In:
Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2016 ( 2016), p. 1-6
Abstract:
Renal transplantation (RT), has been considered the best therapeutic option for end stage renal disease (ESRD). Objective . To determine the effect of RT on the evolution of oxidative DNA status. Methods . Prospective cohort ( N = 50 receptors of RT); genotoxic damage, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and DNA repair enzyme, human 8-oxoguanine-DNA-N- glycosylase-1 (hOGG1); and antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GPx), were evaluated. Results . Before RT , 8-OHdG were significantly elevated ( 11.04 ± 0.90 versus 4.73 ± 0.34 ng/mL) compared to healthy controls ( p = 0.001 ), with normalization after 6 months of 4.78 ± 0.34 ng/mL ( p 〈 0.001 ). The same phenomenon was observed with hOGG1 enzyme before RT with 2.14 ± 0.36 ng/mL ( p = 0.01 ) and decreased significantly at the end of the study to 1.20 ng/mL ( p 〈 0.001 ) but was higher than controls, 0.51 ± 0.07 ng/mL ( p 〈 0.03 ). Antioxidant SOD was elevated at 24.09 ± 1.6 IU/mL versus healthy controls ( p = 0.001 ) before RT; however, 6 months after RT it decreased significantly to 16.9 ± 1.6 IU/mL ( p = 0.002 ), without achieving the levels of healthy controls ( p = 0.01 ). The GPx, before RT, was significantly diminished with 24.09 ± 1.6 IU/mL versus healthy controls (39.0 ± 1.58) ( p = 0.01 ), while, in the final results, levels increased significantly to 30.38 ± 3.16 IU/mL ( p = 0.001 ). Discussion . Patients with ESRD have important oxidative damage before RT. The RT significantly reduces oxidative damage and partially regulates the antioxidant enzymes (SOD and GPx).
Type of Medium:
Online Resource
ISSN:
1942-0900
,
1942-0994
DOI:
10.1155/2016/5757645
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2455981-7
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