In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 3 ( 2023-3-31), p. e0282726-
Abstract:
Although some studies have shown that tranexamic acid is beneficial to patients with intracranial haemorrhage, the efficacy and safety of tranexamic acid for intracranial haemorrhage remain controversial. Method The PubMed, EMBASE, and Cochrane Library databases were systematically searched. The review followed PRISMA guidelines. Data were analyzed using the random-effects model. Results Twenty-five randomized controlled trials were included. Tranexamic acid significantly inhibited hematoma growth in intracranial hemorrhage (ICH) and traumatic brain injury (TBI) patients. (ICH: mean difference -1.76, 95%CI -2.78 to -0.79, I 2 = 0%, P 〈 .001; TBI: MD -4.82, 95%CI -8.06 to -1.58, I 2 = 0%, P = .004). For subarachnoid hemorrhage (SAH) patients, it significantly decreased the risk of hydrocephalus (OR 1.23, 95%CI 1.01 to 1.50, I 2 = 0%, P = .04) and rebleeding (OR, 0.52, 95%CI 0.35 to 0.79, I 2 = 56% P = .002). There was no significance in modified Rankin Scale, Glasgow Outcome Scale 3–5, mortality, deep vein thrombosis, pulmonary embolism, or ischemic stroke/transient ischemic. Conclusion Tranexamic acid can significantly reduce the risk of intracranial haemorrhage growth in patients with ICH and TBI. Tranexamic acid can reduce the incidence of complications (hydrocephalus, rebleeding) in patients with SAH, which can indirectly improve the quality of life of patients with intracranial haemorrhage.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0282726
DOI:
10.1371/journal.pone.0282726.g001
DOI:
10.1371/journal.pone.0282726.g002
DOI:
10.1371/journal.pone.0282726.g003
DOI:
10.1371/journal.pone.0282726.t001
DOI:
10.1371/journal.pone.0282726.s001
DOI:
10.1371/journal.pone.0282726.s002
DOI:
10.1371/journal.pone.0282726.s003
DOI:
10.1371/journal.pone.0282726.s004
DOI:
10.1371/journal.pone.0282726.s005
DOI:
10.1371/journal.pone.0282726.r001
DOI:
10.1371/journal.pone.0282726.r002
DOI:
10.1371/journal.pone.0282726.r003
DOI:
10.1371/journal.pone.0282726.r004
DOI:
10.1371/journal.pone.0282726.r005
DOI:
10.1371/journal.pone.0282726.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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