In:
Clinical Nuclear Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. 8 ( 2021-8), p. 621-626
Abstract:
This article aims to explore the prognostic role of 18 F-FDG PET/CT metabolic parameters in stage I lung adenocarcinoma patients. Patients and Methods One hundred eighty pathological stage I lung adenocarcinoma patients were retrospectively reviewed. Semiquantitative analysis of FDG tumor uptake was performed with TrueD software on the Siemens Leonardo workstation. SUV mean and MTV were calculated using SUV threshold of 41% of SUV max ; the total lesion glycolysis (TLG) was calculated as the product of SUV mean and MTV. Correlation was evaluated using Spearman correlation coefficient. Maximally selected rank statistics was performed to detect the optimal cutoff used for dichotomizing each PET parameter (6.5 for SUV mean , 9.6 for SUV max , and 19.1 for TLG). Results Our main finding was the significant correlation between 18 F-FDG PET/CT parameters (SUV mean , SUV max , and TLG) and disease-free survival in pathologic stage I non–small cell lung cancer. SUV mean has the greatest accuracy in recurrence prediction (integrated area under the curve, 0.803; 95% confidence interval, 0.689–0.918). We run the maximally selected rank statistics to provide the classification of observations in 2 groups by a continuous predictor parameter; the free from recurrence rate was significantly greater in patients with SUV mean ≤6.5, SUV max ≤9.6, and TLG ≤19.1. Conclusions Our research supports the hypothesis that SUV mean , SUV max , and TLG are well correlated with free from recurrence rate in stage I adenocarcinoma patients, subjected to pulmonary lobectomy. Our findings also indicate these markers as promising prognostic indicators.
Type of Medium:
Online Resource
ISSN:
1536-0229
,
0363-9762
DOI:
10.1097/RLU.0000000000003714
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
2045053-9
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