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Development and external validation of a breast cancer absolute risk prediction model in Chinese population

Han, Yuting ; Lv, Jun ; Yu, Canqing ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Breast Cancer Research Vol. 23, No. 1 ( 2021-12)

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In: Breast Cancer Research, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2021-12)

Abstract: In contrast to developed countries, breast cancer in China is characterized by a rapidly escalating incidence rate in the past two decades, lower survival rate, and vast geographic variation. However, there is no validated risk prediction model in China to aid early detection yet. Methods A large nationwide prospective cohort, China Kadoorie Biobank (CKB), was used to evaluate relative and attributable risks of invasive breast cancer. A total of 300,824 women free of any prior cancer were recruited during 2004–2008 and followed up to Dec 31, 2016. Cox models were used to identify breast cancer risk factors and build a relative risk model. Absolute risks were calculated by incorporating national age- and residence-specific breast cancer incidence and non-breast cancer mortality rates. We used an independent large prospective cohort, Shanghai Women’s Health Study (SWHS), with 73,203 women to externally validate the calibration and discriminating accuracy. Results During a median of 10.2 years of follow-up in the CKB, 2287 cases were observed. The final model included age, residence area, education, BMI, height, family history of overall cancer, parity, and age at menarche. The model was well-calibrated in both the CKB and the SWHS, yielding expected/observed ( E/O ) ratios of 1.01 (95% confidence interval (CI), 0.94–1.09) and 0.94 (95% CI, 0.89–0.99), respectively. After eliminating the effect of age and residence, the model maintained moderate but comparable discriminating accuracy compared with those of some previous externally validated models. The adjusted areas under the receiver operating curve (AUC) were 0.634 (95% CI, 0.608–0.661) and 0.585 (95% CI, 0.564–0.605) in the CKB and the SWHS, respectively. Conclusions Based only on non-laboratory predictors, our model has a good calibration and moderate discriminating capacity. The model may serve as a useful tool to raise individuals’ awareness and aid risk-stratified screening and prevention strategies.

Type of Medium: Online Resource

ISSN: 1465-542X

URL: Article

DOI: 10.1186/s13058-021-01439-2

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2041618-0

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High-efficiency degradation of phthalic acid esters (PAEs) by Pseudarthrobacter defluvii E5: Performance, degradative pathway, and key genes

Chen, Fangyuan ; Chen, Yuchi ; Chen, Chang ; [et al.]

Elsevier BV ; 2021

In: Science of The Total Environment Vol. 794 ( 2021-11), p. 148719-

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In: Science of The Total Environment, Elsevier BV, Vol. 794 ( 2021-11), p. 148719-

Type of Medium: Online Resource

ISSN: 0048-9697

URL: Article

DOI: 10.1016/j.scitotenv.2021.148719

RVK:

AR 10100

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 1498726-0

detail.hit.zdb_id: 121506-1

SSG: 12

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Assessment of site contaminated soil remediation based on an input output life cycle assessment

Chen, Chang ; Zhang, Xuemei ; Chen, Jiaao ; [et al.]

Elsevier BV ; 2020

In: Journal of Cleaner Production Vol. 263 ( 2020-08), p. 121422-

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In: Journal of Cleaner Production, Elsevier BV, Vol. 263 ( 2020-08), p. 121422-

Type of Medium: Online Resource

ISSN: 0959-6526

URL: Article

DOI: 10.1016/j.jclepro.2020.121422

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 1179393-4

detail.hit.zdb_id: 2029338-0

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BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1–MCM2 signaling during pregnancy

Xu, Xiaoling ; Chen, Eric ; Mo, Lihua ; [et al.]

Oxford University Press (OUP) ; 2019

In: Human Molecular Genetics Vol. 28, No. 5 ( 2019-03-01), p. 842-857

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In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 28, No. 5 ( 2019-03-01), p. 842-857

Type of Medium: Online Resource

ISSN: 0964-6906 , 1460-2083

URL: Article

DOI: 10.1093/hmg/ddy398

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2019

detail.hit.zdb_id: 1474816-2

SSG: 12

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The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry

Shao, Changwei ; Bao, Baolong ; Xie, Zhiyuan ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Nature Genetics Vol. 49, No. 1 ( 2017-1), p. 119-124

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 49, No. 1 ( 2017-1), p. 119-124

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.3732

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 1494946-5

SSG: 12

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Effect of Kinesiophobia Mediated Disease Perception on Rehabilitation Exercise Adherence in Patients Undergoing Percutaneous Coronary Intervention

LI, Juanli ; CHEN, Fangyuan ; ZHENG, Xiaopu ; [et al.]

China Science Publishing & Media Ltd. ; 2023

In: Rehabilitation Medicine Vol. 33, No. 3 ( 2023-06-1), p. 216-222

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In: Rehabilitation Medicine, China Science Publishing & Media Ltd., Vol. 33, No. 3 ( 2023-06-1), p. 216-222

Type of Medium: Online Resource

ISSN: 2096-0328

URL: Article

DOI: 10.3724/SP.J.1329.2023.03004

Language: English

Publisher: China Science Publishing & Media Ltd.

Publication Date: 2023

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Exponential Fertilization Regimes Improved Growth and Nutrient Status of Quercus nuttallii Container Seedlings

Ni, Ming ; Gao, Zhenzhou ; Chen, Hong ; [et al.]

MDPI AG ; 2022

In: Agronomy Vol. 12, No. 3 ( 2022-03-10), p. 669-

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In: Agronomy, MDPI AG, Vol. 12, No. 3 ( 2022-03-10), p. 669-

Abstract: Background: The conventional fertilization regime ignores the allometric characteristics of Quercus nuttallii seedlings, challenging them to meet the nutritional needs at each growth stage. This study was conducted to determine the impact of exponential fertilization on the growth and nutrient status of Q. nuttallii container seedlings. Methods: Two fertilization regimes (average/exponential) were performed on Q. nuttallii container seedlings, and varied gradients (0, 300, 500, 700, and 900 mg/seedling) of N supply were set for the two regimes. Result: N application promoted the seedling height, root collar diameter, total biomass, and N/P/K accumulation of Q. nuttallii, and the exponential fertilization obtained better effects in general. An appropriate amount of exponentially N application was beneficial to the growth of root system, whereas excessive dosages inhibited it. Judging from seedlings growth status and nutrient accumulation, 900 mg/seedling under exponential fertilization was adequate for Q. nuttallii seedlings. However, 500 and 700 mg/seedling under exponential fertilization may have advantages in improving seedlings’ stress resistance. Conclusions: Exponential fertilization did not only meet the nutrient requirements and promote the growth of Q. nuttallii seedlings, but also facilitated the root growth to indirectly accelerate the assimilation of N/P/K, therefore improving the afforestation quality.

Type of Medium: Online Resource

ISSN: 2073-4395

URL: Article

DOI: 10.3390/agronomy12030669

Language: English

Publisher: MDPI AG

Publication Date: 2022

detail.hit.zdb_id: 2607043-1

SSG: 23

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Table_4.XLSX

Wu, Qikui ; Chen, Hong ; Zhang, Zihan ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Plant Science Vol. 13 ( 2022-6-2)

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In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2022-6-2)

Abstract: Styrax tonkinensis has great potential as a biofuel feedstock source having industrial oilseeds with excellent fatty acids (FAs) composition and good fuel properties. Photosynthesis in the developing pericarp could affect the carbon distribution in kernel. During kernel development, more carbon sources are allocated to starch rather than lipid, when the pericarp photosynthesis is reduced by fruit shading treatment. After shading the fruits at 50 days after flowering (DAF), samples of shaded fruit (FSK) and controls (CK) were collected at 80 DAF and analyzed using the proteomic method. We identified 3,181 proteins, of which 277 were differentially expressed proteins, all downregulated in the FSK group. There were 56 proteins found involved in carbohydrate metabolism and lipid biosynthesis leading to oil accumulation with their iTRAQ ratios of FSK/CK ranging from 0.7123 to 1.1075. According to the qRT-PCR analyses, the key genes related to FA and triacylglycerol (TAG) biosynthesis were significantly downregulated between 60 and 90 DAF especially at 80 DAF, while the key genes involved in starch biosynthesis and FA desaturase had no significant difference between the two groups at 80 DAF. Fruit shading is a negative treatment for lipid accumulation but not starch accumulation by restraining enzymic protein expression involved in FA and TAG biosynthesis during S. tonkinensis kernel development.

Type of Medium: Online Resource

ISSN: 1664-462X

URL: Article

DOI: 10.3389/fpls.2022.905633

DOI: 10.3389/fpls.2022.905633.s001

DOI: 10.3389/fpls.2022.905633.s002

DOI: 10.3389/fpls.2022.905633.s003

DOI: 10.3389/fpls.2022.905633.s004

DOI: 10.3389/fpls.2022.905633.s005

DOI: 10.3389/fpls.2022.905633.s006

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2687947-5

detail.hit.zdb_id: 2613694-6

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Table_2.XLSX

Chen, Hong ; Wu, Qikui ; Ni, Ming ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Plant Science Vol. 13 ( 2022-6-6)

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In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2022-6-6)

Abstract: As a promising oil species, Styrax tonkinensis has great potential as a biofuel due to an excellent fatty acid composition. However, frequent flooding caused by global warming and the low tolerance of the species to waterlogging largely halted its expansion in waterlogged areas. To explore endogenous hormones and phytohormone-related molecular response mechanism of S. tonkinensis under waterlogging, we determined 1-aminocyclopropane-1-carboxylic acid (ACC) and three phytohormone content (ABA, abscisic acid; SA, salicylic acid; IAA, indole-3-acetic acid) and analyzed the transcriptome of its seedlings under waterlogged condition of 3–5 cm. The sample collecting time was 0, 9, 24, and 72 h, respectively. It was concluded that ACC presented an upward trend, but other plant hormones showed a downward trend from 0 to 72 h under waterlogging stress. A total of 84,601 unigenes were assembled with a total length of 81,389,823 bp through transcriptome analysis. The GO enrichment analysis of total differentially expressed genes (DEGs) revealed that 4,637 DEGs, 8,238 DEGs, and 7,146 DEGs were assigned into three main GO functional categories in 9 vs. 0 h, 24 vs. 0 h, and 72 vs. 0 h, respectively. We also discovered several DEGs involved in phytohormone synthesis pathway and plant hormone signaling pathway. It was concluded that the decreased transcription of PYL resulted in the weak ABA signal transduction pathway. Moreover, decreased SA content caused by the low-expressed PAL might impact the resistance of S. tonkinensis seedlings under waterlogging stress. Our research may provide a scientific basis for the understanding of the endogenous hormone response mechanism of S. tonkinensis to waterlogging and lay a foundation for further exploration of the waterlogging defect resistance genes of S. tonkinensis and improving its resistance to waterlogging stress.

Type of Medium: Online Resource

ISSN: 1664-462X

URL: Article

DOI: 10.3389/fpls.2022.896850

DOI: 10.3389/fpls.2022.896850.s001

DOI: 10.3389/fpls.2022.896850.s002

DOI: 10.3389/fpls.2022.896850.s003

DOI: 10.3389/fpls.2022.896850.s004

DOI: 10.3389/fpls.2022.896850.s005

DOI: 10.3389/fpls.2022.896850.s006

DOI: 10.3389/fpls.2022.896850.s007

DOI: 10.3389/fpls.2022.896850.s008

DOI: 10.3389/fpls.2022.896850.s009

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2687947-5

detail.hit.zdb_id: 2613694-6

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Impact of carotid atherosclerosis on arrhythmia recurrence following atrial fibrillation catheter ablation

Luo, Fangyuan ; Sun, Liping ; Li, Jiaju ; [et al.]

Wiley ; 2023

In: Pacing and Clinical Electrophysiology Vol. 46, No. 4 ( 2023-04), p. 332-340

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In: Pacing and Clinical Electrophysiology, Wiley, Vol. 46, No. 4 ( 2023-04), p. 332-340

Abstract: It remains unclear whether carotid atherosclerosis (CAS) increases the atrial fibrillation (AF) recurrence rate after ablation. The aim was to assess the association between CAS, defined as carotid intima‐media thickness (CIMT) ≥1 mm and or presence of carotid plaques, and AF recurrence rate after ablation. Methods We retrospectively collected patients who underwent carotid ultrasonography and AF ablation at the First Affiliated Hospital of Zhengzhou University. The AF recurrence was defined as documented atrial arrhythmias over 30 s on ECG or 24‐h Holter monitoring after the first three months blanking period. Cox regression models were used to analyze the risk of AF recurrence. Results Overall, 385 patients were analyzed (mean age, 60.58±10.98 years old; female, 41.30%; persistent AF, 47.27%). After a follow‐up of 1 year, 138 (35.84%) patients experienced recurrence, Kaplan–Meier analysis showed that patients with the presence of carotid plaques, CIMT ≥1 mm, and CAS had a higher risk of recurrence compared with the absence (all log‐rank p 〈 .05). In multivariate Cox regression analysis, CAS (HR 2.159, ±95% CI 1.320‐3.532, p = .002), carotid plaque (HR 1.815, ±95%CI 1.160‐2.841, p = .009), and CIMT ≥1 mm (HR 1.696, ±95%CI 1.192‐2.413, p = .003) were independently associated with a higher risk of recurrence. In subgroup analysis, the association of CAS, carotid plaque, and AF recurrence rate was weaker in men than women. Conclusion Carotid atherosclerosis, CIMT ≥1 mm, and carotid plaque were significantly associated with a higher AF recurrence rate after radiofrequency catheter ablation. They were all risk factors for the recurrence of AF.

Type of Medium: Online Resource

ISSN: 0147-8389 , 1540-8159

URL: Issue

URL: Article

DOI: 10.1111/pace.v46.4

DOI: 10.1111/pace.14679

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 2037547-5

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