In:
The Journal of Dermatology, Wiley, Vol. 45, No. 11 ( 2018-11), p. 1312-1318
Abstract:
Recently, herpes zoster ( HZ ) has been identified as a risk factor for stroke, but there have been few studies on the relationship between HZ and other cardiovascular diseases ( CVD ), including myocardial infarction ( MI ) and heart failure ( HF ). The purpose of this study was to investigate the risk of HZ occurrence after CVD and the occurrence of CVD after HZ . This was a retrospective case–control study based on the National Health Insurance System claims database for 20 311 patients with HZ and 13 980 patients with CVD and 1:5 age‐ and sex‐matched control subjects for each from January 2006 to December 2013. We evaluated the reciprocal relationship between HZ and CVD including MI , ischemic stroke and HF . Severe HZ requiring hospitalization independently increased the risk of subsequent MI (hazard ratio [ HR ], 1.831; 95% confidence interval [ CI ], 1.354–2.476)] , ischemic stroke ( HR , 1.523; 95% CI , 1.212–1.915) and HF ( HR , 2.034; 95% CI , 1.615–2.562) during the study period. Likewise, patients with an episode of MI , ischemic stroke or HF were also at increased risk of HZ hospitalization (after MI : HR , 1.625; 95% CI , 1.144–2.308; after stroke: HR , 1.518; 95% CI , 1.177–1.957; and after HF : HR , 1.485, 95% CI 1.041–2.117). Our results suggest that there is a significant reciprocal relationship between severe HZ requiring hospitalization and CVD including MI , ischemic stroke and HF .
Type of Medium:
Online Resource
ISSN:
0385-2407
,
1346-8138
DOI:
10.1111/jde.2018.45.issue-11
DOI:
10.1111/1346-8138.14597
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2222121-9
Bookmarklink
