In:
Oral Diseases, Wiley, Vol. 29, No. 3 ( 2023-04), p. 1282-1290
Abstract:
Whether oral lichen planus (OLP) was potentially malignant remains controversial. Here, we examined associations of ZNF582 methylation ( ZNF582 m ) with OLP lesions, dysplastic features and squamous cell carcinoma (OSCC). Materials and Methods This is a case–control study. ZNF582 m was evaluated in both lesion and adjacent normal sites of 42 dysplasia, 90 OSCC and 43 OLP patients, whereas ZNF582 m was evaluated only in one mucosal site of 45 normal controls. High‐risk habits affecting ZNF582 m such as betel nut chewing and cigarette smoking were also compared in those groups. Results OLP lesions showed significantly lower ZNF582 m than those of dysplasia and OSCC. At adjacent normal mucosa, ZNF582 m increased from patients of OLP, dysplasia, to OSCC. In addition, ZNF582 m at adjacent normal sites in OLP patients was comparable to normal mucosa in control group. Dysplasia/OSCC patients with high‐risk habits exhibited significantly higher ZNF582 m than those without high‐risk habits. However, ZNF582 m in OLP patients was not affected by those high‐risk habits. Conclusions OLP is unlikely to be potentially malignant based on ZNF582 m levels. ZNF582 m may also be a potential biomarker for distinguishing OLP from true dysplastic features and OSCC, and for monitoring the malignant transformation of OLP, potentially malignant disorders with dysplastic features and OSCC.
Type of Medium:
Online Resource
ISSN:
1354-523X
,
1601-0825
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2008428-6
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