In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 11 ( 2022-11-18), p. e0276118-
Abstract:
Advances in medicine and public health mean that people are living longer; however, a significant proportion of that increased lifespan is spent in a prolonged state of declining health and wellbeing which places increasing pressure on medical, health and social services. There is a social and economic need to develop strategies to prevent or delay age-related disease and maintain lifelong health. Several studies have suggested links between the gut microbiome and age-related disease, which if confirmed would present a modifiable target for intervention development. The MOTION study aims to determine whether and how changes in the gut microbiome are associated with physical and mental capacity. A comprehensive longitudinal multiparameter study such as this has not been previously undertaken. Methods MOTION is a longitudinal prospective cohort study with a focus on gut health and cognitive function. 360 healthy individuals aged 60 years and older, living in East Anglia, UK will be recruited to the study, stratified into one of three risk groups (cohorts) for developing dementia based on their cognitive function. Participants will attend study appointments every six months over four years, providing stool and blood samples and a health questionnaire. Participants will also undergo physical measurements and cognitive tests at alternating appointments, and undergo Optical Coherence Tomography scans at 3 timepoints. Two subgroups of participants in the study will provide colonic tissue biopsies (n = ≥30 from each cohort), and brain imaging (n = 30) at two timepoints. Discussion This study will provide new insights into the gut-(microbiota)-brain axis and the relationship between age-associated changes in gut microbe populations and cognitive health. Such insights could help develop new microbe-based strategies to improve lifelong health and wellbeing. Trial registration This study is registered in the ClinicalTrials.gov Database with ID: NCT04199195 Registered: May 14, 2019.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0276118
DOI:
10.1371/journal.pone.0276118.g001
DOI:
10.1371/journal.pone.0276118.t001
DOI:
10.1371/journal.pone.0276118.t002
DOI:
10.1371/journal.pone.0276118.s001
DOI:
10.1371/journal.pone.0276118.s002
DOI:
10.1371/journal.pone.0276118.s003
DOI:
10.1371/journal.pone.0276118.r001
DOI:
10.1371/journal.pone.0276118.r002
DOI:
10.1371/journal.pone.0276118.r003
DOI:
10.1371/journal.pone.0276118.r004
DOI:
10.1371/journal.pone.0276118.r005
DOI:
10.1371/journal.pone.0276118.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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