its uncomfortable tastes and potential side affects. This study aimed to evaluate the effectiveness and safety of concomitant use of green tea (GT) with PEG in bowel preparation prior to colonoscopy. Methods This was a prospective, randomized controlled study. It was conducted at an outpatient setting of colorectal surgery in a tertiary hospital. Patients aged 18 through 80 who were scheduled to undergo colonoscopy between August 2015 and February 2016 were randomly assigned into two groups, admitting either 2 L-PEG solutions with 1 L GT liquids or 2 L-PEG solutions only for bowel preparation. Admitted doses of PEG solutions, taste evaluation, adverse reactions (nausea and vomiting, distention and abdominal pain) were investigated by questionnaires. The bowel cleanliness of each patient was evaluated according to the Aronchick indicators. Results A total of 116 patients were enrolled in this study (PEG+GT 59, PEG 57). Full compliances were achieved in 93.2% patients of group PEG+GT and 59.6% of group PEG ( p   〈  0.001). Mean Aronchick scale between two groups were 2.0 ± 0.9 versus 2.2 ± 0.7 respectively (PEG+GT vs PEG, p  = 0.296). Rates of adverse events as nausea and vomiting, abdominal pain in bowel preparation were significantly different between two groups (55.9% vs 77.2%, p  = 0.015 and 13.6% vs 33.3%, p  = 0.012). Patients in group PEG+GT who have probabilities to receive repeating colonoscopy had a higher willingness to accept PEG+GT again for bowel preparation, compared with PEG group (94.9% vs 57.9%, p   〈  0.001). Conclusions Concomitant use of green tea and polyethylene glycol may effectively reduce incidence of adverse events, increase compliances, with comparable bowel cleanliness in bowel preparation. Trial registration This trial was retrospectively registered on Feb 1st, 2019 ( ChiCTR1900021178 ).
    Type of Medium: Online Resource
    ISSN: 1471-230X
    URL: Article
    DOI: 10.1186/s12876-020-01220-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2041351-8
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  • 9
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    Cerebral ischemia after treatment of posterior communicating artery aneurysms: clipping versus coiling
    Springer Science and Business Media LLC ; 2022
    In:  BMC Neurology Vol. 22, No. 1 ( 2022-11-17)
    Details
    In: BMC Neurology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-11-17)
    Abstract: This study aimed to compare the incidence of cerebral ischemia and outcomes between surgical clipping and endovascular coiling in patients with posterior communicating artery (PCoA) aneurysms. Methods Clinical and imaging data of patients with at least one PCoA aneurysm who underwent surgical clipping or endovascular coiling in our institution from January 2017 to December 2019 were analyzed. Results Three hundred sixty-three aneurysms in 353 patients were included for analysis, 257 in the clipping group, and 106 in the coiling group. The groups did not differ in terms of baseline characteristics. The incidence of postoperative cerebral ischemia (23.35% vs. 11.32%, p  = 0.029) was higher in the clipping group. The proportion of patients with a modified Rankin Scale score ≥ 2 was significantly higher in the clipping group at discharge (35.80% vs. 15.09%; p   〈  0.05) but not six months after discharge (15.56% vs. 8.49%; p   〉  0.05). In the clipping group, the mean age was significantly higher in patients who developed cerebral ischemia than in those who did not. In the coiling group, modified Fisher grade and incidence of fetal PCoA were significantly higher in patients who developed ischemia. Conclusion The incidence of postoperative cerebral ischemia was higher after PCoA aneurysm clipping than after coiling. The causes and characteristics of postoperative cerebral ischemia after PCoA clipping and coiling are different; therefore, treatment should be selected accordingly.
    Type of Medium: Online Resource
    ISSN: 1471-2377
    URL: Article
    DOI: 10.1186/s12883-022-02962-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041347-6
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  • 10
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    Online Resource
    Autologous bone fragments for skull reconstruction after microvascular decompression
    Springer Science and Business Media LLC ; 2022
    In:  BMC Surgery Vol. 22, No. 1 ( 2022-11-18)
    Details
    In: BMC Surgery, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-11-18)
    Abstract: Various methods are used to reconstruct the skull after microvascular decompression, giving their own advantages and disadvantages. The objective of this study was to evaluate the efficacy of using autologous bone fragments for skull reconstruction after microvascular decompression. Methods The clinical and follow-up data of 145 patients who underwent microvascular decompression and skull reconstruction using autologous bone fragments in our hospital from September 2020 to September 2021 were retrospectively analyzed. Results Three patients (2.06%) had delayed wound healing after surgery and were discharged after wound cleaning. No patient developed postoperative cerebrospinal fluid leakage, incisional dehiscence, or intracranial infection. Eighty-five (58.62%) patients underwent follow-up cranial computed tomography at 1 year postoperatively, showed excellent skull reconstruction. And, the longer the follow-up period, the more satisfactory the cranial repair. Two patients underwent re-operation for recurrence of hemifacial spasm, and intraoperative observation revealed that the initial skull defect was filled with new skull bone. Conclusion The use of autologous bone fragments for skull reconstruction after microvascular decompression is safe and feasible, with few postoperative wound complications and excellent long-term repair results.
    Type of Medium: Online Resource
    ISSN: 1471-2482
    URL: Article
    DOI: 10.1186/s12893-022-01820-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2050442-1
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