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1

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A life-threatening bleeding prediction model for immune thrombocytopenia based on personalized machine learning: a nationwide prospective cohort study

An, Zhuo-Yu ; Wu, Ye-Jun ; Hou, Yu ; [et al.]

Elsevier BV ; 2023

In: Science Bulletin Vol. 68, No. 18 ( 2023-09), p. 2106-2114

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In: Science Bulletin, Elsevier BV, Vol. 68, No. 18 ( 2023-09), p. 2106-2114

Type of Medium: Online Resource

ISSN: 2095-9273

URL: Article

DOI: 10.1016/j.scib.2023.08.001

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2069521-4

detail.hit.zdb_id: 2816140-3

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2

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Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma

Chen, Wen-Hui ; Tang, Lin-Quan ; Wang, Feng-Wei ; [et al.]

Springer Science and Business Media LLC ; 2014

In: BMC Cancer Vol. 14, No. 1 ( 2014-12)

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In: BMC Cancer, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2014-12)

Type of Medium: Online Resource

ISSN: 1471-2407

URL: Article

DOI: 10.1186/1471-2407-14-583

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2041352-X

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3

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Luteolin Inhibits Breast Cancer Development and Progression In Vitro and In Vivo by Suppressing Notch Signaling and Regulating MiRNAs

Sun, Da-Wei ; Zhang, He-Da ; Mao, Ling ; [et al.]

S. Karger AG ; 2015

In: Cellular Physiology and Biochemistry Vol. 37, No. 5 ( 2015), p. 1693-1711

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In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 37, No. 5 ( 2015), p. 1693-1711

Abstract: Background/Aims: This study aims to investigate the effect of Luteolin on breast cancer in vitro and in vivo and the interaction between miRNAs and Notch signaling after Luteolin intervention, and illustrates the possible underlying mechanism and regulation loop. Methods: Cell growth/survival assays and cell cycle analyses were performed to evaluate cell survival in vitro. Scratch tests, cell invasion assays and tube formation assays were carried out to analyze cell viability and identify the impact of Luteolin on angiogenesis. Critical components in the Notch pathway including proteins and mRNAs were detected by Western blotting analyses, ELISA assays and real-time reverse transcription-polymerase chain reaction. Matrix metalloproteinases activity was evaluated by gelatin zymography analyses. MiRNAs were analyzed by miRNA expression assays. After MDA-MB-231 cells were separately transfected with Notch-1 siRNA/cDNA and miRNA mimics, the above assays were also carried out to examine potential tumor cell changes. Xenograft models were applied to evaluate the treatment potency of Luteolin in breast cancer. Results: Luteolin significantly inhibited breast cancer cell survival, cell cycle, tube formation and the expression of Notch signaling-related proteins and mRNAs, and regulated miRNAs. After introducing Notch-1 siRNA and miRNA mimics, MDA-MB-231 cells presented with changes in miRNA levels, reduced Notch signaling-related proteins, and decreased tumor survival, invasion and angiogenesis. Conclusion: Luteolin inhibits Notch signaling by regulating miRNAs. However, the effect of miRNAs on the Notch pathway could be either Luteolin-dependent or Luteolin-independent. Furthermore, Notch-1 alteration may inversely change miRNAs levels. Our data demonstrates that Luteolin, miRNAs and the Notch pathway are critical in breast cancer development and prognosis.

Type of Medium: Online Resource

ISSN: 1015-8987 , 1421-9778

URL: Article

DOI: 10.1159/000438535

Language: English

Publisher: S. Karger AG

Publication Date: 2015

detail.hit.zdb_id: 1482056-0

SSG: 12

SSG: 15,3

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4

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Annexin A3 as a Potential Target for Immunotherapy of Liver Cancer Stem-Like Cells

Pan, Qiu-Zhong ; Pan, Ke ; Wang, Qi-Jing ; [et al.]

Oxford University Press (OUP) ; 2015

In: Stem Cells Vol. 33, No. 2 ( 2015-02-01), p. 354-366

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In: Stem Cells, Oxford University Press (OUP), Vol. 33, No. 2 ( 2015-02-01), p. 354-366

Abstract: Cancer stem-like cells/cancer-initiating cells (CSCs/CICs) are considered to represent a small population of cancer cells that is resistant to conventional cancer treatments and responsible for tumor recurrence and metastasis. The aim of this study was to establish CSC/CIC-targeting immunotherapy. In this study, we found that Annexin A3 (ANXA3) was preferentially expressed in CSCs/CICs derived from hepatocellular carcinoma (HCC) cells compared to non-CSCs/CICs. In HCC samples, high levels of ANXA3 correlated with expansion of CD133+ tumor cells representing CSCs/CICs in HCC; the combination of high levels of ANXA3 and CD133 was associated with progression of HCC. Overexpression of ANXA3 increased the proportion of CD133+ cells, enhancing their tumorigenicity. On the contrary, knockdown of ANXA3 decreased CD133+ cells and inhibited tumorigenicity. The mechanistic study revealed that ANXA3-mediated maintenance of HCC CSCs/CICs activity was likely involved with the HIF1A/Notch pathway. Using ANXA3 as a target, ANXA3-transfected dendritic cells could induce more functionally active T cells and these effector T cells could superiorly kill CD133+ HCC CSCs/CICs in vitro and in vivo. Taken together, our findings suggest that ANXA3 plays a role in HCC CSC/CIC maintenance, and that ANXA3 may represent a potential CSC/CIC-specific therapeutic target for improving the treatment of HCC. Stem Cells 2015;33:354–366

Type of Medium: Online Resource

ISSN: 1066-5099 , 1549-4918

URL: Article

DOI: 10.1002/stem.1850

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2015

detail.hit.zdb_id: 2030643-X

detail.hit.zdb_id: 1143556-2

detail.hit.zdb_id: 605570-9

SSG: 12

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5

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Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma

Zhang, Xiao‐Fei ; Pan, Qiu‐Zhong ; Pan, Ke ; [et al.]

Wiley ; 2016

In: Molecular Carcinogenesis Vol. 55, No. 1 ( 2016-01), p. 64-76

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In: Molecular Carcinogenesis, Wiley, Vol. 55, No. 1 ( 2016-01), p. 64-76

Abstract: Ubiquitination factor E4B (UBE4B) has been speculated to have contradictory functions upon tumorigenesis as an oncogene or tumor suppressor in different types of cancers. We investigated the expression and prognostic role of UBE4B in primary hepatocellular carcinoma (HCC) using cell lines and 149 archived HCC samples. Correlation between the functions of UBE4B in HCC was also explored. We used human HCC cell lines (HepG2, Hep3B, SK‐Hep1, Huh7, SMMC‐7721, BEL‐7402) and a normal hepatocyte cell line (LO2) along with HCC samples from patients who had undergone resection for HCC previously at our hospital. A battery of methods (real‐time quantitative polymerase chain reaction; Western blotting; immunohistochjemical analyses; cell proliferation and colony formation assays; cell migration and cell invasion assays) were employed to assess various aspects of UBE4B.We found that UBE4B expression was upregulated aberrantly at mRNA and protein levels in human primary HCC tissues. Amplified expression of UBE4B was highly correlated with poor outcome. Silencing of UBE4B expression by siRNA inhibited the proliferation, colony formation, migration and invasion of HCC cells in vitro, and resulted in significant apoptosis that was associated with downregulation of expression of Bcl‐2 and upregulation of expression of total p53, p‐p53, Bax and Cleaved‐Caspase3 in HCC cells. Our findings suggested that UBE4B might have an oncogenic role in human primary HCC, and that it could be used as a prognostic marker (as well as a potential molecular target) for the treatment of HCC. © 2015 Wiley Periodicals, Inc.

Type of Medium: Online Resource

ISSN: 0899-1987 , 1098-2744

URL: Issue

URL: Article

DOI: 10.1002/mc.v55.1

DOI: 10.1002/mc.22259

Language: English

Publisher: Wiley

Publication Date: 2016

detail.hit.zdb_id: 2001984-1

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6

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Study on Dynamic Performance of Cutter Head and Cutter System of Rock Tunneling Set-up

Hong, Kai Rong ; Zhao, Hai Jun ; Chang, Jia Dong ; [et al.]

Trans Tech Publications, Ltd. ; 2011

In: Applied Mechanics and Materials Vol. 143-144 ( 2011-12), p. 512-516

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In: Applied Mechanics and Materials, Trans Tech Publications, Ltd., Vol. 143-144 ( 2011-12), p. 512-516

Abstract: Several modals on Tunnel Boring Machine (TBM) in tunneling are introduced, the revolving rock tunneling simulator set-up is designed, the finite element model of cutter parts of the experimental bench is built, and free mode analysis of it is performed, and the model on system of cutter head, cutter and rock is established. It is shown that natural frequency on the cutter parts is higher, the frequency of first step is 4536Hz, and the most modes are deformations of the cutter loop, vibration acceleration of the cutter decreases with fracture tunnel width increasing, in some degree broken rock mechanics is achieved, foundation is provided for improving using life and adaptability of the cutter, and optimizing arrangement of plate cutter on the cutter head, and finally realizing high efficiency and low energy consumption.

Type of Medium: Online Resource

ISSN: 1662-7482

URL: Issue

URL: Article

DOI: 10.4028/www.scientific.net/AMM.143-144

DOI: 10.4028/www.scientific.net/AMM.143-144.512

Language: Unknown

Publisher: Trans Tech Publications, Ltd.

Publication Date: 2011

detail.hit.zdb_id: 2251882-4

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7

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Producing Mechanism on Flow Regeneration Noise from Muffler Element with Inserted Tube

Zhao, Hai Jun ; Chang, Jia Dong ; Wang, Hai Xia ; [et al.]

Trans Tech Publications, Ltd. ; 2012

In: Advanced Materials Research Vol. 538-541 ( 2012-6), p. 1977-1980

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In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 538-541 ( 2012-6), p. 1977-1980

Abstract: Structure parameters of muffler element with inserted tube are firstly determined, it is analyzed to the inserted length effecting on sound power of flow regeneration noise and frequency characteristic, and distribution feature of flow velocity and turbulence kinetic energy is explored by numerical computation of flow field. It is shown that flow regeneration noise of muffler element with inserted tube forms according to confined incomplete flow-inject, it presents wide frequency band, and its energy focus on middle and low frequency, especially it is about 600Hz, Strouhal Number is 0.5. When its structure parameters is constant, distribution feature of flow velocity and turbulence kinetic energy doesn’t change with flow velocity, and difference is numerical dimension, and turbulence kinetic energy distributes near inserted tube in wall, this is area occurring flow regeneration noise, so producing mechanism of flow regeneration noise from muffler element with inserted tube is achieved.

Type of Medium: Online Resource

ISSN: 1662-8985

URL: Issue

URL: Article

DOI: 10.4028/www.scientific.net/AMR.538-541

DOI: 10.4028/www.scientific.net/AMR.538-541.1977

Language: Unknown

Publisher: Trans Tech Publications, Ltd.

Publication Date: 2012

detail.hit.zdb_id: 2265002-7

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Construction and Installation Technology Evaluation System of Residential Foundation Research Based on AHP

Zhang, Hai Xia ; Zhang, De Bing ; Li, Guo Chang ; [et al.]

Trans Tech Publications, Ltd. ; 2014

In: Applied Mechanics and Materials Vol. 638-640 ( 2014-9), p. 1582-1585

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In: Applied Mechanics and Materials, Trans Tech Publications, Ltd., Vol. 638-640 ( 2014-9), p. 1582-1585

Abstract: With the development and application of steel structure residence, the corresponding evaluation system is developing and also remains to be perfect. This paper, integrated theory and similarity evaluation system for information, compared with the current commonly used methods, using the improved AHP, according to the current national standards, the evaluation system on the foundation construction installation technology is established.

Type of Medium: Online Resource

ISSN: 1662-7482

URL: Issue

URL: Article

DOI: 10.4028/www.scientific.net/AMM.638-640

DOI: 10.4028/www.scientific.net/AMM.638-640.1582

Language: Unknown

Publisher: Trans Tech Publications, Ltd.

Publication Date: 2014

detail.hit.zdb_id: 2251882-4

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Hydrothermal growth of scandium-doped ZnO crystals

Zuo, Yan-Bin ; Lu, Fu-Hua ; Zhang, Chang-Long ; [et al.]

Elsevier BV ; 2011

In: Journal of Crystal Growth Vol. 318, No. 1 ( 2011-03), p. 513-515

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In: Journal of Crystal Growth, Elsevier BV, Vol. 318, No. 1 ( 2011-03), p. 513-515

Type of Medium: Online Resource

ISSN: 0022-0248

URL: Article

DOI: 10.1016/j.jcrysgro.2010.11.088

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 1466514-1

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Effect Factors Analysis of Flow Generation Noise from Muffler Element with Inserted Tube

Zhao, Hai Jun ; Wang, Hai Xia ; Chang, Jia Dong ; [et al.]

Trans Tech Publications, Ltd. ; 2012

In: Advanced Materials Research Vol. 605-607 ( 2012-12), p. 1149-1153

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In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 605-607 ( 2012-12), p. 1149-1153

Abstract: Using orthogonal experimental design method structure parameters of work piece for muffler element with inserted tube are determined. Flow noise regeneration of them is measured on the self development test bench. Relationship model on total sound power of flow regeneration noise and structure parameter and flow velocity is established utilizing Multiple linear regression method, model parameters are solved making use of hyper static least square method. Significance test of the model is performed, the law of total sound power level for muffler element flow regeneration noise changing with the parameters is discussed. Result shows that the established models is all highly significant under 0.01 levels, and inserted length of outlet tube and inn-diameter of inlet tube have higher effect on the flow generation noise, and decreasing the inserted length and the inn-diameter are in favor of reducing flow generation noise. But inserted length of inlet tube and expansion ratio have little effect on the flow generation noise.

Type of Medium: Online Resource

ISSN: 1662-8985

URL: Issue

URL: Article

DOI: 10.4028/www.scientific.net/AMR.605-607

DOI: 10.4028/www.scientific.net/AMR.605-607.1149

Language: Unknown

Publisher: Trans Tech Publications, Ltd.

Publication Date: 2012

detail.hit.zdb_id: 2265002-7

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Kooperativer Bibliotheksverbund

Berlin Brandenburg