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  • 1
    Online Resource
    Online Resource
    Application of degradation technology of light-emitting diode and auto-monitoring system for harmful substances in farrowing areas of a specific pathogen-free pig farm
    Orion Scholar Journals Publication ; 2023
    In:  International Journal of Scientific Research Updates Vol. 6, No. 1 ( 2023-8-30), p. 059-066
    Details
    In: International Journal of Scientific Research Updates, Orion Scholar Journals Publication, Vol. 6, No. 1 ( 2023-8-30), p. 059-066
    Abstract: In pig farms, disinfectants are applied for the effective cleaning and disinfection regimen. Moreover, the ideal detergents should be left no residue after use which might harbour micro-organisms. Additionally, it should be non-toxic to pigs and must have minimal environmental impacts. Therefore, in order to avoid detergent residues and possible effects on pigs, staffs, and environment, the development of a novel technology without chemicals to kill micro-organisms, degrade atmospheric fine particulate matter and harmful gases in the pig farms is pioneering and future potential. In this study, application of degradation technology of light-emitting diode (LED) and auto-monitoring system for harmful substances in farrowing area of a specific pathogen-free pig farms. The LED light exhibit an antibacterial efficacy of up to 89.1%. They are capable of reducing ammonia concentrations within the environment by 45%, hydrogen sulfide levels by 68.8%, and curbing PM2.5 concentrations by 80%. Collectively, these findings underscore the considerable potential of this degradation technology via visual light in effectively eliminating detrimental substances.
    Type of Medium: Online Resource
    ISSN: 2783-0160
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.53430/ijsru.2023.6.1
    DOI: 10.53430/ijsru
    DOI: 10.53430/ijsru.2023.6.1.0060
    Language: Unknown
    Publisher: Orion Scholar Journals Publication
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    Papaya polysaccharides regulate intestinal flora in vivo
    Open Access Research Journals Publication ; 2023
    In:  Open Access Research Journal of Life Sciences Vol. 6, No. 1 ( 2023-7-30), p. 017-026
    Details
    In: Open Access Research Journal of Life Sciences, Open Access Research Journals Publication, Vol. 6, No. 1 ( 2023-7-30), p. 017-026
    Abstract: Mainly, papaya is a fruit grown in tropical and subtropical regions. It is a nutritionally rich fruit that is widely recognized for its various benefits. There are some common benefits of papaya include improvement of digestion, abundant vitamin C, immune system boosts, promotion of cardiovascular health, support of eye health, enhance of gut health etc. Papaya polysaccharides (PP) are natural polysaccharide compounds extracted from papaya. They are complex compounds composed of polysaccharide molecules obtained from papaya pulp, peel, or juice. PP are believed to possess various pharmacological activities and health benefits include immunomodulation, antioxidant effects, anti-inflammatory effects, blood glucose-lowering effects, hepatoprotective effects etc. It is important to note that although papaya polysaccharides have potential health benefits, current research on them is still relatively limited. Further scientific studies are needed to validate and deepen our understanding of their mechanisms of action and their application in different disease conditions. Therefore, we focused on the effects of PP regulate intestinal flora in vivo in this study. The results were revealed that long-read sequencing platform, Oxford Nanopore Technologies (ONT), was used to classify the gut microbiota in rat fecal samples. A total of 945 bacterial strains were identified through comprehensive strain identification. The obtained sequencing reads were analyzed using the CLC Genomics Workbench software. Moreover, CLC Genomics Workbench software performed Weighted UniFrac and Bray-Curtis analyses to measure the dissimilarity of identified bacterial species between different groups. Subsequently, the PERMANOVA statistical method was employed to determine the significance of differences in the composition of bacterial species between groups. Comparing the relative abundance changes of identified bacterial species in the fecal samples after 28 days of low-dose PP consumption [100 mg/kg body weight (BW)] with the normal diet group, 46 intestinal bacterial strains showed statistically significant differences. After comparing the relative abundance changes of identified bacterial species in the fecal samples following 28 days of high-dose PP consumption (200 mg/kg BW) with the normal diet group, 45 intestinal bacterial strains showed statistically significant differences. Using CLC Genomics Workbench software, a heat map was generated by selecting bacter ial strains in the high (28) group that exhibited a relative abundance increase or decrease of more than 4-fold. After database analysis, a total of 945 intestinal bacterial strains were identified in this study. It was observed that the proportions of intestinal bacterial communities changed after consuming PP. Among them, 42 bacterial strains showed an increase in abundance after PP consumption. According to the criteria for determining good and bad bacteria, out of the total 118 bacterial genera considered, 69 belong to the "good bacteria" category (probable probiotics), while 49 belong to the "bad bacteria" category (potential pathogens). After PP treatment, PP (100 mg/kg BW and 200 mg/kg BW) can decrease the percentage of potential pathogens in the stool of SD rats. Taken all results together, to consume PP for 28 days can alter the composition of SD rats’ gut microbiota. Further analysis is needed to explore the effects of changes in SD rats’ gut microbiota on relevant mechanisms in the body. The findings of this study can serve as a foundation for the application of PP in regulating gut microbiota as raw materials or products.
    Type of Medium: Online Resource
    ISSN: 2783-025X
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.53022/oarjls.2023.6.1
    DOI: 10.53022/oarjls
    DOI: 10.53022/oarjls.2023.6.1.0047
    Language: Unknown
    Publisher: Open Access Research Journals Publication
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Dragon fruit (Hylocereus undatus (Haw.) Britt.) powders attenuate ulcerative disease symptoms via dextran sulfate sodium-induced mouse model
    SRR Publications ; 2023
    In:  International Journal of Scholarly Research in Life Sciences Vol. 2, No. 1 ( 2023-9-30), p. 001-013
    Details
    In: International Journal of Scholarly Research in Life Sciences, SRR Publications, Vol. 2, No. 1 ( 2023-9-30), p. 001-013
    Abstract: Dragon fruit is cactus based fruit that has loads of health benefits such as lowering risks of a blood sugar spike, aids in digestion etc. Its nutritional content is rich in vitamin C, vitamin E, magnesium, iron etc. Its functions on the physiological regulation are well known. Inflammatory bowel diseases (IBD) are multifactorial chronic intestinal disorders. Currently, mesalamine etc. and therapeutic strategies were suggested for IBD therapy. However, the etiology of IBD remains unclear which is an ongoing challenge and side effects of therapeutic drugs must be also considered. Thus, the aim of this study was evaluated the efficacy and therapeutic strategies investigations on the attenuated IBD symptoms via administrating three doses of dragon fruit powders in the 2% dextran sulfate sodium (DSS)-induced IBD mouse model. The female C57BL/6 mice were divided respectively the normal control group (n = 10), the negative control group (n = 10), three dose groups (n = 10 per group) of dragon fruit powders (250 mg/kg BW, 500 mg/kg BW, and 1,000 mg/kg BW). Exception of the normal control group, other groups were administrated with 2% DSS for 5 days. Later, the normal drinking water was provide to C57BL/6 mice until the end of the experiment. At the end of the experiment, the body weight (BW), the stool appearance/status, the macroscopic and microscopic colonic injuries, and myeloperoxidase (MPO) activity were monitored, measured and scored. The results were showed that BW of C57BL/6 mice in the negative control group, three dragon fruit powder groups was gradually reduced during the IBD period induced by 2% DSS, and BW of C57BL/6 mice gradually increased when the 2% DSS in drinking water was replaced with the normal drinking water. When the experiment was carried out to the 3rd to 4th week, BW of the negative control group was significantly lower than that of the normal control group. The stool appearance/status was presented that stool score in the negative control group was significantly higher than that in the normal control group (p 〈 0.001). The stool score in the high-dose dragon fruit powder group was significantly lower than that in the negative control group (p 〈 0.001). The macroscopic colons of C57BL/6 mice were performed at the end of the experiment. (1) Gut weight: It can be seen that gut weight in the normal control group is lowest and the gut weight in the negative control group is highest between all groups. The gut weight in the negative control group was higher than that in the normal control group, medium-dose dragon fruit powder group, and high-dose dragon fruit powder group were seen. (2) Gut length: It can be seen that gut length in the normal control group is longest. The gut length in the normal control group is significantly longer than that in the other groups. Exception of the normal control group, other groups were not significant difference compared to each other. (3) Gut weight-to-gut length ratio: It can be seen that gut weight-to-gut length ratio in the normal control group is lowest and the gut weight-to-gut length ratio in the negative control group is highest between all groups. The gut weight-to-gut length ratio in the negative control group was significantly higher than that in the normal control group (p 〈 0.01). The gut weight-to-gut length ratio in the high-dose dragon fruit powder group was significantly lower than that in the negative control group. The microscopic colons of C57BL/6 mice was performed at the end of the experiment. The pathological analysis items were divided into ulcer area ratio, mucosal ulcer depth, inflammatory cell infiltration, and submucosal edema. Total histopathologic scores in the 2% DSS-induced group was also significantly higher than that of the normal control group. Finally, the evaluating MPO activity was performed by using MPO activity assay kit. It can be seen that MPO activity was significant higher in the negative control group than that in the normal control group. MPO activity in the three dragon fruit powder groups were significant lower than that in the negative control group. Taken all results together, the consumption of medium-dose (500 mg/kg BW) and high-dose (1,000 mg/kg BW) dragon fruit powders has a positive improvement effect on relieving various symptoms caused by IBD via a successful 2% DSS-induced IBD mouse model.
    Type of Medium: Online Resource
    ISSN: 2961-3264
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.56781/ijsrls.2023.2.1
    DOI: 10.56781/ijsrls
    DOI: 10.56781/ijsrls.2023.2.1.0030
    Language: Unknown
    Publisher: SRR Publications
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    The Medication Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label
    Wiley ; 2019
    In:  Clinical Pharmacology & Therapeutics Vol. 105, No. 1 ( 2019-01), p. 112-120
    Details
    In: Clinical Pharmacology & Therapeutics, Wiley, Vol. 105, No. 1 ( 2019-01), p. 112-120
    Abstract: Specific ethnic genetic backgrounds are associated with the risk of Stevens–Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple‐country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998–2017. A total 1,028 SJS/TEN cases were identified with the algorithm of drug causality for epidermal necrolysis. Furthermore, those medications labeled by the US Food and Drug Administration (FDA) as carrying a risk of SJS/TEN were also compared with the common causes of SJS/TEN in Asian countries. Oxcarbazepine, sulfasalazine, COX‐II inhibitors, and strontium ranelate were identified as new potential causes. In addition to sulfa drugs and beta‐lactam antibiotics, quinolones were also a common cause. Only one acetaminophen‐induced SJS was identified, while several medications (e.g., oseltamivir, terbinafine, isotretinoin, and sorafenib) labeled as carrying a risk of SJS/TEN by the FDA were not found to have caused any of the cases in the Asian countries investigated in this study.
    Type of Medium: Online Resource
    ISSN: 0009-9236 , 1532-6535
    URL: Issue
    URL: Article
    DOI: 10.1002/cpt.2019.105.issue-1
    DOI: 10.1002/cpt.1071
    RVK:
    XA 36900
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2040184-X
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Phase 1b/ 2 study of a radio-enhancer, PEP503 (NBTXR3), in combination with concurrent chemo-radiation in locally advanced or unresectable rectal cancer.
    American Society of Clinical Oncology (ASCO) ; 2022
    In:  Journal of Clinical Oncology Vol. 40, No. 16_suppl ( 2022-06-01), p. 3603-3603
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, No. 16_suppl ( 2022-06-01), p. 3603-3603
    Abstract: 3603 Background: PEP503 (aka NBTXR3) is a novel radio-enhancer composed of functionalized hafnium oxide nanoparticles that increases the energy deposition of radiotherapy. A phase 3 study in soft tissue sarcoma patients has significantly increased pCR and R0 when PEP503 was added to preop radiotherapy. This phase 1b/2 study was conducted with the aim to identify a recommended phase 2 dose (RP2D), and evaluate the efficacy of PEP503 intratumoral injection in combination with concurrent chemoradiation (CCRT) in patients with locally advanced rectal cancer (LARC). Methods: Patients with stage T3-T4 LARC (or with unresectable disease) suitable for neoadjuvant CCRT were enrolled. An intratumoral single administration of PEP503 (multiple punctures) was done 24 to 72 hours prior to IMRT of 50 Gy in 25 fractions of 2 Gy per fraction over 5-6 weeks with concurrent capecitabine or 5-FU. Traditional 3 + 3 design with 4 levels, 5%, 10%, 15%, and 22%, of the baseline GTV as measured by MRI, of PEP503 were assessed in Phase Ib. PEP503 nanoparticles intratumoral dispersion was analyzed by CT-scan. Surgery was performed 8 to 12 weeks after the completion of CCRT for patients with resectable tumors. Body kinetics was evaluated in Phase Ib. (ClinicalTrials.gov, NCT02465593) Results: Thirty-two (32) patients (male/female: 20/12; median age 62 years, range 38 to 76) were enrolled (1 dropped out before starting CCRT). In Phase 1b, 20 patients were treated and dose was escalated to 22%. RP2D was then determined as 22% with 6 patients treated at this dose level without DLT. Twelve (12) patients were included in the Phase 2. One (1) (3.2%) and 19 (61.3%) of evaluable patients (n = 31) had CR and PR, respectively, as the best tumor response across dose levels. No patient progressed as all evaluable patients (n = 31) achieved disease control for a DCR of 100%. Furthermore, twenty-five patients underwent surgery, of which 24 (96%) had microscopically clear resection margins and 5 of them (20%) had pathological complete response (pCR). The G3 AEs were diarrhea, ileus, thrombocytopenia, urosepsis, procedural haemorrhage, wound complication, hypokalaemia, and myalgia (all in 3.1%). No G4 AE were observed. The results of CT scans for nanoparticles dispersion demonstrated PEP503 remained within the tumor without leakage to the surrounding healthy tissues, before and after CCRT. In most patients, hafnium was not detected or below the Lower Limit of Quantification (LLOQ) in the circulation 60 minutes after PEP503 injection and was not found in urine. Conclusions: A single intratumoral injection of PEP503 in locally advanced or unresectable rectal adenocarcinoma undergoing capecitabine or 5-FU based CCRT is feasible and safe. The preliminary observed efficacy results may warrant further examination in larger clinical studies. Clinical trial information: NCT02465593.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2022.40.16_suppl.3603
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2022
    detail.hit.zdb_id: 2005181-5
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  • 6
    Online Resource
    Online Resource
    Rabeprazole Can Overcome the Impact of CYP2C19 Polymorphism on Quadruple Therapy : Rabeprazole and CYP2C19 Polymorphism on Quadruple Therapy
    Wiley ; 2010
    In:  Helicobacter Vol. 15, No. 4 ( 2010-07-16), p. 265-272
    Details
    In: Helicobacter, Wiley, Vol. 15, No. 4 ( 2010-07-16), p. 265-272
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.2010.15.issue-4
    DOI: 10.1111/j.1523-5378.2010.00761.x
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2020336-6
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Personalized neoantigen-based T cell therapy triggers cytotoxic lymphocytes expressing polyclonal TCR against metastatic ovarian cancer
    Elsevier BV ; 2023
    In:  Biomedicine & Pharmacotherapy Vol. 169 ( 2023-12), p. 115928-
    Details
    In: Biomedicine & Pharmacotherapy, Elsevier BV, Vol. 169 ( 2023-12), p. 115928-
    Type of Medium: Online Resource
    ISSN: 0753-3322
    URL: Article
    DOI: 10.1016/j.biopha.2023.115928
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1501510-5
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  • 8
    Online Resource
    Online Resource
    Establishment of an in vitro flow cytometric detection method for lipid-accumulated cells
    Scientific Research Archives ; 2022
    In:  International Journal of Science and Technology Research Archive Vol. 2, No. 1 ( 2022-02-28), p. 061-067
    Details
    In: International Journal of Science and Technology Research Archive, Scientific Research Archives, Vol. 2, No. 1 ( 2022-02-28), p. 061-067
    Abstract: Eukaryotic cells can store and converse excess lipid to the cytosolic lipid droplets. Adipogenesis of preadipocytes has been often used to study the molecular basis and the effect of obesity drugs on fat cell conversion. Many methods were developed for the detection of the cytosolic lipid droplets as Nile red, BODIPY 493/503 (4, 4-difluoro-1, 3, 5, 7, 8-pentamethyl-4-bora-3a, 4adiaza-s-indacene), BODIPY 665/676, 1,6-diphenylhexatriene (DPH), DAPI, Hoechst, Sudan III, and Oil-red O. The differences in the spectral properties of these lipophilic dyes and their advantages of each are discussed. In this study, an in vitro flow cytometric detection method was established for the detection of lipid-accumulated cells. Commonly, the longer the period of adipogenic induction, the greater the quantity of lipid in fat cell can accumulate. Thus, to determine whether increasing the fat stored within a cell would result in the greater granularity. 3T3-L1 cells in culture were hormonally induced for adipogenesis. Then, these cells were dissociated and analyzed in a flow cytometer at 0, 5, and 10 days post-induction. After adipogenic induction, the cells had become increasingly heterogeneous in their cellular granularity. The cells containing greater granular structure were markedly increased, and this increase in granularity positively correlated with the time of the post-adipogenic induction. On the other analysis, the 0 and 10 days post adipogenic induction of 3T3-L1 cells were gated for 4 regions. The R1 region contains cells with a level of granularity similar to that seen in the control cells (non-adipogenic induction), whereas R2 to R4 regions contain cells with increasing granularity. According to all data, we have successfully established an in vitro flow cytometric detection method for the detection of lipid-accumulated cells. We wish this method will be applied on the research of obesity drugs and the design of therapeutic strategies for obesity in the future.
    Type of Medium: Online Resource
    ISSN: 0799-6632
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.53771/ijstra.2022.2.1
    DOI: 10.53771/ijstra
    DOI: 10.53771/ijstra.2022.2.1.0026
    Language: Unknown
    Publisher: Scientific Research Archives
    Publication Date: 2022
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  • 9
    Online Resource
    Online Resource
    Malnutrition in acute heart failure with preserved ejection fraction: clinical correlates and prognostic implications
    Wiley ; 2019
    In:  ESC Heart Failure Vol. 6, No. 5 ( 2019-10), p. 953-964
    Details
    In: ESC Heart Failure, Wiley, Vol. 6, No. 5 ( 2019-10), p. 953-964
    Abstract: This study aimed to evaluate the prognostic significance of nutritional status in post‐discharge Asians with heart failure with preserved ejection fraction (HFpEF). Methods and results We examined the prognostic implications of body mass index (BMI) and nutritional markers among consecutive patients hospitalized for HFpEF. Nutritional metrics were estimated by serum albumin (SA), prognostic nutritional index (PNI), Controlling Nutritional Status (CONUT) score, and geriatric nutritional risk index. Among 1120 patients (mean age: 77.2 ± 12.6 years, 39.4% men), mean SA levels, PNI, CONUT scores, and geriatric nutritional risk index were 3.3 ± 0.6 g/dL, 40.2 ± 8.7, 5.5 ± 2.1, and 95.9 ± 14.5, respectively. Lean body size, higher white blood cell counts and C‐reactive protein levels, anaemia, and lack of angiotensin blocker use were independently associated with malnutrition (defined by SA 〈 3.5 g/dL). Higher SA levels [hazard ratio (HR): 0.67 (95% confidence interval, CI: 0.53–0.85)], higher PNI [HR: 0.97 (95% CI: 0.95–0.99)] , and higher geriatric nutritional risk index [HR: 0.98 (95% CI: 0.97–0.99)] (all P 〈 0.05) were all associated with longer survival, with higher CONUT score [HR: 1.08 (95% CI: 1.02–1.13)] exhibited higher mortality in Cox regression models and with higher SA levels/PNI but not BMI further contributing to the reduced rate of re‐hospitalization (both P 〈 0.05). Categorizing BMI (25 kg/m 2 as cut‐off) and nutritional status showed significantly higher mortality rates among patients with lower BMI/malnutrition than among those with BMI/better nutrition (SA level, PNI, and CONUT score, all P 〈 0.01). Restricted cubic spline regression revealed a marked survival benefit of better nutrition with increasing BMI (adjusted P interaction for both SA level and PNI: 〈 0.001; adjusted P interaction for CONUT score: 0.046). Conclusions Malnutrition was frequently and strongly associated with systemic inflammation in Asian patients hospitalized for acute HFpEF. Our findings also indicate that nutrition may play a pivotal role in metabolic protection in this population.
    Type of Medium: Online Resource
    ISSN: 2055-5822 , 2055-5822
    URL: Issue
    URL: Article
    DOI: 10.1002/ehf2.v6.5
    DOI: 10.1002/ehf2.12501
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2814355-3
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  • 10
    Online Resource
    Online Resource
    Associations of obesity and malnutrition with cardiac remodeling and cardiovascular outcomes in Asian adults: A cohort study
    Public Library of Science (PLoS) ; 2021
    In:  PLOS Medicine Vol. 18, No. 6 ( 2021-6-1), p. e1003661-
    Details
    In: PLOS Medicine, Public Library of Science (PLoS), Vol. 18, No. 6 ( 2021-6-1), p. e1003661-
    Abstract: Obesity, a known risk factor for cardiovascular disease and heart failure (HF), is associated with adverse cardiac remodeling in the general population. Little is known about how nutritional status modifies the relationship between obesity and outcomes. We aimed to investigate the association of obesity and nutritional status with clinical characteristics, echocardiographic changes, and clinical outcomes in the general community. Methods and findings We examined 5,300 consecutive asymptomatic Asian participants who were prospectively recruited in a cardiovascular health screening program (mean age 49.6 ± 11.4 years, 64.8% male) between June 2009 to December 2012. Clinical and echocardiographic characteristics were described in participants, stratified by combined subgroups of obesity and nutritional status. Obesity was indexed by body mass index (BMI) (low, ≤25 kg/m 2 [lean]; high, 〉 25 kg/m 2 [obese]) (WHO-recommended Asian cutoffs). Nutritional status was defined primarily by serum albumin (SA) concentration (low, 〈 45 g/L [malnourished]; high, ≥45 g/L [well-nourished] ), and secondarily by the prognostic nutritional index (PNI) and Global Leadership Initiative on Malnutrition (GLIM) criteria. Cox proportional hazard models were used to examine a 1-year composite outcome of hospitalization for HF or all-cause mortality while adjusting for age, sex, and other clinical confounders. Our community-based cohort consisted of 2,096 (39.0%) lean–well-nourished (low BMI, high SA), 1,369 (25.8%) obese–well-nourished (high BMI, high SA), 1,154 (21.8%) lean–malnourished (low BMI, low SA), and 681 (12.8%) obese–malnourished (high BMI, low SA) individuals. Obese–malnourished participants were on average older (54.5 ± 11.4 years) and more often women (41%), with a higher mean waist circumference (91.7 ± 8.8 cm), the highest percentage of body fat (32%), and the highest prevalence of hypertension (32%), diabetes (12%), and history of cardiovascular disease (11%), compared to all other subgroups (all p 〈 0.001). N-terminal pro B-type natriuretic peptide (NT-proBNP) levels were substantially increased in the malnourished (versus well-nourished) groups, to a similar extent in lean (70.7 ± 177.3 versus 36.8 ± 40.4 pg/mL) and obese (73.1 ± 216.8 versus 33.2 ± 40.8 pg/mL) ( p 〈 0.001 in both) participants. The obese–malnourished (high BMI, low SA) group also had greater left ventricular remodeling (left ventricular mass index, 44.2 ± 1.52 versus 33.8 ± 8.28 gm/m 2 ; relative wall thickness 0.39 ± 0.05 versus 0.38 ± 0.06) and worse diastolic function (TDI-e′ 7.97 ± 2.16 versus 9.87 ± 2.47 cm/s; E/e′ 9.19 ± 3.01 versus 7.36 ± 2.31; left atrial volume index 19.5 ± 7.66 versus 14.9 ± 5.49 mL/m 2 ) compared to the lean–well-nourished (low BMI, high SA) group, as well as all other subgroups ( p 〈 0.001 for all). Over a median 3.6 years (interquartile range 2.5 to 4.8 years) of follow-up, the obese–malnourished group had the highest multivariable-adjusted risk of the composite outcome (hazard ratio [HR] 2.49, 95% CI 1.43 to 4.34, p = 0.001), followed by the lean–malnourished (HR 1.78, 95% CI 1.04 to 3.04, p = 0.034) and obese–well-nourished (HR 1.41, 95% CI 0.77 to 2.58, p = 0.27) groups (with lean–well-nourished group as reference). Results were similar when indexed by other anthropometric indices (waist circumference and body fat) and other measures of nutritional status (PNI and GLIM criteria). Potential selection bias and residual confounding were the main limitations of the study. Conclusions In our cohort study among asymptomatic community-based adults in Taiwan, we found that obese individuals with poor nutritional status have the highest comorbidity burden, the most adverse cardiac remodeling, and the least favorable composite outcome.
    Type of Medium: Online Resource
    ISSN: 1549-1676
    URL: Article
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    DOI: 10.1371/journal.pmed.1003661
    DOI: 10.1371/journal.pmed.1003661.g001
    DOI: 10.1371/journal.pmed.1003661.g002
    DOI: 10.1371/journal.pmed.1003661.t001
    DOI: 10.1371/journal.pmed.1003661.t002
    DOI: 10.1371/journal.pmed.1003661.t003
    DOI: 10.1371/journal.pmed.1003661.t004
    DOI: 10.1371/journal.pmed.1003661.s001
    DOI: 10.1371/journal.pmed.1003661.s002
    DOI: 10.1371/journal.pmed.1003661.s003
    DOI: 10.1371/journal.pmed.1003661.s004
    DOI: 10.1371/journal.pmed.1003661.s005
    DOI: 10.1371/journal.pmed.1003661.s006
    DOI: 10.1371/journal.pmed.1003661.s007
    DOI: 10.1371/journal.pmed.1003661.s008
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2021
    detail.hit.zdb_id: 2164823-2
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