In:
Russian Journal of Parasitology, Institute of Fundamental and Applied Parasitology of Animals and Plants, Vol. 16, No. 4 ( 2023-01-02), p. 432-438
Abstract:
The purpose of the research is to study Praziquantel and Moxidectin pharmacokinetics in dogs after Helmimax administration. Materials and methods . Helmimax pharmacokinetics was studied on 8 adult male dogs of different breeds aged 2 to 5 years and weighing 15–35 kg. Helmimax was administered orally in the fasted state with a small amount of feed at a dose of 5 mg/kg for Praziquantel and 0.25 mg/kg for Moxidectin at the rate of 1 tablet per 10 kg of body weight. Blood was sampled at various periods after the administration. The collected blood underwent sample processing: formed element and protein precipitation, solid-phase extraction, and microfiltration. The active components were analyzed and detected by the HPLC-MS/MS. Active substances in the blood plasma were determined according to the developed technique which had been validated. The device was calibrated before the measurement. Results and discussion . As a result of the studies, the Praziquantel and Moxidectin pharmacokinetic parameters were calculated. The maximum concentration was 0.240 and 0.130 μg/mL, the time-to-peak concentration was 2.15 and 1.48 hours, and the elimination half-life was 8.41 and 3.61 hours for Moxidectin and Praziquantel, respectively.
Type of Medium:
Online Resource
ISSN:
2541-7843
,
1998-8435
DOI:
10.31016/1998-8435-2022-16-4
DOI:
10.31016/1998-8435-2022-16-4-432-438
Language:
Unknown
Publisher:
Institute of Fundamental and Applied Parasitology of Animals and Plants
Publication Date:
2023
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