In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 30, No. 3 ( 2015-03), p. 582-590
Abstract:
The prognostic role of noninvasive assessments of liver fibrosis has been evolving. Our aim was to investigate the prognostic value of liver stiffness measurement ( LSM ) with transient elastography and serum‐based H ui index to predict hepatic events and deaths in chronic hepatitis B ( CHB ) patients. Methods The main prospective cohort included 1555 consecutive CHB patients referred for transient elastography examination; a subgroup of 980 patients underwent follow‐up assessments at least 3 years later formed the serial cohort. Cox proportional hazard model was performed to determine the relationship of LSM , H ui index and other clinical variables with hepatic events and deaths. Results During a mean follow‐up of 69 ± 9 months, 119 patients (7.6%) developed hepatic events or deaths. Hepatic event‐free survival was significantly decreased with increasing stages of LSM and H ui index. The 5‐year cumulative probability of hepatic event‐free survival of patients of S tage 1–7 of LSM were 99.3%, 98.8%, 95.7%, 90.9%, 89.6%, 74.6%, and 50.0%, respectively; that of S tage 1 to 3 of H ui index were 98.2%, 93.1%, and 77.5%, respectively. Independent predictors of hepatic event‐free survival were age, baseline LSM , and follow‐up H ui index. Serum ALT and body mass index affected the accuracy of prediction by LSM . Patients remained early stages of LSM or H ui index at follow‐up visit had better survival compared to those remained at late stages. Conclusion Baseline and change in noninvasive parameters of liver fibrosis, LSM and H ui index, are accurate to predict hepatic event‐free survival in CHB patients.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2015.30.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2006782-3
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