In:
Experimental Diabetes Research, Hindawi Limited, Vol. 2011 ( 2011), p. 1-6
Abstract:
Aims . The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether the SLC2A9 gene variations are associated with type 2 DM in Han Chinese. Methods . Three common SNPs of the SLC2A9 , rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan. Results . The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM ( P = .002 ). Per-copy increase in the minor C-allele results in 0.13 mmol/L ( P = .037 ) and 10.03 μmol/L ( P = .016 ) decrease in serum glucose and UA, respectively. Conclusions . The SNP rs1014290 within the SLC2A9 gene is associated with type 2 DM in Han Chinese.
Type of Medium:
Online Resource
ISSN:
1687-5214
,
1687-5303
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2011
detail.hit.zdb_id:
2465179-5
detail.hit.zdb_id:
2711897-6
Bookmarklink