In:
Journal of Digestive Diseases, Wiley, Vol. 16, No. 1 ( 2015-01), p. 22-30
Abstract:
The cornerstone of conventional treatment for inflammatory bowel disease ( IBD ) is glucocorticoid ( GC ). Single nucleotide polymorphisms ( SNPs ) of genes such as multidrug resistance 1 ( MDR1 ) are related to patient's response to GC , and MDR1 polymorphisms are associated with susceptibility to IBD in C aucasians. We aimed to investigate whether the polymorphisms of five genes including MDR1 influence the response to GC in C hinese patients and the relationship between MDR1 and IBD susceptibility. Methods SNPs were selected and genotyped in 156 IBD patients treated with GC and 223 healthy controls. Patients were evaluated and classified as GC‐dependent, GC‐resistant or responsive to GC after treatment. Results The CC genotypes of rs1128503 and rs1045642 in MDR1 gene were more frequent in C rohn's disease ( CD ) patients who were GC ‐dependent than in those responsive to GC (odds ratio [ OR ] 6.583, 95% confidence interval [ CI ] 1.760–24.628, P = 0.019 and OR 3.873, 95% CI 1.578–9.506, P = 0.009, respectively). The G allele of MDR1 rs2032582 was less frequent among CD patients than in controls ( OR 0.668, 95% CI 0.484–0.921, P = 0.014). G allele carriers were also less likely to develop non‐stricturing and non‐penetrating CD ( OR 0.661, 95% CI 0.462–0.946, P = 0.023) and ileocolonic CD ( OR 0.669, 95% CI 0.472–0.948, P = 0.024). Conclusions Polymorphisms of MDR1 are associated with patient's GC response and a predisposition to CD in C hinese population. Further studies are needed to elucidate the role of MDR1 polymorphisms in IBD and that as genetic markers for GC response.
Type of Medium:
Online Resource
ISSN:
1751-2972
,
1751-2980
DOI:
10.1111/cdd.2015.16.issue-1
DOI:
10.1111/1751-2980.12205
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2317117-0
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